knockout_mice
Bluelighter
- Joined
- Mar 3, 2012
- Messages
- 62
I am not new to the forums, but this is my first post, so if i make any mistakes, please forgive me.
I found a few interesting articles about the connection between MAO and behaviour.
http://www.ncbi.nlm.nih.gov/pubmed/10389141
http://www.biomedcentral.com/1471-244X/8/28
selegiline: http://www.mindandmuscle.net/articles/chemically-correct-l-deprenyl-part-ii-by-andrew-novick/
I would be really glad if someone could send me the full text of the former article, because I'm really interested in those "differences in [...] behaviour".
Last week, I started using standard doses (5mg/d) of selegiline (l-deprenyl), which is an irreversible MAO-B inhibitor (with a 40d half-life of inhibition/mao-b recovery) and I noticed a lot of things, like overall mood-lift, motivation, creative/artistic idea flow, vivid dreams, but on the other hand a little sleepiness, and "prickness" / sudden bursts of anger. Also, everything seems more "3D". I'm afraid, that the high dopamine concentrations will downregulate my dopamine receptors so selegiline will lose its effects and in the long run I will fall back to my "old" possible-ADHD, unmotivated state. It seems to work just like methylphenidate, but without the anxiety, comedown and peripheral side effects. I haven't tried amphetamine, but excitotoxicity doesn't sound very fun. Any personal experiences on long-term selegiline? Or studies on DAR receptor availability / tolerance after sel. treatment?
I'm also interested in traditional MAOIs. What do you think, how does it affect behaviour / aggressiveness? Are they good for motivation?
knockout_mice
I found a few interesting articles about the connection between MAO and behaviour.
MAO (monoamine oxidase) A and B are key isoenzymes that degrade biogenic and dietary amines. MAO A preferentially oxidizes serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE), whereas MAO B preferentially oxidizes phenylethylamine (PEA). Both forms can oxidize dopamine (DA). However, the substrate specificity overlap and the in vivo function of these two isoenzymes is not clear. Recently, we have shown that MAO A and B knock-out (KO) mice exhibit distinct differences in neurotransmitter metabolism and behavior. MAO A KO mice have elevated brain levels of 5-HT, NE and DA and manifest aggressive behavior similar to men with a deletion of MAO A. In contrast, MAO B KO mice do not exhibit aggression and only levels of PEA are increased. Both MAO A and B KO mice show increased reactivity to stress. Taken together, these results suggest that MAO A and B have distinctly different roles in monoamine metabolism. Further, these mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders.
http://www.ncbi.nlm.nih.gov/pubmed/10389141
Platelet monoamine oxidase (MAO) activity is highly genetically regulated and has repeatedly been associated with temperament [15]. Low platelet MAO-B activity correlates with personality traits such as sensation seeking, impulsivity and monotony avoidance. Platelet MAO-B has also been associated with deviant behavior such as type II alcoholism, which is a risk factor in adult ADHD. MAO-B is considered to be a marker of serotonergic capacity [15] and low activity has previously been associated with ADHD [16]. Two key genes expressing proteins of major importance for serotonergic activity are the genes encoding the serotonin transporter (5-HTT) and the monoamine oxidase A (MAO-A) enzyme. Both of these genes have functional promoter polymorphisms that have been shown to be associated with behavior: the 5-HTT LPR and the MAO-A VNTR [17,18]. A hypothesis which currently gains increasing experimental support is that prenatal serotonin levels are of importance for the development of the central serotonergic system. This hypothesis is supported by molecular genetic [19], pharmacological [20] and brain imaging studies [21].
http://www.biomedcentral.com/1471-244X/8/28
selegiline: http://www.mindandmuscle.net/articles/chemically-correct-l-deprenyl-part-ii-by-andrew-novick/
I would be really glad if someone could send me the full text of the former article, because I'm really interested in those "differences in [...] behaviour".
Last week, I started using standard doses (5mg/d) of selegiline (l-deprenyl), which is an irreversible MAO-B inhibitor (with a 40d half-life of inhibition/mao-b recovery) and I noticed a lot of things, like overall mood-lift, motivation, creative/artistic idea flow, vivid dreams, but on the other hand a little sleepiness, and "prickness" / sudden bursts of anger. Also, everything seems more "3D". I'm afraid, that the high dopamine concentrations will downregulate my dopamine receptors so selegiline will lose its effects and in the long run I will fall back to my "old" possible-ADHD, unmotivated state. It seems to work just like methylphenidate, but without the anxiety, comedown and peripheral side effects. I haven't tried amphetamine, but excitotoxicity doesn't sound very fun. Any personal experiences on long-term selegiline? Or studies on DAR receptor availability / tolerance after sel. treatment?
I'm also interested in traditional MAOIs. What do you think, how does it affect behaviour / aggressiveness? Are they good for motivation?
knockout_mice