Harm Reduction Is it safe to combine N-Acetyl Cysteine with Kratom and/or alcohol?

[Mycophile]

My psychiatrist wants me to take N-Acetyl Cysteine twice a day to treat my social anxiety. I usually don't take Kratom every day, but right now I've gotten myself dependent on it again, so somedays I take an extract (I know I should stick to plain leaf) and some I take plain leaf. If I can avoid taking it altogether I do, and I plan on breaking my dependency as soon as possible and stopping. I also drink sometimes, and sometimes quite heavily. I don't usually even drink once a week, but I do when the mood strikes.

So, is N-Acetyl Cysteine dangerous and does it have any negative effects when mixed with Kratom or alcohol? I really hope not.

 

[Mycophile]

Anyone have an answer here, and/or any words about how it feels to take this supplement in general? Cause my doctor wants me to start taking it. I read something that said it interferes with a Kratom buzz. Is that true? If so I'd just avoid it when I want to take Kratom. I also heard that it helps people with addiction and makes them not want certain drugs as much, which wouldn't be too bad. But generally I just want to know if this is a supplement with lots of side effects or contraindications.

 

[HealingEnergy14]

I'm pretty sure you should be okay taking them together. Personally I've mostly used NAC to get my focus, motivation and anxiety back after GHB/amphetamine abuse. But i've also used it while on Opioids (perhaps also kratom, can't remember) later on to prevent sickness.

 

[Quasimoto]

NAC blocks the euphoria of kratom, and when taken chronically together it actually caused me some significant issues like anxiety and dysphoria.

NAC combined with alcohol can purportedly be hepatoxic, however NAC has also been purported to protect the liver against alcohol hepatoxicity via glutathione production if taken several hours before the alcohol.... I'm not sure which is true...

NAC is an interesting compound that I've found many uses for, but anxiety is not one of them. It acts as a mood stabilizer but I have no idea why a shrink would recommend it for anxiety. If anything, it exacerbated anxiety for me.

 

[Mycophile]

NAC blocks the euphoria of kratom, and when taken chronically together it actually caused me some significant issues like anxiety and dysphoria.

NAC combined with alcohol can purportedly be hepatoxic, however NAC has also been purported to protect the liver against alcohol hepatoxicity via glutathione production if taken several hours before the alcohol.... I'm not sure which is true...

NAC is an interesting compound that I've found many uses for, but anxiety is not one of them. It acts as a mood stabilizer but I have no idea why a shrink would recommend it for anxiety. If anything, it exacerbated anxiety for me.

Well I won't mix it with those. I can only assume that my psychiatrist knows something you might not know about it, but then again, everyone reacts differently. I really hope it doesn't cause me anxiety or I'll just stop taking it.

Let me ask you though, did it exacerbate social anxiety for you, generalized anxiety, or both? Cause he's recommending it for social anxiety. Also, I take prozac and Klonopin, so it might be some kind of synergy between these drugs.

Also, I've now been told that NAC has to build up in the system over time, and I don't love the idea that if I were taking it I'd NEVER be able to take Kratom unless I stopped.

Do you know how long it takes NAC to leave your system if you've been taking it for a while? Like, just for the sake of argument, if you took it twice a day for a month and then stopped, how long would it be before you could take Kratom and enjoy it again?

Edit: I just found this on Wikipedia, and I should note that my social anxiety is OCD in nature and not typical social anxiety: "Tentative evidence exists for N-acetylcysteine also in the treatment of Alzheimer's disease, autism, obsessive-compulsive disorder.Preliminary evidence showed efficacy in anxiety disorder,"