I think it depends on who is accepting of it.
I've had a lot of people turn their backs on me because I take one E-pill once every 6-9 weeks. I was even kicked out of my cast (I performed monthly in The Rocky Horror Picture Show). I had a guy I really liked find out and went on and on about how he couldn't date someone with 'a drug problem'. I've lost a lot of my old friends that I don't party with and have to deal with their 'pitying' looks when they do see me, or have them lecture me about how I am trying to kill myself and so on.
But at the same time, I've gained a lot of new friends through E and going to clubs with like-minded people.
Then again, I also used to pretend I was so tweaked out at work, because I hated my job. It made it more interesting, and it made interactions with the coworkers hilarious.