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is it okay to take alot of 5htp everyday?

cucarot

cucarot

Bluelighter
Joined
Jul 20, 2006
Messages
1,101
i haven't been rolling for 2 weeks now and i've been taking 50mg 5htp everyday.i'm wondering if i will get addicted to it if i take more than 50 mg everyday ?thanks.
 
No, people take it over a reasonably long time as a mood enhancer. I took 50mg Thrice daily for several months.
 
not addiction. but then you never REALLY know. assuem your body finds those serotonin building blocks in abundance... it may just become less and less efficient at using them effectively... kind alike gettign sloppy... then, when you reduce it and thus have fewer serotonin precursors going round your system, how high will your serotonin levels likely be?

Similar problem with melatonin as a sleep aid... though here it's the actual hormone that's administered... melatonin has been reported to cause insomnia in the long term if you stop using it as the body stops its own melatonin production (for some people).

the other risk with using 5-htp all too frequently could be that the body gets oversaturated with 5-htp and can't convert it all... what happens with the rest?
 
I would die if I took that shit everyday. I used to pre/post load with it and I would get horrible comedowns and headaches. I tried not taking it for one session (keep in mind mine are very spaced out) and had absolutely NO problems on the comedown. I plan on doing it again (or not doing it again) this time to see what happens.

Apparently it just doesn't like me.
 
i could tell the different in the first 3 weeks ( sleep better, calmmer ,relax.. ) then after that i don't feel any different .should i take more than 50 mg to make it more effective? thanks.
 
I gave up taking it regularly because i didn't feel it was helping me much.

If you are using it because you use MDMA, i think it probably isn't very worthwhile using it for longer than a week after mdma use, max. I only use it for 3 days.

IIRC people who use it over the longer term will sometimes take breaks from using it.

You aren't going to do yourself any harm, so try different regimes and see what works for you.
 
I'm not a doctor, but I'd be very surprised if there was a problem in taking 50mg of 5-HTP daily. If I remember right, it's marketed as something you can take daily, and in higher doses than 50mg. (I've seen recommended doses of 50-100, 100-200, even up to 400mg daily. 50mg definitely seems like a low dose. I still wouldn't recommend taking more than 150-200 without medical advice though).
 
Ximot said:
/\ reversible?
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Yeah, it's reversible. However, I don't know if downregulation of serotonin receptors has been shown in humans as a result of taking 5-HTP.
 
^I read it here on BL; let me see if I can dig up the post...

Edit- It is mentioned here, but this isn't what I was looking for...
 
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Ximot said:
not addiction. but then you never REALLY know. assuem your body finds those serotonin building blocks in abundance... it may just become less and less efficient at using them effectively... kind alike gettign sloppy... then, when you reduce it and thus have fewer serotonin precursors going round your system, how high will your serotonin levels likely be?

Similar problem with melatonin as a sleep aid... though here it's the actual hormone that's administered... melatonin has been reported to cause insomnia in the long term if you stop using it as the body stops its own melatonin production (for some people).

the other risk with using 5-htp all too frequently could be that the body gets oversaturated with 5-htp and can't convert it all... what happens with the rest?
Click to expand...

This is simply wrong. Your body doesn't become less efficient at using 5-HTP at all. Higher serotonin levels cause your brain's serotonin receptors to downregulate -- a reversible process. Your body DOES compensate to high serotonin levels -- by downregulating the receptors. This is the mechanism responsible for the withdrawl symptoms from SSRIs.

However 5-HTP (by itself) does not increse brain serotonin levels to anywhere *near* what SSRIs do; I'm not aware of any reported cases of 5-HTP withdrawal.

AFAIK melatonin production does not decrease... the melatonin receptor is a G-coupled protein and downregulated just like any other receptor.
 
Lev said:
Too much 5-htp is bad for your heart (although 50mg a day should be ok), especially if it converts to serotonin some place out side the brain... Do a search :)

Also I reckon you'd get very funky dreams after a couple of weeks..
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Most of this is based on rubbish about green bananas and suchlike. You're right -- raised blood serotonin levels are bad for your heart valves ( as demonstrated by the phen-fen combo).

You might want to check out:
http://www.ncbi.nlm.nih.gov/entrez/..._uids=15733932&query_hl=1&itool=pubmed_docsum
Life Sci. 2005 Mar 25;76(19):2171-83.
Links
Serotonergic disturbances in autistic disorder: L-5-hydroxytryptophan administration to autistic youngsters increases the blood concentrations of serotonin in patients but not in controls.
Croonenberghs J, Verkerk R, Scharpe S, Deboutte D, Maes M.

The University Center of Child and Adolescent Psychiatry, A.Z.M., University of Antwerp, Wilrijk, Belgium. [email protected]

Some studies have suggested that disorders in the peripheral and central metabolism of serotonin (5-HT) may play a role in the pathophysiology of autistic disorder. This study examines the whole blood concentrations of 5-HT and 5-hydroxy-indoleacetic acid (5-HIAA) in baseline conditions and during a challenge with L-5-OH-tryptophane (5-HTP; 4 mg/kg in non enteric-coated tablets), the precursor of 5-HT, in a study group of 18 male, post-pubertal, Caucasian autistic patients (age 13-19 y.; I.Q.>55) and 20 matched healthy volunteers. In baseline conditions, no significant differences in 5-HT or 5-HIAA levels could be found between autistic youngsters and normal controls. 5-HTP administration significantly increased the levels of 5-HT in autistic youngsters but not in normal controls. Following 5-HTP challenge the 5-HT levels were significantly higher in autistic patients than in healthy volunteers. After challenge with 5-HTP, no significant differences were found in the concentrations of 5-HIAA or the test substance between autistic youngsters and normal controls. Differences in the peripheral metabolism of 5-HT which may not be observed in baseline conditions but which became clear after loading with 5-HTP, suggest that an increased synthesis of 5-HT from its precursor 5-HTP might be a one factor responsible for differences in the serotonergic system between autistic post-pubertal youngsters and normal controls.
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There's a huge thread on this earlier somewhere....
 
I just recently started taking the 100mg daily and I was very skeptical at first but I do notice myself being more relax then before. The lady at GNC told me to take it at night. I tried doing that once and I woke up at 4:30 and I was WIDE awake. I also remember having some very strange dreams.

So I take it in the morning now and everything seems to be working out fine. im wondering how much more I could safely take to make the effects more evident
 
i take 100mg of 5htp every night to keep the migraines away. the recommend from the health food store is take it at night every night for 6 weeks, then take a week off. this helps keep your body naturally making serotonin. i hate taking that week off, but it helps long term with the migraines. btw, i used to roll once a month for the first 6 months when i first started 5 years ago, now i'm lucky if i roll once a year. no nonmeth sources where i live now :(.

during my week off of 5htp, i notcie that i don't sleep as well but only for the first night sometimes 2. also, i try not to ever have the week off right around that time of the month, because hormones for that are what trigger the migraines. it really sucks being a girl sometimes.
 
i take 5htp when my mood is down, it realy helps me.. its realy a great supplament to use. I never take it for longer then 2 -3 weeks at a time and i take 100mg before sleep. In the case of rolling ill up the dose to 200mg on say tuesday or wedsday when u are realy feeling like crap
 
I usually take 100mgs of 5-HTP a few days after dropping E. I think it softens the comedown; even if it doesn't, it at least provides a comfortable placebo effect. I might be imagining, but I think my serotonin levels rejuvenate blissfully quick. I once took 200mgs of 5-HTP more than three weeks after my most recent E experience and experienced a couple dizzying hours of painful headaches and unease. Lesson learned.
 
cucarot said:
so no body dare to plug it huh .hmm...it is much safer than plugging something else people . com'on now ....:p
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why the fuck would you plug it? it doesn't make you high or anything....

and BTW, my bottle of 50mg 5htp pills says to take one every day, so I doubt there's a problem with that
 
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