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  • N&PD Moderators: Skorpio | someguyontheinternet

Indatraline HCl

Then you assume wrong my friend => Indatraline is highly potent. I have a document on my computer dealing the chemistry of this totally synthetic compound. I'd just like to point out that indatraline itself does not start hitting the right buttons until after N-demethylation in-vivo. Current studies have worked towards moving away from NMe2 and using different R groups. Hence why indatraline is coined a slow-onset, long duration SNDRI.
 
Hmm, I will never understand how scientists pick the doses they do for animal studies...


How potent is 'highly' potent? If its not nano's it fails to fit my definition of 'highly' so perhaps you could elaborate a slight amount?



SNDRI ive yet to hear that term, I assume Sero/Norepi/Dopa reuptake inhibitor is what that means?

In that case, is there any SNDRI's that are active in the mcg lvls, meaning not xxxMCG/KG but as in xMCG per 100kg, with prolonged duration vs. gods dandruff, that youd care to share?? :D
 
I thought this might happen. That's why I said highly potent eg 3-10mg (just guessing). If i'd said extremely potent then i'd probably be referring to something sub-nanomolar. There is a recent patent explaining a compound loop-the-loop in terms of potency and structure. This is the patent number but i'll leave it to you to sniff the compound out that I am referring to: WO2005041875.
 
doesn't look like there is much info on the oral bioavailability of indatraline.
 
It's structurally very similar to sertraline, so the sertraline bioavailability might give some hints.

Indatralin is not suitable as a recreational drug. The onset is very slow, and then the effect lasts forever. Very bad properties for a stimulant.

Lots of useful information on it can be found in JPET 291:60–69, 1999 (full text online free, www.jpet.org).
 
It' quite possible to do a chemical N-demethylation in-vitro to get a more rapid onset of action. Cant think of the reagent of the top of my head although it is highly chlorinated. I'd just like to sample indatraline to see what it is like. People put compounds onto the black market to get money from them, and i dont think indatraline is cost effective in this regard. But from the POV of a pharmaceutical company it would be but it is doubtful that it will be approved. However a RC supplier could wack samples out overnight but since the compound is patented i guess the general public wont get an opportunity to find out about it.
 
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