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MDMA v.s. 3,4 Methylene Dioxy MethylMethylphenidate.

MedicinalUser247

MedicinalUser247

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I'm just posting to post about MDMA compared 3,4 Methylene Dioxy MethylMethylphenidate. Which one do you think is more euphoric ? Although 3,4 Methylene Dioxy MethylMethylphenidate would be more euphoric hypothetically. There still haven't been too many comparisons between the two molecules. So, I want to get your opinion on it. So, which one do you think is stronger MDMA or 3,4 Methylene Dioxy MethylMethylphenidate ?
 
"3,4 Methylene Dioxy MethylMethylphenidate." is an ill defined term, where is the "methyl" referring to?

To quote the reddit thread I found.
"The SAR for phenethylamine and phenylethylpiperidinium derivatives are completely different, so you can’t look at MDMA and then extrapolate that to the pharmacology of a methylpheniate with an added benzodioxole ring. Phenylethylamines have the ability to interact with all three monoamine transporters, so the ring substituents are modulating the relative affinity of phenethylamines for DAT, NET and SERT. For phenethylamines, para-oxygenated substituents tend to reduce the DAT affinity relative to SERT affinity, so MDMA is a relatively non-selective DA/SERT/NET releaser due to the benzodioxole ring.

But methylphenidate and analogs interact with the transporters in a completely different manner (they are not substrates) and they generally do not interact with SERT (methylphenidate has 2000-fold lower affinity for SERT relative to DAT). So you are not going to create nonselective DA/NE/5-HT releasers by adding ring substituents to methylphenidate. Adding a benzodioxole ring will likely alter the potency of methylphenidate at DAT, but it won’t make it MDMA-like."

TL;DR: MD-methylphenidate will be at best a norepinephrine-dopamine reuptake inhibitor, MDMA will win every time as a serotonin-norepinephrine-dopamine releaser.
 
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Well I was doing a little more research and I discovered that if there were a 3,4 Methylene Dioxy DexMethylphenidate that it would be even stronger than 3,4 Methylene Dioxy MethylMethylphenidate. I think I should do a little more research before I make a post like this again, but I do think that if there were a 3,4 Methylene Dioxy DexMethylphenidate that it would be similar to MDMA. Anyway, I respect your opinion.
 
3,4-MDO-MPH may or may not work like MDMA. I have heard both ways.

1-(3,4-methylenedioxyphenyl)-1-carbomethoxy-1-(2-piperidinyl)methane.png


It's very difficult to make, though, without a Parr hydrogenation apparatus.

Someone correct me if I'm wrong.

I am afraid it might work like MDPV, though, which is a hard to control straight stimulant.
 
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MedicinalUser247 said:
I think I should do a little more research before I make a post like this again, but I do think that if there were a 3,4 Methylene Dioxy DexMethylphenidate that it would be similar to MDMA.
Click to expand...

What makes you think that? Because there is no evidence to support that it would behave similar to MDMA.

It would behave similar to methylnaphthidate, and act as a triple reuptake inhibitor (not as a releasing agent like MDMA). Adding a methylenedioxy ring to reuptake inhibitors doesn't make them MDMA like, take for instance MDPV and pyrovalerone.
 
Rectify said:
How do you know that without testing it?
Click to expand...

Its based on the structural activity relationship of closely related compounds. A methylenedioxy ring would impart similar qualities as a napthyl ring with respect to methylphenidate analogs. Though they'd differ to a degree with regards to DAT/NET/SERT affinity, they'd both act as reuptake inhibitors. The methylenedioxy variant wouldn't suddenly act as a releasing agent like MDMA.
 
Well I came up with a new drug design. I call it butterfly. I call it butterfly because I added two methlyene dioxys to the molecule. To the left is a phenyl with a methylene dioxy attacted to the left of that in the center is a bridge with a ketone sticking on top. To the right of that is another phenyl and to the right of that is another methylene dioxy. Because of the shape of the molecule I call it Butterly. Whether it works I don't know. I call it butterfly. Beacause I kind of got inspired by looking at a lot of the FLY compounds.
 
Rectify said:
As for 3,4-MDO-N-Methyl-MPH, who knows?

N-methyl-1-(3,4-methylenedioxyphenyl)-1-carbomethoxy-1-(2-piperidinyl)methane.png


Even 1 methyl can make a huge difference.
Click to expand...
You almost got it, but the Methelene Dioxy is on the other side. And get rid of the N on the phenyl. Theres no need for that extra part. If you put a methylene dioxy on both sides it would be close to butterfly.
 
MedicinalUser247 said:
I'm just posting to post about MDMA compared 3,4 Methylene Dioxy MethylMethylphenidate. Which one do you think is more euphoric ? Although 3,4 Methylene Dioxy MethylMethylphenidate would be more euphoric hypothetically. There still haven't been too many comparisons between the two molecules. So, I want to get your opinion on it. So, which one do you think is stronger MDMA or 3,4 Methylene Dioxy MethylMethylphenidate ?
Click to expand...
lol methylmethyl
 
What I think would be interesting is if you have a molecule that has the body of Methylphenidate, but only has a single ketone on top which would make the top of the molecule look like Methylcathinone and would have the Methylene Dioxy to the left of the Phenyl.
 
Common, even (sub)atomic changes can make a difference. Like D instead of H and what not but at some point changes are more “cosmetic” than really functional. Also phenidates seem to not have drastically different effects from changes like methyl to ethyl while some other drugs with a such a change become significantly different. So on this I’m with those who think it’ll be orders of magnitude more similar to ritalin than MDMA.
 
Well... If we didn't have people messing around with the MDMA molecule we wouldn't have molecules such as MMDA.
 
It's funny, I read through Shulgins book and some of what's in there dosn't match to what's on Wikipedia. Anyway, I have a new idea... What do you think about 3,4 Methylene Dioxy Desoxypipradrol ? How do you think that would work ?
 
It's also an NDRI. Same SAR as methylphenidate. Inhibiting the dopamine transporters seems relatively easy, based on the range of compounds that do such a thing. I mean compounds like O-2172 don't even have a nitrogen. Making a releaser seems to have a much stricter rule set.
 
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