Kratom Is Robaxin safe with kratom?

[Juicewrldfan]

Is it safe to mix these? I have read conflicting information.

 

[Azed]

Current research lacks information on Robaxin's (methocarbamol) binding profile. What we do know is that it is demethylated by the liver.
Kratom (mitragynine) targets three receptor sites MOR (mu opioid receptor), DOR (delta opioid receptor), and KOR (kappa opioid receptor). It should also be noted that Kratom is known to interact with dopamine and serotonin.

Both Kratom and Robaxin are CNS depressants and both substances are metabolized primarily through the liver.

Now here's my two cents...
Simply, I don't believe there is a significant risk of death or harm. I do have some concerns regarding the conflicting enzyme activity resulting in possible over-intoxication or harm. While we lack information to make a definitive call on whether or not these two substances interact at the same receptors or not. What is known is that both substances will potentiate one another and synergize (1+1=4). I think that this combination is not inherently dangerous. If you do try this combination I would start with lower doses of both substances than what you are accustomed to and slowly work your way up to where you are comfortable. As always, you can always take more, but never less.

If you do take these substances together please report back so that the community can learn more about how they interact.


Stay safe and best wishes!
Azed

 

[AngelsandFairiesarereal]

I’ve taken both together before & nothing noteworthy that I can remember happened

 

[Azed]

I’ve taken both together before & nothing noteworthy that I can remember happened

How much of each did you take?

 

[AngelsandFairiesarereal]

How much of each did you take?

Not much actually now that I’m thinking about it …. because I never heard of anyone mixing them so I was cautious & only took a little kratom & 1 or 2 robaxin

 

[AngelsandFairiesarereal]

Not much actually now that I’m thinking about it …. because I never heard of anyone mixing them so I was cautious & only took a little kratom & 1 or 2 robaxin

Like 6 or 7 capsules of kratom & the 1 or 2 robaxins were Robaxin 750s

 

[Azed]

Like 6 or 7 capsules of kratom & the 1 or 2 robaxins were Robaxin 750s

Would you describe what you felt as a high? Was it comfortable or uncomfortable? Are they better when taken individually?

 

[AngelsandFairiesarereal]

Would you describe what you felt as a high? Was it comfortable or uncomfortable? Are they better when taken individually?

Yea I felt a little high, I also took a half a clonazepam with it (but I should note that I was doing it to try to help with tramadol withdrawals)
So I still felt a little crappy (like my stomach) … but I’m not sure if it was from the tramadol withdrawal. My bad I probably should have mentioned all that in my original post

 

[AngelsandFairiesarereal]

Yea they’re probably better taken individually though the kratom & Robaxin

 

[Juicewrldfan]

Yeah. Thanks everyone. I wasn’t sure because there were anecdotal reports of seizures but idk how that combination would cause seizures yet I don’t know much so….