Is anyone here on Arimidex and antidepressants or Lamotrigine?

glab

Bluelighter
Joined
May 3, 2015
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I'm on TRT and my E2 is getting too high. Basically I needed Arimidex to lower it.
But the problem is I don't have a doctor who'd prescribe it to me and another problem
is that I don't know how Arimidex is metabolized and if there are any major drug interactions
with antidepressants (currently I'm on vortioxetine but I will probably move to Lexapro cause it
has fewer drug interactions) and I also want to start with Lamotrigine.

Does anyone know if Arimidex can be taken when you're on Lamotrigine? I don't want to risk anything.
In case if Arimidex somehow interfered with Lamotrigine and made its plasma levels rise up then it could
be dangerous.
 
I'm on TRT and my E2 is getting too high. Basically I needed Arimidex to lower it.
But the problem is I don't have a doctor who'd prescribe it to me and another problem
is that I don't know how Arimidex is metabolized and if there are any major drug interactions
with antidepressants (currently I'm on vortioxetine but I will probably move to Lexapro cause it
has fewer drug interactions) and I also want to start with Lamotrigine.

Does anyone know if Arimidex can be taken when you're on Lamotrigine? I don't want to risk anything.
In case if Arimidex somehow interfered with Lamotrigine and made its plasma levels rise up then it could
be dangerous.

Shouldn't be an issue...

http://www.medsafe.govt.nz/profs/datasheet/a/Arrow-Lamotriginetab.pdf
 
Hi, you mean because it does not mention arimidex in there?
But what if there are interactions between both and they are simply unknown cause few people take arimidex and lamotrigine at the same time?

And do you know how much arimidex I'd probably need to lower my E2?

I am getting T shots and my protocol really sucks. I am stuck with 250mg every 17 days. This sends my T up and down. But my endo doesn't do anything else.
The problem is that when I started with the injections my E2 was still normal around 23 pg/ml but now after a few months it's up to 47 pg/ml which is above the normal range!
I don't get a gyno but my libido is low and erections also suck and I also don't feel better mentally. I think it could be due to E2.

But even if I could get arimidex on my own I'd still need to know how much to take and wether I would have to cycle it. I know that when I get the injection my T peaks after 7 days and then
it goes down again.
Does this mean that I should cycle the arimidex and take a higher dose during the first 10 days and then a smaller dose when my T levels go down again?
 
I never understood why a dr knowing the esters of something would prescribe a dosage that doesnt respect the ester at all
 
Pharmaceutical companies generally know what compounds interact with their products.. stop worrying. ..
0.25mg EOD or every 3rd day or even twice a week should suffice. .
Test-e will peak after a few hours then taper off.. not 10 days..
why not ask your doctor to inject half the dose more frequently. For less of a plasma spike. .and subsequent aromatization. . ..
 
They both use similar enzyme metabolism systems (predominantly CYP), however both are common and if there were any adverse interactions or effects on blood levels it would have been reported many years ago.

What testosterone preparation is your doctor giving you? Cypionate, undecanoate? A more frequent schedule would of course be beneficial for you.

As said above, anastrozole at 0.25mg E3D would probably be adequate. I'd rather be towards the lower end of the range than at the top.
 
Hello, I get enanthate (sp?).

I have an andrology book and it has the charts in it and according to this book when you get 250mg enanthate you peak after 4-7 days and then you go down and after 2 weeks you're already at the bottom
of the normal range.

Does arimidex need to be cycled? Or should I take the same dose all the time? Or should I take a higher dose after an injection and then lower the dose before the next injection when my T levels are
already low again?

And how can I tell if arimidex works? I mean what kind of positive effects should I notice?

And what if my E2 gets too low? Do I need to supervise my E2 levels? From what I read too low E2 is also not good.
 
What is the name of this book? The peak with enanthate is generally accepted to occur within the first 24 hours (roughly 11% of the dose). You'd be at the bottom of normal range after about 7 days on a once-per week schedule.

You need a blood test to see what your estradiol level is at from using the anastrozole at our recommended dose. You'd need to adjust the anastrozole depending on the feedback from the tests.

You may not notice anything at all from controlling estradiol, though your sex drive may improve - it really depends on the person. Your main issue really is persuading your endo to inject the testosterone more frequently.
 
This is the book.

http://www.springer.com/us/book/9783540783541

In this book there is a chart where you see a comparison between 250mg Enanthate being injected every 7 days, every 14 days, every 21 days.

HERE you see the pic. Go to page 443.

https://books.google.de/books?hl=de...ate&redir_esc=y#v=snippet&q=enanthate&f=false



According to the pic 250mg every 2 weeks would keep you from going below the normal range but 2 weeks is too often my doc won't do this.
Every 17 days is the best I can get. This way my levels do not drop too far but I still have the E2 issue.
 
Unfortunately that picture doesn't show for me, possibly because it's viewable for Germany but not elsewhere?

Without being able to see it, it's hard to say much, but the book itself should be accurate.

Are you unable to discuss injecting it yourself with your endo? They will sometimes let you take it home and do it yourself.
 
Try this link

https://books.google.com/books?hl=d...ate&redir_esc=y#v=snippet&q=enanthate&f=false

When you scroll down you should see the different pages.

---

I asked my endo he does not allow SI and he also doesn't do other protocols. Endos really suck and hardly know anything about TRT it's really sad.


But what's your opinion on this here:

Stable T levels would be the best, this is clear.
But compared to having low testosterone is it still better to get injections which cause ups and downs but overall your T levels are still higher than without TRT?
I mean doesn't the body still profit from having more testosterone as long as I can keep the E2 under control?
 
Still doesn't work for me unfortunately.

Anyway to your question yes I would think controlling oestrogen would help even without any changes in injection frequency. It's certainly worth trying and should help keep the ratios between E2:Test more stable.
 
Ok thanks.

And should I take arimidex all the time or cycle it?

And does it have any really scary side effects? I don't know anything about this drug and how hard it is on the body. I hope it's nothing too hardcore cause if it has too many
side effects then I might not dare to take it.
 
Although anastrozole has a pretty decent long-term safety profile, due to thousands of women who have to use it as a breast cancer treatment, with very few side-effects (particularly so in men) I would never advise anyone to take a medication all the time without their doctor's guidance or approval.

If you'd like to find out more - and I do advise that you do - the basic Wikipedia article is a decent summary.

Having said that, I was under the impression your goal in the first instance was just to experiment with it and see if it helps? If it doesn't help you subjectively, then there's probably no point in taking it anyway.

So I advise you try it first and assess after a few weeks to a month whether it's improved anything. As said before, start at a conservative dose of 0.25mg every third day. On the basis of future blood tests, you can then titrate the dose up or down depending on your E2 level.
 
Hi, yes first of all I'd try it for a while and then see if it makes TRT more effective because I don't really notice much from the TRT. I don't have a higher libido and also hardly any morning wood.
And I also don't put on lean mass. And I still have the same feminine looking fat distribution pattern. I was hoping that getting on TRT would change my body composition so that I look at least
a bit masculine. If it doesn't do that then what's it good for?
Maybe the problem is that my E2 is too high. Is this possible?
Or would high E2 not negatively affect anabolism? I mean if you have high T and high E2 then would you still be in an anabolic state and put on muscle mass or would the high E2 ruin it?

And what does Arimidex actually do? Does it block T from being converted into E2 or does it also keep the body from producing own E2?

Does it also protect you against environmental estrogens like in plastics and stuff like that?
 
Hi, yes first of all I'd try it for a while and then see if it makes TRT more effective because I don't really notice much from the TRT. I don't have a higher libido and also hardly any morning wood.
And I also don't put on lean mass. And I still have the same feminine looking fat distribution pattern. I was hoping that getting on TRT would change my body composition so that I look at least
a bit masculine. If it doesn't do that then what's it good for?
Maybe the problem is that my E2 is too high. Is this possible?
Or would high E2 not negatively affect anabolism? I mean if you have high T and high E2 then would you still be in an anabolic state and put on muscle mass or would the high E2 ruin it?

And what does Arimidex actually do? Does it block T from being converted into E2 or does it also keep the body from producing own E2?

Does it also protect you against environmental estrogens like in plastics and stuff like that?

-Your adipose tissue will most likely be the last thing to finally go considering the speed at which excess fat is utilized for energy demands. However once your testosterone levels are within appropriate range there should a slight increase in the elimination of that excess fat. Proper diet and exercise will give you the best results and would be marginally faster than relying on testosterone alone.

-LBM does take time to create, but the more you gain in muscle the more metabolically active you become. This will also help accelerate the utilization of fat for energy.

I was hoping that getting on TRT would change my body composition so that I look at least a bit masculine. If it doesn't do that then what's it good for?

-TRT is the replacement of your endogenous testosterone production. Its only there to replace the lack of production, but it is not there to create a supraphysiological environment that others strive for when administering larger doses. You cannot rely on the steroid to do all the work. Think of the TRT as a tool to give you the advantage in your efforts to bring your body composition back to its previous state before you experienced HPTA dysfunction. What is TRT good for? If you don't have the proper serum levels of testosterone you will not want to live. Testosterone is the reason we feel the way we feel in regards to being a male. That should be a good enough reason without going deeper.

-High or low estradiol can result in diminished libido. You want a respectable quantity of E2 in your body to maintain the biological processes that rely on its presence (lubrication of joints, anti-inflammatory, sex drive)
CFC stated earlier a recommendation of where you should start for your anastrozole dosage. If you happen to still have an E2 level that is not within optimum range than increase the dosage by another 0.25mg.

Anastrozole is an aromatase inhibitor, but it is only a partial antagonist. This means it reduces the activity at which testosterone is converted into estrogen without completely turning off the enzymes activity.

No the AI is only there to regulate Testosterone>oestrogen conversion. It does not have any influence over environmental estrogens you may come into contact with.
 
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Thanks Grym.

Is 0.25mg the smallest possible dose one can take? Can the pill be divided into 4 pieces or how does this work?

Could I also try out 0.125mg or simply prolong the intervals in which I take my doses? Or is 0.25mg the minimum dose and if you take less
than that you also won't get any noticable effect?

And how can I tell if my E2 is too low? My libido is low even though I'm on TRT. If I went to Arimidex then should it go up as a sign that it's working?
 
Thanks Grym.

Is 0.25mg the smallest possible dose one can take? Can the pill be divided into 4 pieces or how does this work?

Could I also try out 0.125mg or simply prolong the intervals in which I take my doses? Or is 0.25mg the minimum dose and if you take less
than that you also won't get any noticable effect?

And how can I tell if my E2 is too low? My libido is low even though I'm on TRT. If I went to Arimidex then should it go up as a sign that it's working?

I've tried to use a pill cutter from work but the adex tablets are that small its almost impossible to accurately cut halves, I've had better success with a sharp knife..

You will be fine with 0.25mg, Try taking your adex on the day of injection then 3 days later, see how you go and after a few weeks take a blood test to see where E2 is at, raise or lower the dose to suit...

E2 should be within range, low E2 can be just as bad as high E2 for reduced libido...
 
Thanks for the advice.

But let's say I use a dose of 0.25mg and then have my E2 measured after 7 days when my T levels are at their highest then
this only tells me what my E2 levels are like when my T peaks.

What if for example my E2 is at 20 when the T is at its highest and I think everything is alright but then when my T levels start to drop
after 7 days my E2 levels also go down and go too low? How shall I find out if my E2 levels are within the desired range ALL the time during the
3 week cycle? I mean I cannot get blood drawn every 7 days to supervise my E2 levels my doc wouldn't agree with this.

And even if I had E2 measured weekly to see what my levels are during 1 full cycle then what if the E2 levels can still simply start to behave differently
a few weeks later?

I don't think that it's very realistic to assume that if I stay on the same arimidex dose all the time that my E2 levels will also be the same all the time.

What if for example antidepressants or other drugs which are metabolized through CYP in the liver could also totally affect E2 levels? This would makes this
whole thing even more complicated. Then even if I had found the right arimidex dose it could still all change as soon as I start adding another drug.
 
But let's say I use a dose of 0.25mg and then have my E2 measured after 7 days when my T levels are at their highest then
this only tells me what my E2 levels are like when my T peaks.

Not really no. There is a reasonable degree of lag between T levels and E levels, both in terms of its conversion and it's release from SHBG, and E also generally has a longer half-life. So assuming your input of testosterone follows a consistent pattern, although your E will vary, it will be the more stable of the two.

I don't think that it's very realistic to assume that if I stay on the same arimidex dose all the time that my E2 levels will also be the same all the time.

Your E levels will remain stable enough for your purposes. There is no particular reason to even try and achieve totally unchanging oestrogen levels - that would be essentially the most unnatural thing to do. The body ordinarily experiences peaks of troughs of almost all hormones. Sometimes that variation is an essential part of the hormone's function.

What if for example antidepressants or other drugs which are metabolized through CYP in the liver could also totally affect E2 levels? This would makes this
whole thing even more complicated. Then even if I had found the right arimidex dose it could still all change as soon as I start adding another drug.

You'd have to be experiencing quite significant liver failure for any variation induced by common medicines to have a functional impact on E levels. And again, there is no scientific rationale for attaining utterly stable E levels. What has been proposed is likely to be suitable for your needs. Since what you are planning to do is in essence an experiment, with negligible risks from 'failure', you can't expect everything to be rigidly controllable. If this uncertainty worries you too much, I strongly advise you to simply not do it.
 
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