Opioids lope during low dose sub taper

[ladianios]

Is there any benefit using lope during a short sub taper if sub doses are kept under one mg? I know bupe has a higher affinity on the brains receptors but would it remove Lope from the rest of the bodies receptors, the reason I ask is when I did my sub taper I always dosed in the morning and always felt slight wd come on at night in the form of tingly skin and not being able to get real comfy and I am wondering if Lope coulda helped

 

[Mr.Scagnattie]

No low doses of lope while on bupe are not going to do anything, besides maybe help with any diarrhea.

 

[ladianios]

I meant high doses of lope while on low dose bupe to help with slight wd come on at bedtime due to dosing bupe in the morning

 

[Azure Cloud]

I do not think it would affect your response to the bupe. A mu receptor is a mu receptor no matter where in the body. Bupe would aways have the higher affinity (I assume). The lope' would probably just enhance receptor saturation, or so I think.

Safest to start with a relatively low dose of the lope' and judge for yourself as you titrate the dose higher.