MDMA tolerance

[Daytripperz]

I took a small 15mg sample of MDMA 2 days ago to see if it works. I've heard however that tolerance can increase exponentially. Is this true? I wondering if I had 150mg would the roll be less effective to any degree and if so how much? Could I still get a good high or would it be significantly less?

 

[BlueBull]

I took a small 15mg sample of MDMA 2 days ago to see if it works. I've heard however that tolerance can increase exponentially. Is this true? I wondering if I had 150mg would the roll be less effective to any degree and if so how much? Could I still get a good high or would it be significantly less?

If you only took 15mg then no, it won't have any impact. You could've probably rolled the very next day and you would've felt the full effects. It is true that MDMA tolerance builds rapidly and for some people exponentially if you exaggerate but not with such small doses, that's 35mg below threshold dose. How much do you weigh? I ask because I want to see if your 150mg dose is about right for your first time

 

[Daytripperz]

I weigh around 150lbs so I'm doing it at about 1mg/lb.

That's good btw, I was really worried that it would ruin my roll.

 

[Jabberwocky]

No.

Sub threshold doses will not cause tolerance in ANY way. Even if you took 15 mg every day for a week -- 150 would work fine on day 8.

That's like thinking that drinking a half a beer every day for a week would make that 6 pack hit you any less hard. -- Not flaming you -- just Think about it

And exponential is total BS.

"Tolerance studies also support differences in mechanisms of action. In one study, MDMA was consumed at 9:00 AM each day for almost a week (120 milligrams the first day and 160 milligrams each subsequent day) and by the fifth day there were no effects from the drug except for some mydriasis. And even this appeared to be lost on the sixth day. At this point of total tolerance, there was consumed (on day #7, at 9:00 AM) 120 milligrams of MDA and the response to it was substantially normal with proper chronology, teeth clench, and at most only a slight decrease in mental change. A complete holiday from any drug for another 6 days led to the reversal of this tolerance, in that 120 milligrams of MDMA had substantially the full expected effects. The fact that MDMA and MDA are not cross-tolerant strengthens the argument that they act in different ways, and at different sites in the brain. "

- Alexander Shulgin PIHKAL entry #109

 

[Jabberwocky]

MDMA does not build tolerance exponentially -- in any reasonable use of "exponentially"

going from power 1 to power 2 would be going from 100 mg to 10 grams

It actually quickly builds complete tolerance (detailed by shulgin below)

NOTE -- very high doses of MDMA result in large amounts of metabolites that are ACTIVE amphetamines -- there is no data on the tolerance profile of these metabolites. There is likely some, however, the metabolites are likely the cause for the increasingly speedy, cranked-out feelings associated with post tolerance high dose bingeing reported by some users.

Furthermore the tolerance disappears as quickly as it comes


" Tolerance studies also support differences in mechanisms of action. In one study, MDMA was consumed at 9:00 AM each day for almost a week (120 milligrams the first day and 160 milligrams each subsequent day) and by the fifth day there were no effects from the drug except for some mydriasis. And even this appeared to be lost on the sixth day. At this point of total tolerance, there was consumed (on day #7, at 9:00 AM) 120 milligrams of MDA and the response to it was substantially normal with proper chronology, teeth clench, and at most only a slight decrease in mental change. A complete holiday from any drug for another 6 days led to the reversal of this tolerance, in that 120 milligrams of MDMA had substantially the full expected effects. The fact that MDMA and MDA are not cross-tolerant strengthens the argument that they act in different ways, and at different sites in the brain. " - Alexander Shulgin, PIHKAL #109