Ketamine and Bupropion (Wellbutrin)

[Marloo]

I am currently taking 300mgs of bupropion and was wondering whether I would have a bad reaction to K. DXM is structurally related to ketamine and that is known to have extremely bad reactions with wellbutrin. I have tried searching everywhere and could not any sufficient information at all. Help?

 

[paranoid android]

Ketamine is ok to take with bupropion as far as i know. I took ketamine multiple times while on bupropion and had no reaction good or bad.

The reason bupropion does not mix well with DXM is because bupropion is a very potent inhibitor of the CYP2D6 liver enzyme which is what is needed to metabolize DXM into DXO.