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MAOi + 5-HTP

S

squeesquee

Greenlighter
Joined
Oct 25, 2010
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1
Sup guys, :)

So the other night, after reading a list of MAO inhibitors, i realized i had two MAOIs (catechin and resveratrol) just sitting around, along with some 5-HTP. Since 5-HTP is rapidly processed by MAO, inhibiting MAO would allow for the 5-HTP to persist longer in the blood, allowing more of it to reach the brain. This also can cause serotonin syndrome if you were to take too much 5-HTP after inhibiting MAO. Despite being aware of that, i decided to take some 5-HTP with catechin and resveratrol. Normally when i take 5-HTP, i do not notice any effects.

In all, I took about 150mg of catechin, 320mg of resveratrol, and 200mg of 5-HTP. Within 2-3 hours, i noticed a very mild euphoria, and a slight increase in energy/awareness that seemed to come on very gently and fade away almost imperceptibly. I would have to say the entire experience lasted about 8-10 hours. I honestly cannot tell you if this is due to a placebo effect or my set of expectations. but honestly, this is all i really would have expected.:|

If any of you are familiar with Ayahuasca brew, the activity one experiences is due to the combined effects of a MAOI and DMT. DMT normally has no activity without an MAOI. That being said, I am really wondering about the potency of resveratrol and catechin as MAOIs, and if they could also produce a similar effect?

My question to you all: have any of you done something similar? Are there any better combinations out there, or ways to make this one more effective without causing problems (serotonin syndrome, etc). The idea would be to keep it OTC.%)

in b4 get some real drugs.:p
[btw this is my first post, long time lurker here!]
 
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Sounds like a recipe for extreme nausea to me...thats why I stopped using 5-HTP...the only thing I've gotten out of high doses (without a MAOI) is serotonin syndrome.:|
 
5-HTP unlike L-DOPA doesn't have the same risk of overdose since the body metabolize it with a mechanism that prevents excess of serotonin from reaching the CNS. It will keep serotonin levels high but not enough to cause serotonin syndrome per se.
Combinations with SSRIs and MAO-AIs thigh can easily lead to serotonin syndrome. In fact the idea of taking 5-HTP with MAO-AIs is stupid and pointless under any circumstance since both raise serotonin levels with MAOIs being by far moe dangerous since they can easily cause neurotrasmitter toxicity if the dose is slightly higher (this danger however does not apply to the same extent for every MAOIs).
 
my thought is that you'd be asking for serotonin syndrome with this combo. i've heard if people carelessly combining 5-HTP, SSRIs, and other serotonergic substances with MAOIs with hopes for "MDMA-like effects" and ending up with bad results.

bottom line: don't do it.
 
On a separate note, any opinions about taking Ayahuasca the day after 5-htp. And what if one were to take 5-htp regularly? Do you think one day off is sufficient to metabolize any remaining 5-htp/seritonin to prevent any interactions with the MAOI in the Aya. THanks for your time.
 
I wouldnt take it anytime before a psychedelic, like a week. It just messes with the motions; Id be more apt to explain if I didn't have to get to bed soon for work tomorrow. 5-HTP is something I wouldn't take regularly because it eventually just makes you depressed because your body stops making its own serotonin.

I just take it very sporadically when I need sleep or after a roll for a couple days, then I stop.

Its basically a very mild psychedelic, but even that tiny bit necessitates a respect for it. That means if you take it too much it will throw you for a loop;)
 
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