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LSD use up all my serotonin?

MrMan737

MrMan737

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Joined
Jan 9, 2009
Messages
432
Location
CALI, SON
Hellooo.


Me and some buddies took LSD 3 nights in a row.

The first night, we were fucked up as hell off two tabs. The third night (last night) we took 4 tabs each and had an experience that was maybe one tenth as profound as the first night.


We then took 2 hits of ecstasy each, after almost all the way down off the mild acid trip...


and none of us rolled at ALL. Is it possible that all that excessive LSD usage used up all our available excess serotonin, muting the effect of the ecstasy?
 
In the short-term LSD and MDMA can have some cross-tolerance issues. If you lay off the drugs for a few days it'll right itself and you can use either (or both) again if you wish to. The longer the gaps between usage the better, of course. Using either (or both) back to back for multiple days is ineffective at best and harmful at worst. You're best off leaving a good gap between dosing either :)
 
^^
True story

Also you can inhibit anything your bombing with 5-htp (my personal favorite legal precursor) which will help produce serotonin as your rolling/tripping which not only makes you trip/roll "harder" but it helps so you dont burn yourself out, now thats what i call a win/win situation.

Plus taking hydroxytryptophan (5-htp) on its own makes you feel amazing. My mom used to take xanax which isssri's(selective serotonin re-uptake inhibitors) which do the same thing in a different way and it convinced her to get off the xanax and take something more natural.

You can purchase it at the vitamin shop or online for roughly 15-25 for 50-100 mg pills guarenteed any drug that affects your 5-ht pathway will be increased in potency and duration after a few days of usage.
 
Xanax isn't an SSRI as far as I know. Even if it was, SSRIs tend to reduce the effects of psyches/MDMA not enhance them. Not convinced that 5-HTP is all that great either but it certainly has it's proponents... and it's potential dangers. I've never felt the need for it myself.
 
im sorry my mistake your correct it was zoloft, im not a fan of synthetic medication so i stray away from it, as for 5-htp its something to fall back on since you will have excess serotonin you wont "burn" out your receptors. If there are plenty of receptors present then it becomes harder to do permanent damage, I recommend it for those who trip/roll frequently, such as myself, I find i dont have trouble thinking or remembering anything, also the "hangover" effect is completely diminished.
 
BongsBeforeBlunts said:
im sorry my mistake your correct it was zoloft, im not a fan of synthetic medication so i stray away from it, as for 5-htp its something to fall back on since you will have excess serotonin you wont "burn" out your receptors. If there are plenty of receptors present then it becomes harder to do permanent damage, I recommend it for those who trip/roll frequently, such as myself, I find i dont have trouble thinking or remembering anything, also the "hangover" effect is completely diminished.
Click to expand...

Theres not much science here man. For starters, LSD and MDMA are synthetic, so you are a fan of synthetic medication. Most 5HT-P is also synthesised too....?

The more serotonin you have in your brain, the quicker you would "burn out your receptors"- as you'r body will gain a tolerance to the effects of the excess serotonin; remove it, and you have a nice E comedown.

Also- LSD doesn't eat up serotonin or relaease it; it displaces it from the receptor and fits the gap so to speak, modulating neurotransmission, and inducing transmission. There is no release of serotonin. MDMA and LSD work largely in totally different ways.
 
well first considering LSD and MDMA are semi synthetic the only reason i take Molly or L is because i know the people making it one from sassafras the other from ergot.

Alot of 5-htp is synthesized but can also be extracted.

It also is true that you can burn it out with excess serotonin that's why you mediate and moderate it with and when you need it.

It is most definitely not for everyone but I found that it works for me, to each their own.

I was taught a bit of what i know but most is just from observation, i don't think i know everything and im glad that theres someone here who can see if im wrong or not and help to correct me, just a process of learning :D
 
MrMan737 said:
Hellooo.


We then took 2 hits of ecstasy each, after almost all the way down off the mild acid trip...


and none of us rolled at ALL. Is it possible that all that excessive LSD usage used up all our available excess serotonin, muting the effect of the ecstasy?
Click to expand...

Did you or anyone you know take any of the ecstasy from that same batch prior to the LSD parade? Are you positive that the pills are legit MDMA to begin with?? If not, that could be your problem.

I am not sure the degree of cross-tolerance with LSD and MDMA, but if they were good rolls and you took two of them you should have felt *something* even if by comparison it felt like a drop in the bucket...
 
I apologize for going off topic a bit, but will taking a large amount of St. Jon's Wort the day of my roll kill it a little bit too?

I know it's a mild SRI.
 
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