Droppersneck
Bluelighter
And will it have a synergistic effect if done in conjunction with opana? I have searched methadone threads but cant find anything on these questions. Any help would be greatly appreciated!
Is there anything beneficial to snorting methadone?
- Thread starter Droppersneck
- Start date
Dont snort methadone. It is metabolized in your gut. It will not metabolize if you snort it, it is a total waste. Also, depending on the size of the methadone dose, it may prevent the opana from having any effect. Take them separately .
Droppersneck
Bluelighter
Thanks I will take it sublingualy. I have 10mgs and my tolerance is 60- 80 mgs of opana. I only have a 20 opana should I still take it separatly?
DelRi0
Bluelighter
Yes man, methadone can and most likely will prevent the Opana from having any effect, especially with your respectable tolerance. It would be best to take them separately. I would vote the Opana first
Droppersneck
Bluelighter
Thanks delrio
DelRi0
Bluelighter
Anytime bud. 
Violenza666
Bluelighter
It burns like a bitch!
Methadones blockade effect is around 80mgs, and I think it is with continued use. If you haven't been taking methadone regularly, I would say that you could combine the two. I wouldn't recommend it though. Safe the methadone for doing it on its own, or to hold off withdrawals.
Violenza666
Bluelighter
I would. I use Opana daily and if I use dones I don't use Opana because it doesn't feel the same. My Opana tolerance is a little bit higher than yours but even when I was doing 60-80mg in one sitting I didn't use dones at the same time... when I did do both I found the Opana to be pointless at that time. I hope this helps!
SeekerOfEuphoria
Bluelighter
This true? Jesus I've snorted methadone quite a few times and always get just as high as when I swallow it. Course it could be dripping down but I wouldn't think whatever percentage of the original dose drip would affect me.
That is not true. It has a very high oral bioavaliability (around 80% ) but it is not metabolised in the gut. It is metabolised by the cytrochrone P450 system in the liver.
I don't kniw what the nasal bioavailability is.. it is dangerous to administer it IV, not just because pills in general (or syrup!) are dangerous to shoot, but because it has been known to cause cardiac arrest.
It's pharmacokinetics are quite complicated.. related reading and wikipedia.
Well, then. Guess I need to read up on it . I was on methadone for years, and know that, when taken orally, it takes a long time to take effect. I was told this was due to the fact that, at least with the form we were taking (biscuits dissolved in water) that the done wasn't metabolized until after it passed through your stomach . Also, it was common knowledge that injecting the form we had was useless, and I tried that and it was, indeed, useless . I know in the UK there are injectable versions, I have no idea how many different forms methadone has . *reads wiki*
Yikes @ talc being in the "Diskets" . Well, guess you learn something new every day .
Yikes @ talc being in the "Diskets" . Well, guess you learn something new every day .
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Wow, a LOT of misinformation in this thread. As a long-time methadone user, as well as it's biggest fan 
I shall set some things straight:
1. To start, Effie is right, it is not metabolized in the gut, and even if it was, it has no active metabolite, ergo, any MOA will work, since methadone itself is active. But that doesn't mean snorting is necessarily a good idea, but you can. I mean seriously WTF do people get this nonsense???
2. The oral BA is usually high, but it can vary wildly, from 40-90%. However, for most people it is in the higher end of that range, and though there is no solid figure for the "mean BA", I can say based on the figures I do have, and common knowledge that it probably averages over 70%. That, combined with an amazing half-life make oral methadone the way to go.
3. Nasal BA is more or less identical to oral, except that it averages just a little bit lower than oral(like 70% versus 65%, or something along those lines). Also, the minimum BA is higher with nasal, but the max BA appears significantly lower as well, as I have never seen a study indicating an 80-90% BA for nasal. Basically, that means that nasal will never yield a BA of less than 50%(which methadone can in some situations) but you will never get 90% out of it, either. Of course, that is more theory than anything, as most people don't snort methadone, so it could just be that there is not enough data.
4. Methadone only blocks in very high doses, and even then, it does a shitty job of blocking powerful opies like opana. You we're not very clear in your post, but if you really only had 10mg of methadone, then you would be lucky to feel it, let alone have it blocked. Honestly, just slightly reduce the dose of each, and it would be fine. As an example, I used to love taking my Methadone dose when I woke up, and later on injecting OC for a synergistic rush.
Finally, DO NO TAKE IT SUB-LINGUAL! MD has a poor metabolism that way. You should honestly just take it orally, but if you we're intent on snorting, that's OK. As I said earlier, the BA will be very similar, but snorting won't last nearly as long, and it isn't any more intense. The only real difference is that nasal starts working a bit faster, but wears out faster and in my opinion never really peaks out as good.
Edit: Let me just say that regular posters know I'm needle happy, but injecting methadone is just fucking pointless! So if I am saying that then it oughta tell ya something...
I shall set some things straight:1. To start, Effie is right, it is not metabolized in the gut, and even if it was, it has no active metabolite, ergo, any MOA will work, since methadone itself is active. But that doesn't mean snorting is necessarily a good idea, but you can. I mean seriously WTF do people get this nonsense???
2. The oral BA is usually high, but it can vary wildly, from 40-90%. However, for most people it is in the higher end of that range, and though there is no solid figure for the "mean BA", I can say based on the figures I do have, and common knowledge that it probably averages over 70%. That, combined with an amazing half-life make oral methadone the way to go.
3. Nasal BA is more or less identical to oral, except that it averages just a little bit lower than oral(like 70% versus 65%, or something along those lines). Also, the minimum BA is higher with nasal, but the max BA appears significantly lower as well, as I have never seen a study indicating an 80-90% BA for nasal. Basically, that means that nasal will never yield a BA of less than 50%(which methadone can in some situations) but you will never get 90% out of it, either. Of course, that is more theory than anything, as most people don't snort methadone, so it could just be that there is not enough data.
4. Methadone only blocks in very high doses, and even then, it does a shitty job of blocking powerful opies like opana. You we're not very clear in your post, but if you really only had 10mg of methadone, then you would be lucky to feel it, let alone have it blocked. Honestly, just slightly reduce the dose of each, and it would be fine. As an example, I used to love taking my Methadone dose when I woke up, and later on injecting OC for a synergistic rush.
Finally, DO NO TAKE IT SUB-LINGUAL! MD has a poor metabolism that way. You should honestly just take it orally, but if you we're intent on snorting, that's OK. As I said earlier, the BA will be very similar, but snorting won't last nearly as long, and it isn't any more intense. The only real difference is that nasal starts working a bit faster, but wears out faster and in my opinion never really peaks out as good.
Edit: Let me just say that regular posters know I'm needle happy, but injecting methadone is just fucking pointless! So if I am saying that then it oughta tell ya something...
Miss Kirsty
Bluelighter
lorne667 is correct...I am also on methadone daily and im needle happy too but i dont even think about injecting mine...( its also watered down!)....
NeighborhoodThreat
Bluelight Crew
Long story short, don't snort your methadone, and don't waste your Opana.
Mixing the two would at best be a waste of drugs and at worst be a very dangerous overdose situation.
Mixing the two would at best be a waste of drugs and at worst be a very dangerous overdose situation.