RCs Low sensitivity to drugs like mephedrone/methylone

[GumbyClaymation]

Hi.
I have found that with mephedrone and methylone, I need to take about a full gram orally all at once to have anything beyond a mild reaction. This is neither a quality nor a tolerance issue. I know it's not a quality issue, because others enjoy doses at the normal levels from the same batch. It's not a tolerance issues because I use these quite infrequently. I know some people will binge on these, but I'm still on the 15 g of meph that I purchased almost two years ago.

I'm just curious if there are other people who have found this lack of sensitivity. I haven't read such in any trip reports. For those of you with good biological knowledge, I'm wondering if these reactions can give any insight into the peculiarities of my brain chemistry. Does this mean that I have some imbalance in serotonin/dopamine or the related receptors? I was initially suspicious of my GI tract destroying the chems, but I've also insufflated 250mg meph with only marginal effects. Granted, with that much, probably a significant amount goes into GI tract anyway, but I still think it's got to be in the brain or blood brain barrier.
I've also found that I have a lack of sensitivity for many tryptamines and phenylethylamines. It varies by the particular chem, but many of them only requre 2-3 times the normal dose, not too unusual for a "hardhead". A few, such as 2CI, really have very little action in me even at astronomical levels.
I have not found any opiate derivative that produces useful effects.

Thanks for reading. I'd appreciate any comments.

 

[Timland]

Perhaps it isn't as pure as it was claimed to be? Although it is possible as biochemistry is unique for many. Did you find the Mephedrone to be caustic when it drips? Or was it more uncharacteristically "smooth?"

In my brief and thankfully very temporary foray into RC psychostimulants, including those two substances, I found that purity varied greatly even with the same vendors. The suppliers have nothing to lose by cutting a random batch or two to stretch a buck.

If you have a long history of psychostimulant use then sure it's possible your serotonin and dopamine neurotransmitters/receptors have become a bit "burnt out" over the years. Note that I am not an expert on neurology.

 

[sekio]

If you're getting all these chemicals from the same vendor it's entirely possible that they're cut to hell and everyone else is acting like it's effective/more sensitive than you.

 

[GumbyClaymation]

Thanks for the replies. I've been using RCs for the past 10+ years, but always very infrequently. I have a well established record of hard-headedness. It's mostly been trypts and phens. Bought some methylone about 7 years ago, and then about a year ago. Obviously different vendors. Three purchases of meph from two different vendors. For both chems, it was pretty obvious that others were not faking. I would get barely an elevated heartrate/no pupil change from doses others enjoyed. Pretty clear it's something to do with body chemistry. I'm just wondering if anyone else experiences that level of difference in dosages (5, almost 10 times the dose of others), and if any useful conclusions can be drawn, or if it's merely I need to spend more money and have greater risk of side effects.

FYI, caffeine has little effect on me as well. I could drink a 6 pack of Jolt (remember that stuff?), and go to sleep.

Thanks

 

[BIGsherm7272]

Some people just don't respond well to stimulants, such as me. I have never gotten "high" or any euphoria from any stims, even mdma. But other serotonergic drugs will give me euphoria, such as shrooms and lsd. I also have add and this might play a role in it. I don't really have a definitive answer.

 

[mainvein]

well i got to try 10mg of 2CE about amonth ago after 2 days off heroin...at that point my withdrawls were full in swing, unbeknownst to me since i'd never experienced it before, when i dosed on the RC. i didn't feel anything until i started drinkign alcohol. supposedly, you only need to take a very low dose, 5-7mg of an RC (in gneral), to feel its effects. anyway, the 2CE i got was from a well-respected research university. so i'd suggest if you're not feeling anything from your usua ldose and you still want to feel it, dose low and slow (titration?) until you get your desired effects. i always look up potentiators beofre i try a new drug. remember, you can always do more, but you can't undo what you've already done..