MDA Less Damaging then MDMA?

[Dreamatone]

well they share the same precursors james, yes
but i would assume most MDMA isnt made from MDA.
thast not the easiest and most efficient synth.
its possible to go MDA--->MDMA but i am pretty sure thats not how most clandestine MDMA is made.

There is actually an old tek if i remember correctly which goes from safrole ->MDA -> MDMA. Anyway, most MDMA is made safrole -> MDP2P which is readily converted into a number of MDxx substances like MDMA/MDA.

 

[poopstation]

There is actually an old tek if i remember correctly which goes from safrole ->MDA -> MDMA. Anyway, most MDMA is made safrole -> MDP2P which is readily converted into a number of MDxx substances like MDMA/MDA.

yes in pihkal, shulgin methylates mda to mdma however LSDMDMA&AMP is correct, MDA is not the typical clandestine precursor to MDMA. if going from safrole you can get MDA a number of ways depending on the type of reductive amination being performed. i know this isn't a chemistry forum so i'm going to say reference the hive/rhodium for info on this


dat_boi_simon you're still confused. MDA is not "bad", just a little more neurotoxic than MDMA with a little lower ld50 (from what i've read), so it's the opposite of what the original poster had assumed but IMHO it's not enough to worry about. RGB went into excellent detail explaining this and drawing comparisons between MDA/MDMA and also amphetamine/methamphetamine, you just need to re-read what he posted and read it a little slower. MDA = MethyleneDioxyAmphetamine, MDMA = MethyleneDioxyMethAmphetamine so you see the only difference is the "Methyl" group in MDMA. minor changes to a molecule can mean substantial changes in its pharmacology. for example if you strip off the Methyledioxy group you are left with amphetamine and methamphetamine which are the potent dopamine agonists and as with any potent dopamine agonist they are addicting, that MD group on the amphetamine molecule in the 3,4 position is what makes MDA/MDMA so much vastly different from amphetamine/methamphetmaine. As far as this thread is concerned, MDMA is less neurotoxic than MDA because it is more specific serotonin releaser, MDA releases a bit more dopamine than MDMA thus making it more neurotoxic. The neurotoxicity of the MDxx compounds is linked to the dopamine release, the serotinon release is responsible for 5ht receptor downregulation and not neurotoxicity, big difference. So since MDMA more specifically serotonin and to a lesser extent dopamine it could cause more serotonin receptor downregulation which would exhibit signs of moodiness, depression, etc, and is reversible.

 

[LSDMDMA&AMP]

well yes dreamatone i know you take safrole and convert to ketone (MDP2P).