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Misc LDN for non opiate user

N

nastypoker

Bluelighter
Joined
Jun 5, 2012
Messages
74
Anyone here used Naltrexone as a drug but not for quitting opiates?

Reading about it and this passage sums it up nicely.

A person takes a very small dose, 1-4 mg at night, they sleep though its effects, it blocks the receptors in the same way but only for several hours. the body makes all its endorphins at night while we sleep, as these receptors are blocked they signal the body to produce a lot more as there's no feed back, then the drugs effects pass, those receptors are unregulated and the amount of endorphins in the system is vastly increased for the next 24 hours.

These endorphins are the controllers of the immune system, its being used off label for autoimmune diseases, cancers, parkisons, MS, depression, chronic fatigue etc etc with good results, increases libido/sensitivity, and general life experience is deeper, think runners high yet with no drug like effects/negatives.

So, anyone have any experience with this sort of thing?
 
i dont have an experience with this or any knowledge but i sure would like to know if someone else could shed some light. This is pretty interesting.
 
Well.. I don't think by supressing the ability to produce endorphins for a short period of time would cause a sudden surge in the production of them afterwards. Actually there was a study where runners were given naltrexone and they still experienced the runners high.

I don't think you'd experience anything by doing it. But there's no harm in trying either I guess.
 
Yeah new studies show the runners high actually is caused by the endocannabinoid receptors. Studies show promising for LDN therapy, I don't have any answers for your question though, sorry.
 
Mass08 said:
Yeah new studies show the runners high actually is caused by the endocannabinoid receptors.
Click to expand...
Runner's high is really not understood yet, there are different studies with different findings, it's probably a combination of things.

OP - I know there are some people on this forum with LDN experience, hopefully they will post :)

synthetix said:
Well.. I don't think by supressing the ability to produce endorphins for a short period of time would cause a sudden surge in the production of them afterwards. Actually there was a study where runners were given naltrexone and they still experienced the runners high.

I don't think you'd experience anything by doing it. But there's no harm in trying either I guess.
Click to expand...

The idea is that blocking the opiate receptors causes a compensatory upregulation of endorphins/enkephalins and/or increases the number of opioid receptors, which lasts beyond the effects of the naltrexone itself, so when taken long-term a nightly dose of LDN can theoretically chronically increase the levels of these endogenous opioids. Basically the reverse of what opioid drugs do. This is the principle at least, there haven't been a whole lot of studies on LDN yet. I'm not sure about the idea of it being immediately acting like the OP said, but in theory that could make sense since some people who are not physically dependent will get a come-down, feeling depressed etc, after opioid drugs wear off, so this would be like the reverse of a come-down.
 
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it makes sense in theory and on paper. but i don't think that the endorphin/endogenous opioid system acts in the same way in which dopamine does for example. although actually i guess the reason for a comedown from opiates is because of the influx of endorphins and now you're in a state of not being able to further produce them for a while. but do we produce endorphins constantly and all the time? perhaps the comedown is just generally the shitty feeling of you no longer having that amount in the brain and also due to depleted dopamine - as GABA is inhibited, dopamine increases, and when your GABA receptor is no longer in a state of inhibition it will produce more, blocking dopamine production when you're already in a lowered state of it.
 
It is certainly and interesting topic. Does anyone know of any negative effects one could experience by taking Naltrexone in these low doses? I feel like it is worth taking the risk as addicts get prescribed doses much larger than this.
 
Ive tried LDN for an autoimmune condition. I used Nodict 50mg from India, finely crushed in 100ml H2O, add few drips of lime juice to dissolve the Naltrexone HCl in the solution. I'd go to bed very late at night though, sometimes 1-2am. Ideally you should go to bed between 9-11pm latest. taken straight before you lay down.
When I awoke, I had fleeting memories of having been awake and restless the whole night. Maybe I had slept with my eyes open, I don't know.
I can't say I noticed an improvement but at that point, I'd already had bowel surgery and developed more strictures(thinning), and most of my problems were related to poor diet and starvation, being too fatigued to cook proper food for myself.

I don't know how correct my info is, but I used it for quite a while until I ran out, at which point my pain levels increased and I needed to up my dose:
I used ULDN (Ultra-LowDN diluted another 10-100 fold. ie: 0.0001-0.01mg) starting low, slowly building up as I noticed an effect, and stopping just before the effect starts to reverse. using once daily before opioid use allowed me to use a slightly lower dose and get a stronger effect. it's said to prevent (or at least help) the buildup of tolerance. I think my usual dose was around 0.03mg, i can't recall.
This was discovered by a Doctor treating an old lady who was acutely dependant on high doses of Morphine. sometimes I'd just take the ULDN on its own and feel lesser withdrawals (or usually sublingually if I needed to use the an opioid right away)
It was really useful to me and I keep meaning to get some more. The opioids I take are Fentanyl & Oxycodone

The tablets, packaging, etc was odourous of Cumin, Fenugreek, ...(reminiscent of Garam Masala) with mid notes of Sewage. I gather this is probably not uncommon given the pollution in India and dense population etc.
but I had no doubt they were Naltrexone because of the sleep disturbances I got with LDN, but not ULDN. associated with opiate receptor antagonism

Really interesting stuff. If anyone knows more about the opiate sparing effects, or has any links, it'd be much appreciated.
 
I did try LDN for an auto-immune disease, including Crohn's symptoms. It was in 2005 - 2006, but before the Univ of PA. study.I tried it for two months. I got no relief of symptoms, unfortunately. I ordered specially made 4.5 mg capsules from a compounding pharmacy in NYC. The theory seems to have some validity. I appeared to get no benefit, even in mood, but Auto-immune diseases are highly individual and very challenging to treat. I've gotten good results from Humira; I'm lucky my health insurance covers it.

I haven't done a great deal of reading on the subject, but their does appear to be a relationship between endorphins and the immune system(if only that exogenous opiates have a de-stressing aspect, and chronic high stress affects the immune system negatively) The theory basically says there is not enough endorphins made naturally in the body for ideal immune system health. I do not know if this is actually true, or if the naltrexone blockade method really results in higher levels.

Some people have benefitted from this. I recall seeing a sticky on a Multiple Sclerosis forum board with a poll asking if it helped anyone who tried it. I seem to remember the number was very low, but not zero.

I think Ultra-low dose naltrexone for opiate reduction/cessation shows more promise. Somebody on BL told a story of being in the hospital, and being given a self-adminstered opiate pain pump, and the solution had ketamine mixed in it, and he felt it did result in less opiate use for pain control. So Ketamine is actually being used for that purpose, apparently.
 
Thanks for those replies. I am reading posts on various forums and there seems to be a lot of support for LDN in general although not much information for non medical use.

Does anyone know how I can work out whether it would be safe to take other drugs whilst on LDN? Specifically nBOME's, MDMA, LSD, marijuana, alcohol and DMT?
 
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