Timothy Leary
Bluelighter
- Joined
- Dec 5, 2009
- Messages
- 61
ok, people are commenting on JWH-018's nasty looking napthalene group, I wonder how toxic it really is?
However this has not been mentioned in other threads. Propranolol.
It is a betablocker and some people take doses up to 100 mg a day! the worst part is not only does it have an oxygen DIRECTLY ON THE NAPTHALENE, if anyone doesn't know why aromatic compounds are carcinogenic it is because the body finds it hard to get rid of them except through epoxidation. they turn into benzene oxide compounds which are very uncomfortable breaking that aromatic ring and very reactive, so they like to react with your DNA, something that is not exactly healthy. Napthalene is not as bad as benzene. But tolouene (methylbenzene) is comparatively vary safe next to other non-substituted aromatics, this is because the body then gets the chance to oxidize it to benzyl alcohol (not phenol!) and then to benzaldehyde and finaly to benzoic acid, a much less toxic process.
The thing is that Propranolol has an oxygen on the napthalene directly, much worse than JWH which is already an alpha-ketone derivative, it is halfway through its metabolism to naphthoic acid!
For the TL;DR crowd- JWH has a toxic component, but it doesnt look half as bad as a normal betablocker which has a higher dosage.
What do you guys think?
However this has not been mentioned in other threads. Propranolol.
It is a betablocker and some people take doses up to 100 mg a day! the worst part is not only does it have an oxygen DIRECTLY ON THE NAPTHALENE, if anyone doesn't know why aromatic compounds are carcinogenic it is because the body finds it hard to get rid of them except through epoxidation. they turn into benzene oxide compounds which are very uncomfortable breaking that aromatic ring and very reactive, so they like to react with your DNA, something that is not exactly healthy. Napthalene is not as bad as benzene. But tolouene (methylbenzene) is comparatively vary safe next to other non-substituted aromatics, this is because the body then gets the chance to oxidize it to benzyl alcohol (not phenol!) and then to benzaldehyde and finaly to benzoic acid, a much less toxic process.
The thing is that Propranolol has an oxygen on the napthalene directly, much worse than JWH which is already an alpha-ketone derivative, it is halfway through its metabolism to naphthoic acid!
For the TL;DR crowd- JWH has a toxic component, but it doesnt look half as bad as a normal betablocker which has a higher dosage.
What do you guys think?
