Cimetidine has been shown to inhibit the liver microsomal metabolism of the benzodiazepines diazepam and chlordiazepoxide, resulting in an increase in half-life and decrease in the clearance of these two drugs. Patients receiving the combination of diazepam and cimetidine have been noted to be...
pubmed.ncbi.nlm.nih.gov
Hey everybody
So, I posted a link there to a nice Pubmed article that addresses this topic pretty succinctly. The article does mention the classical Benzodiazepines Chlordiazepoxide (Librium) and Diazepam (Valium), which does bring to the fore some questions. These two Benzodiazepines are older and follow a more complex metabolic process, if you will, then a drug like Clonazepam (Klonopin; Rivotril), which is a comparatively simpler metabolic process. Both of the formerly mentioned Benzodiazepines are routinely found in urine specimens up to 3-4 weeks after last usage, so that tells you something.
I have a lot of experience with Cimetidine and have read about it and it seems to be a true wild card in that if has effects on a wide range of different drugs, but to varying degrees of course. I can only wager that Cimetidine (Tagamet) will somehow slow the metabolism of the Clonazepam, but to what extent, I'm unsure, as there is not a lot of hard data on it.