Is etizolam a mutagen/genotoxic or not and what of other benzoes?

[Tieeurrrop]

I always check that shit now since I found out what it means and avoid any drugs that are.

I read that some benzoes are genotoxic and some aren't. I read a paper at some point which listed xanax as one that isn't genotoxic and some others that are (forgot which ones were since I wasn't interested in taking them at the time but know that the z drug zopiclone was on the list of genotoxic ones).

Etizolam I can't find any information on in this regard. I have found genotoxic data for very obscure things in the past (mulungu for example) so it's strange I can't find info for this since it is a popular drug in some countries such as india.

And what about the other benzoes? I have found a study that did test genotoxicity of a slew of benzoes but the fucker was behind a paywall and the conclusion was not written in the abstract.

Anyway it is good to know xanax comes up clear on that front since it is the most widely used and one of the most easily available and suits the effect profile I like (fairly short half life) should I want to try it.

 

[dopamimetic]

Paywall --> https://sci-hub.se/

A quick Google search found me this: https://livertox.nih.gov/BenzodiazepineDrugs.htm

Benzodiazepine therapy is uncommonly associated with serum enzyme elevations, and clinically apparent liver injury from the benzodiazepines is quite rare. Alprazolam, chlordiazepoxide, clonazepam, clorazepate, diazepam, flurazepam and triazolam have been linked to rare instances of cholestatic liver injury but the other benzodiazepines have not. The absence of reports of this rare adverse event, however, may be due to the fact that these other benzodiazepines are not as commonly or continuously used. Alternatively, the use of the sleeping aids in intermittent and low doses may favor their lack of hepatic injury.

According to them, oxazepam doesn't share that toxicity and little is known about injuries caused by it.

An interesting non-benzo tranqulizier is etifoxine. There were some concerns about hepatotoxicity for that one too, yet it's been labelled as having very low incidence.

 

[polymath]

Oxazepam has to go through a smaller number of metabolic steps before it can be excreted in the urine, which may be why it has even smaller risk of hepatotoxicity than diazepam and others.

 

[Tieeurrrop]

Paywall --> https://sci-hub.se/

A quick Google search found me this: https://livertox.nih.gov/BenzodiazepineDrugs.htm


According to them, oxazepam doesn't share that toxicity and little is known about injuries caused by it.

An interesting non-benzo tranqulizier is etifoxine. There were some concerns about hepatotoxicity for that one too, yet it's been labelled as having very low incidence.

Ah I answered related stuff in my other thread I made which is right beside this. It has ended up that I would have repeated myself. Maybe they could be merged or maybe this one is redundant since there is no literature on the mutagenicity of etizolam so people would only be speculating but speculation? Since there are so many better studied and as widely if not more available benzoes out there maybe it is better to stick with them.