Misc Is "Ceiling Dose" a Real Thing?

[ChemicallyEnhanced]

I remember a few years ago on here, people were debating if Codeine had a ceiling dose and what it is.
Do some drugs have one? And if Codeine DOES, what is it? Because that could make sense. Like, Codeine is 1/10th the strength of Morphine, but I get a MUCHHH better buzz from 90mg Morphine than I do from 900mg Codeine.

 

[TheFunkeeJunkee]

Codeine is a special case as it's a pro-drug that requires hepatic metabolism. Codeine is metabolised into Morphine, as is Tramadol into O-DSMT. Only so much can be converted, so at a certain dose there is a "ceiling" effect. There are many other examples of inactive drugs that are metabolised into active drugs and many examples of active drugs that have active metabolites.

All drugs in theory have a ceiling effect although you'd likely be dead before you reached it.

 

[Dextro .45]

Yes. Obviously

Bupropion (Wellbutrin) has a ceiling dose of 450mg / to be safe

Many drugs have non, obviously....like Opioids. One person 20mg of Hydromorphone is too high, others whom are tolerant can be taking 120mg, 200mg, etc just an example. 500mg of Hydromorphone is used in Utah as capital punishment to execute people. Basically a massive Heroin OD after the Midazolam has taken effect

Lyrica (Pregabalin) 150/300-450mg is max recommended dose.....while people can take 700mg in a cocktail to get high

Generally.....the ceiling dose is maximum dose for either safety, or drug is only effective to that dose, then undesirable/dangerous adverse effects take place

Tylenol can be extremely dangerous when taken above certain doses