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Tryptamines Ketamine with 5MeO-DMT

S

scabbard

Bluelighter
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Apr 2, 2024
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Hey,

I'm wondering if anyone here has ever tried these together. A 5MeO-DMT facilitator that I know has had good success with using a small bump of ketamine with clients when they're struggling to break through on 5MeO-DMT; I guess it somehow helps to loosen things up a bit.

If anyone has tried that, what has been your experience? And what dose would be necessary (insufflation) for this technique to be effective?
 
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There are several 5-methoxylated tryptamines.. Are you talking about 5-MeO-DMT?
 
Jeez I should have clarified, yes 5MeO DMT. I will update the original post as well, thank you for pointing that out.
 
I could see a small dose of ketamine being used to lessen the "pre flight anxiety", but ketamine itself in small doses to a non tolerant person can be overwhelming..

I have used ketamine before DMT, with that purpose with succes though.. But DMT is a far scarier substance than 5-MeO-DMT, but YMMV
 
I've used very small amounts of ketamine (~10mg) with DPT (60mg) before and they synergize very well (both insuflated). I'm not a fan at all of ketamine on its own, it weirds me out, but I can't deny that it went very well with DPT, kind of like a launch pad for the more powerful dose of the DPT.

I've also used 5-MeO-DMT a good handful of times, but never with ketamine. I think they probably would synergize well, but be cautious and titrate up over a series of trials if possible as it's territory less travelled. I think a small bump like you described could help to get to a 5-MeO-DMT breakthrough, it kind of makes sense to me.

I wanted to say something about 5-MeO-DMT breakthrough, but it really is beyond words.

Please report back if you do try the ketamine + 5-MeO-DMT
 
I'd recommend having a sitter for this one. Both of these drugs can cause immobility and dissociation. Both have caused deaths due to asphyxiation/aspiration/choking/drowning. Both are pretty safe as mono drugs. Can't hurt to have someone around to look after your body's needs so you can relax and focus on the experience.
 
I recently experienced this combo and thought about sharing my experience but it was a bit of a blur. My dose with the K was 100-150mg insuff with a pretty light dose of the 5 meo. It ended up in a cuddle puddle situation and the K seemed to prolong the effects of the 5-meo-dmt. It was rather intense and I can't recommend this combo to someone who is not very experienced with both substances alone.
 
blazR said:
I could see a small dose of ketamine being used to lessen the "pre flight anxiety", but ketamine itself in small doses to a non tolerant person can be overwhelming..

I have used ketamine before DMT, with that purpose with succes though.. But DMT is a far scarier substance than 5-MeO-DMT, but YMMV
Click to expand...
You jest when describing DMT as far scarier than 5-MeO DMT? I've had ketamine & DMT, yet 5-MeO DMT, on its own is the most terrifying psychedelic I've ever had (nobody could ever get me to volunteer to take 5-MeO DMT again)
 
I know I'm different in that way; DMT vs 5-MeO-DMT..

DMT(and mushrooms) have kicked my ass several times, though I have mostly had pleasant experiences.. but 5-MeO-DMT seems to turn off my fear completely, when vaporized at least.. Intranasal 5-MeO-DMT has been quite scary for me as well..
 
You're not the first to say that about the difference between intranasal and vaporized ROAs
 
I was a bit surprised when I read the comment about DMT being far scarier than 5MeO-DMT. I've only ever tried the latter, but I was under the impression that it was far more powerful than regular NN-DMT, though in some respects that might make it easier to just go with it.

Pfafffed said:
I'd recommend having a sitter for this one. Both of these drugs can cause immobility and dissociation. Both have caused deaths due to asphyxiation/aspiration/choking/drowning. Both are pretty safe as mono drugs. Can't hurt to have someone around to look after your body's needs so you can relax and focus on the experience.
Click to expand...
Yes, a sitter would always be my preference. And even with 5MeO-DMT alone (no K), throwing up is obviously a possibility and I wouldn't want to choke on that. The problem for me is that I like to have a session when I'm feeling ok, which is so infrequent that it makes it difficult to plan for it and usually it's fairly impromptu, so recruiting a sitter would almost necessitate having someone on call haha.

Didgital said:
I recently experienced this combo and thought about sharing my experience but it was a bit of a blur. My dose with the K was 100-150mg insuff with a pretty light dose of the 5 meo. It ended up in a cuddle puddle situation and the K seemed to prolong the effects of the 5-meo-dmt. It was rather intense and I can't recommend this combo to someone who is not very experienced with both substances alone.
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Thanks for sharing. Which type of K did you use? R, S, or racemic? I did do Ketamine once with a therapist, and I can't say I enjoyed the experience at all. But I was pretty worked up going into it so of course any medicine you take in that state is likely not going to yield a pleasant experience.
 
To be fair; these 2 substances are not really comparable IMO/IME. (5-MeO-DMT & n,n-DMT)

The duration and ability to warp the mind out of body is though, but that's about it I think..
 
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perpetualdawn said:
I've used very small amounts of ketamine (~10mg) with DPT (60mg) before and they synergize very well (both insuflated). I'm not a fan at all of ketamine on its own, it weirds me out, but I can't deny that it went very well with DPT, kind of like a launch pad for the more powerful dose of the DPT.

I've also used 5-MeO-DMT a good handful of times, but never with ketamine. I think they probably would synergize well, but be cautious and titrate up over a series of trials if possible as it's territory less travelled. I think a small bump like you described could help to get to a 5-MeO-DMT breakthrough, it kind of makes sense to me.

I wanted to say something about 5-MeO-DMT breakthrough, but it really is beyond words.

Please report back if you do try the ketamine + 5-MeO-DMT
Click to expand...
Ketamine & DPT (50mg/50mg IM) gave me one of the most amazing trips I've ever experienced (it's in the trip stories section: The Purple Passion Prose of the Propyl Product). My ability with words pales in comparison to the trip.
 
I have done this quite a few times in the past. I found a low dose of 5-Meo-DMT with a moderate-to-high dose of Ketamine the most pleasant.
Prevents a bit the blackout tendencies of K and gives it a lot more depth. I.e. 150-200mg of K and 5-10mg of 5-Meo snorted, or alternatively snorting all the K and then smoking smaller hits of 5-Meo when the K kicks in.
The other way around, a higher dose of 5-Meo and a low dose of K is also nice. Thats more of a mystical and shattering experience with a bit less anxiety that sometimes comes with 5-Meo.
High doses of both (i.e. 200mg of K and 30mg of 5-Meo snorted) are not really that great. Its a bit like trying to listen to two different songs on full volume at the same time. Waste of material.
I have also done bumps of mixed K+5-Meo at raves in the past but this led to vomiting at times. Not really desirable.
All in all these drugs mix quite well. the not-so-visual nature of 5-Meo adds to the colorless nihilism of K, and the numbing effects of K help with the at times high bodyload of 5-Meo. But it also takes away some of the purifying and uplifting elements of 5-Meo and turns it into a more hedonistic experience.
 
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