therealog
Greenlighter
Now I know eating it 30mins prior prolongs your high but would mixing it in your shot work too?
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OD Moderators: Keif’ Richards | negrogesic
Misc injecting cimetidine with your opiate
- Thread starter therealog
- Start date
Psychedelic Jay
Bluelighter
If you do pursue it, you will need heavy filtering...
This isn’t a cotton filter type situation...
Make sure you know the drugs solubility before you go for it, as well as the solubility of the in-actives...
This isn’t a cotton filter type situation...
Make sure you know the drugs solubility before you go for it, as well as the solubility of the in-actives...
cimitidine is expensive compared to other OTC meds at the pharmacy. please just go buy more smack or hydromorphone. dont waste your time and money and most definitrly uour body trying to inject tagamet
i have been injecting opiates/cocaine for 4 months straight, up to 6-10 shots a day. injecting shit is about th RUSH, and tagamet wont intesify the rush, only the duration of effects. thats why it seems pointless to inject tagamet because there would be no extra RUSH . and thats what we want... no??
i have been injecting opiates/cocaine for 4 months straight, up to 6-10 shots a day. injecting shit is about th RUSH, and tagamet wont intesify the rush, only the duration of effects. thats why it seems pointless to inject tagamet because there would be no extra RUSH . and thats what we want... no??
Psychedelic Jay
Bluelighter
I would think that the OP is trying to kill two birds with one stone, so to speak... Same rush longer duration...
But, I fear that a waste of time and drugs might be unavoidable if the right knowledge is not applied.
It would be easier and less time consuming to just eat your cimitidine...
cimitidine wont extend your rush. the only way to extend your rush is to increase the amount of drug consumed. the duration is directly correlated with concentration, the rush of shooting up comes from the extremely fast conversion of your drug of choice into dopamine and endorphins. more dope = more dopamine = better, faster, stronger rush.
theoretically to manipulate the rush's duration and intensity without simply taking more of a drug, you have to hasten the rate-determining step in which the drug is converted into 'feel good' neurotransmitters(or add a catalyst/enzyme to decrease activation energy). the slowest step of the reaction determines how fast the whole series of mechanisms or overall reactions take place.. usually, the faster the drug passess through the blood-brain barrier, the more intense the rush is. for example, heroin and cocaine both have amazingly awesome abilities to pass through the BBB with such ease which allows for the most extreme and pleasurable rush. basically to my understanding, for a drug to have a "rush", the reaction that takes place during passage through the BBB into the CNS MUST be faster than the slowest step that occurs throughout the whole series of reactions. this would only make sense because this postulation correlates well with the idea that to increase the concentration of heroin/cocaine, you increase the intensity/duration of effects.
cimitidine, and im talking out of my ass here, mainly affects the peripheral systems such as liver enzymes and NOT the Central Nervous System (CNS). the rush that takes place when a user injects a drug happens solely in the CNS, the rapid and almost instantaneous conversion of the drug happens in your brain which is the CNS. this is where monoamine oxidase breaks down heroin molecules into mainly morphine molecules which then bind to opiate receptors and thus the rush takes place. afterwards, the drug passess through the liver, which would where tagamet/cimitidine would come in. note this is AFTER the rush is good and done with, but the drug is still felt.
lets say you inject heroin+cimitidine. essentially, the heroin would pass the BBB much quicker than the cimitidine (if cimitidine EVEN CROSSES THE BBB AT ALL) and the reaction (rush) would occur. after that blissful rush (who knows how long) then the cimitidine would FINALLY kick in and prevent the degradation of the morphine molecules.
i think it would be impossible to add a catalyst to the CNS, and i think it would be impossible to shorten the time it takes for a drug to pass through the BBB by taking another psychoactive substance/.
theoretically to manipulate the rush's duration and intensity without simply taking more of a drug, you have to hasten the rate-determining step in which the drug is converted into 'feel good' neurotransmitters(or add a catalyst/enzyme to decrease activation energy). the slowest step of the reaction determines how fast the whole series of mechanisms or overall reactions take place.. usually, the faster the drug passess through the blood-brain barrier, the more intense the rush is. for example, heroin and cocaine both have amazingly awesome abilities to pass through the BBB with such ease which allows for the most extreme and pleasurable rush. basically to my understanding, for a drug to have a "rush", the reaction that takes place during passage through the BBB into the CNS MUST be faster than the slowest step that occurs throughout the whole series of reactions. this would only make sense because this postulation correlates well with the idea that to increase the concentration of heroin/cocaine, you increase the intensity/duration of effects.
cimitidine, and im talking out of my ass here, mainly affects the peripheral systems such as liver enzymes and NOT the Central Nervous System (CNS). the rush that takes place when a user injects a drug happens solely in the CNS, the rapid and almost instantaneous conversion of the drug happens in your brain which is the CNS. this is where monoamine oxidase breaks down heroin molecules into mainly morphine molecules which then bind to opiate receptors and thus the rush takes place. afterwards, the drug passess through the liver, which would where tagamet/cimitidine would come in. note this is AFTER the rush is good and done with, but the drug is still felt.
lets say you inject heroin+cimitidine. essentially, the heroin would pass the BBB much quicker than the cimitidine (if cimitidine EVEN CROSSES THE BBB AT ALL) and the reaction (rush) would occur. after that blissful rush (who knows how long) then the cimitidine would FINALLY kick in and prevent the degradation of the morphine molecules.
i think it would be impossible to add a catalyst to the CNS, and i think it would be impossible to shorten the time it takes for a drug to pass through the BBB by taking another psychoactive substance/.
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Unless you have access to IV/IM prepped cimetidine, I don't see why you would want to do this. The dosage required to inhibit liver enzymes effectively is 800mgs give or take, which is several of those little pills, which contain loads of binders. It would be pointless anyway, as it takes a bit for the drug to produce effects, so injecting it with your opioid would be pointless. It works just fine orally, just eat the damn pills 30 mins to an hour before dosing your opioid of choice 
ErgicMergic
Bluelighter
Just pop the cimetidine orally 45min to an hour before taking your opioid shot, and it work a lot better for the purpose you are using it for. Please don't inject cimetidine... 
mydrugbuddy
Bluelighter
Cimetidine isnt expensive. Indian pharms sell 100 400mg pills for about £10. (Apo- Cimetidine brand.)
As others have said its a pointless danger to inject it. Just swallow the pill half an hour before hand.
As others have said its a pointless danger to inject it. Just swallow the pill half an hour before hand.
therealog
Greenlighter
Ok ok flame central. I was jw. And lacster iv been speedballin on ds every day basically too for several months. We are going to pay in the end don't ya think?
morphonorconic
Bluelighter
Oh my Lord... Don't inject cimetidine with your dope.
You may have a misconception about how cimetidine works, but basically it needs to be ingested orally to inhibit certain enzymes in your digestive system that are responsible for metabolizing opioids and many other drugs as well. It doesn't synergize directly with anything, but rather slows the bodies ability to break things down, resulting in prolonged and often intensified effects.
And I know you are going to pay in the end. Everyone does. Be safe.
You may have a misconception about how cimetidine works, but basically it needs to be ingested orally to inhibit certain enzymes in your digestive system that are responsible for metabolizing opioids and many other drugs as well. It doesn't synergize directly with anything, but rather slows the bodies ability to break things down, resulting in prolonged and often intensified effects.
And I know you are going to pay in the end. Everyone does. Be safe.
therealog
Greenlighter
Sorry, but cimetidine comes in iv form.