The most dangerous are MAO-a-inhibitors. They prevent body of breaking up serotonine. Some herbs also have some quantities of different MAO-is, like rhodiola rosea. So niche supplements should be also approached with caution, they might have different minor effects to serotonergic system also.
SSRIs are said to be dangerous, but I have yet to see any proof of that-MDMA is SSRI also, and pretty strong one. In almost any imaginable scenario, SSRIs should decrease the strength of MDMA. My friend told that this global rumour actually originated from some inaccurate news article from Finland-it has been traced all the way back here and it was first time the claim was made.
YOU SHOULD STILL AVOID TRAMADOL, as there is pretty much going on with that one. it is genuine seizure risk. Also kratom should be approached with caution, I don't know what is going on with that, but it has some serotonergic qualities and I have heard it occasionally causing bad reaction in people with other serotonergic drugs. I don't have much experience about kratom, and someone else might be able to tell us more. Methadone is also one opioid that has some interesting qualities as far as I can recall, but I have never heard anyone having issues with their regular dose and MDMA. That is neither my specialty.
Other amphetamines are generally just lackluster combined, but apparently you are not intending to take meth before the session.
You are right on all three imo. St. Johns Wort is another herbal that you should avoid.
SSRI are, at least proven by user reports, that when on em MDMA doesnt work or needs Elephant doses.
So most people on them stop a few days before dropping and still experience diminished effect.
Fluvoxamine is an the exception cause it inhibits enzymes CYP3A4 moderatly and CYP2D6 weak according to wiki.
Both part of cytorome P450 pathway breaking down MDMA. My GF pucked her guts out and overal felt wrong.
Which makes it contraindicated as combo.
Other SSRIs after MDMA will stop it from working as they kick in, depends on how fast they are absorbed.
No need to wait three weeks like for teh 'so called' anti-depressant effects to show. the effects are instant.
Any MDMA after is blocked, useless.
Based that on the early research on neuro-protective effects of SSRIs. That where proposed at that time.
The reason I did this a little while, but that mistake, taking Fluvoxamine was the end.
Was it ever confirmed or debunked that neuro damage and protectetive action of a SSRI?
Now i d say stick to 1x 3 month rule max 1 redose, what fits you best.
Btw a switch, regular Amphetamine would probably mess less with MDMA. Then Meth would.
