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  • BDD Moderators: Keif’ Richards | negrogesic

Is there a way to kick Naltrexone out of your system?

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penguinpodex

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May 1, 2014
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I've been looking all over the place, but I can't find any useful information. Does anyone know if there's a drug that can override the Naltrexone? Other than large amounts of dope? My parents mix Naltrexone into my food, so I can't cheek the medication anymore. Any advice will be greatly appreciated.
 
Get food stamps buy your own food problem solved

At least that's what I just did now I have a bunch of food for no reason
 
Damn. I kind of figured it's just a time thing, but I was hoping someone knew another way. Thanks guys.
 
this is not a reply I just don't know yet how to post a question.
I took one 50mg naltrexone. I have never taken it before. How long would it take before it would no longer block any opiates. i.e. heroine?
 
I am prescribed this drug, my Dr has said 24hours. So, if you skip one daily dose, you should be able to get high again. But for gods sake please be careful.. Naltrexone has been shown in newer studies to actually repair the receptor sights while its blocking them and fairly quickly I might add. It will make OD very easy, and it should not be toyed with
 
There are better drugs out there than opiates btw ... they don't care about whether you have naltrexone in your system or not, don't induce life-damaging addiction and don't come with risk of respiratory depression (okay, depending on what drug class you choose, you'll trade that with other risks, but well.. in my eyes opioids are really unique amongst all the drugs currently available.. and I've done them too, so I know what I'm speaking about)

If you pick the right one, it might even make you forget these cravings ;)

Edit: No, seriously, do you feel a difference from taking the naltrexone? Do you feel it at all (tendency to depression, anxiety, cravings for opiates etc.. or the opposite)? Many say if you don't have tolerance, you won't feel it. But well.. I've had absolute hell on earth from intranasal tilidine/naloxone - with no tolerance and thought the naloxone was only active when IV'd - but it still should have just cancelled out the tilidine.. but it was full-on withdrawal. Without being addicted!
 
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I feel a difference when I'm on my Naltrexone, absolutely. I simply don't crave opiates or alcohol. Both of which I have issues with.

Naloxone is the medication Narcan, its given in the emergency field and it basically kicks the opiates off the receptors they've claimed in the brain. My protocol is to administer .8ml sub Q, then attempt my IV starts so I can give much more IV and try to reverse this PTs respiratory failure.

They do however make Narcan in a nasal administration device, and the RCMP in BC will be carrying this soon. They've also been giving it out at various harm reduction centers in Vancouver and Kamloops from what I understand.

Narcan will kick any and all proteins that have bound themselves to the (i forget which receptors exactly) and take that spot. In this sense its quite a powerful medication, although its very very hard to do any damage to a person with. Which is why there is a HUGE push to give it to almost anyone who is fairly competent.
 
Yeah, of course it's a great advance in harm reduction to have Narcan available for opioid overdoses, and a nasal spray would be even better!

The thing is just that these substances (naltrexone as well as naloxone) are not just potent opioid (mu, delta, kappa) blockers / antagonists but in fact reverse agonists. This would explain why, once adjusted to them, they can alleviate cravings for you. But it also means they cause a precipitated withdrawal that is far worse than plain antagonism, or discontinuation of the opioid, would do.

So we should have a neutral, plain (but very potent) antagonist. Or even a equally potent partial agonist with such low intrinsic activity that it would block all the opioid receptors, kick the overdose off them, and very slightly activate them by itself to a safe degree that doesn't lead to respiratory depression but alleviates the worst part of withdrawal symptoms.. somewhat like buprenorphine 2.0. ;)

Also some people seem to have a genetic variant (?) leading to changes in endorphin transmission or somewhat. This has been associated with various mental disorders, including addiction, but mostly the depressive / overly sensitive etc. direction. For those, taking an opioid inverse agonist even when they never did any true opioid before, can be a terrifying experience.. like it was for me.. this is just a theory, but in my eyes a plausible one as the endorphin part is backed by study evidence.
 
Agreed totally, the trouble with medicine is staring us in the face..... the medical community rarely sets out to solve a specific problem then solves it.
Rather, they stumble onto amazing cures and fixes by accident while looking elsewhere.

Bup 2.0 <--- million dollar idea my man, lol.... if it was that easy for us to kick OPi's each time would you ever stay clean? I probably wouldn't lol

And as far as the genetic variant types of people, thats just a shitty roll of the dice. medications unfortunately will always be developed for the masses.... some folks just get a shitty portion of a gene or DNA strand.... can't fix or help that, and although I didn't know about that little tidbit of info you just shared, I can't let that affect my practice. As far as Narcan goes, if it looks like a duck, walks like a duck and has respiratory failure like a duck. Narcan the SOB. And I am so so sorry if you had too much Zoplicone and now your in precipitated withdrawals.... FML thanks to you that'll be in the back of my head now lol
 
when you took said medication, how long had you been off all opiates? and how long for alcohol?
 
Osoyboy said:
Bup 2.0 <--- million dollar idea my man, lol.... if it was that easy for us to kick OPi's each time would you ever stay clean? I probably wouldn't lol
Click to expand...

I know about the thinking of many drug counselors and doctors that a hefty cold turkey withdrawal is necessary to scare people off the drug.. this might have some truth for some, yes.
But not all people are the same. There is evidence that it's actually the intensity of the withdrawal that induces a negative learning and leads to worse relapses... fear never makes a good advisor.

I've gone through various RC opioids and eventually diamorphine (the worst of all I've tried when it comes to effects : price ratio). No needles involved, but I was physically dependent. I got around w/d with pharmacological knowledge at least twice, and I'm done with opioids now. Actually I hate them. But I might be one of these exceptions proving the rule, I don't know really. And while I really don't want to do so, if I were in severe pain or something, I could take a regular dose of an opioid without relapsing - tried.
 
I'm beginning to hate them. I've been in the off/on cycle for 3 years ish now. We have our first baby due in 3 months so it's time for some real self control and effort I'm about to start a 5 day detox in about 8 hours... thank god for a good relationship with an understanding Dr.

She's really understanding and amazing, just gave me everything I needed/asked for as long as I promised not to buy anymore off the street and just to come to her, she said that basically, If i've done my homework and can explain why I want it and for how long that we'll be good to go.... It's difficult though because where I live our General Practitioners (family Dr's) rotate through the emergency dept. in our local hospital SO I see her on a professional level as well.

Haven't had any issues yet, but 'm knocking on wood
 
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