I was on 100 mg Thorazine (chlorpromazine) daily for maybe 4-ish weeks last summer. I cannot give the best of evaluations because of the plethora of other drugs I was on, but I have had experience with it other than those 4 weeks as a PRN, but again with other psych drugs in the mix. Also, it was when I was hospitalized, and then in rehab. I actually, think, though Thorazine is one of the better neuroleptics even against the second generation anti-psychotics. While I was on it daily, it made sleep easy, even though I was quickly detoxed off benzos, which was really irresponsible of the psych ward. But, sleep was easy, and my mind was rather "confined". What I mean by this is that it seemed to have a controlling effect which limited my thoughts and feelings to the immediate present, and I didn't seem to care much about anything. It definitely induced apathy, and wasn't like a fun drug, but it did not seem to worsen any of my feelings. If you would have asked me then I would have said I was feeling fine, now I say I felt like shit, but that summer was horrible itself, and so was the god-awful rehab. It made life then a little (or lot?) more bearable, but seemed to keep me "limited" in some way, short-sighted in the mind. I did have the classic Thorazine face, and did even shuffle a bit, drooled while I was asleep, and became very restless if I had to sit very long. My vision acutally became really fucked up, but I was also on Abilify (5 mg?) and Remeron at the time. The staff at the rehab actually said they were getting other patients saying they were concerned about my over-medicated appearance as well as the staff themselves. I would not take it daily now, surely, but if I hit a really deep, rough patch in my life, I would consider going back on it, probably over any other neuroleptic, with the exception of Compazine, which I hold in the same category due to its very close relation. As a PRN at 25 mg, the Thorazine was sedating, but not TOO sedating, and gave some relief from what I can remember. Now I have a script per my request of Compazine 5 mg as a PRN, which I have taken only a few times, but I feel it is good to have a neuroleptic on hand for those emergency times. According to charts 5 mg Compazine = 35 mg Thorazine, which seems about right. For me the 5 mg Compazine is not too much in the way of sedation, and does not feel over-powering, but I have not had a severe episode requiring it, only a few times I have not felt my best and wanted to try it out to know what to do if something worse were to come along. I think 10 mg Compazine would be better if I were off the rails, and 5 mg sufficient for an episode of moderate transient dysphoria or malaise. Other neuroleptics have just not been as good for my needs as Thorazine or Compazine as a PRN. A lot of the second-generations are just too long-acting, or have too mixed a mechanism of action, or are too sedating. Haldol and Reglan are devlish neuroleptics, which cause me severe restlessness and dysphoria. Seroquel is not terrible, but still not nearly as good for my purposes as Compazine or Thorazine. With either of those (Compazine/Thorazine) the dose can be adjusted pretty well to treat my symptoms. A low dose can take the edge of what benzos cannot, a moderate dose can slow me down and settle me with a bit more force, and a high dose, should it ever be needed, could knock me out. Compazine and Thorazine are more heavy on the serotonin blockade, whereas some of the others I had bad experiences with are heavier on the dopamine blockade, and that I just cannot tolerate.
I don't know what other psych drugs you are on, leftwing, but I might suggest dividing your daily dose of Thorazine a bit more equally for consistent relief of symptoms, because it does have a fairly short half-life and duration of action compared to some other neuroleptics.
