Pharmacology Implant device detects signs of opioid overdose and automatically administers narcan

[Quasimoto]

This is quite interesting. I'm not that surprised it was invented, out of necessity, but my main question is about cost and practicality. How is this ultimately going to benefit the average user if they can't afford it?

Interesting topic nonetheless.

It correctly responded to and reversed overdose in 24 out of 25 pigs.

Implantable device responds to opioid OD — Harvard Gazette

The iSOS monitors vital signs, delivering naloxone automatically and rapidly when it detects an overdose.

news.harvard.edu

 

[Skorpio]

Interesting.

I have two thoughts. 24 out of 25 pigs isn’t good enough for a medical device. I hope they can improve on the design with time so it gets approved.

The other thing, is how often does it incur false positives? If it can’t reliably differentiate between normal use and an overdose, then compliance will be low. Even if it only was triggered when somebody went on the nod, it would probably lose users.

 

[someguyontheinternet]

Did those pigs have a tolerance? What was the method used to detect overdose? I suppose I should read the article before typing all of this out

Edit: they monitor breathing and heart rate and when it drops below a threshold they administer. That actually sounds pretty solid to me

 

[Jnowhere]

Did those pigs have a tolerance? What was the method used to detect overdose? I suppose I should read the article before typing all of this out

Edit: they monitor breathing and heart rate and when it drops below a threshold they administer. That actually sounds pretty solid to me

We agree on something, I hope that is not some weird omen.

 

[Didgital]

Poor pigs

 

[Jnowhere]

Poor pigs

it is sad, all that bacon, sausage and pork chops going to waste.

 

[burn out]

Interesting.

I have two thoughts. 24 out of 25 pigs isn’t good enough for a medical device. I hope they can improve on the design with time so it gets approved.

The other thing, is how often does it incur false positives? If it can’t reliably differentiate between normal use and an overdose, then compliance will be low. Even if it only was triggered when somebody went on the nod, it would probably lose users.

I don't think it would be indicated for every opioid user, but I am sure there are some users who would be interested in such a device, especially with the advent of fentanyl contamination being so widespread.

 

[ChemicallyEnhanced]

This is quite interesting. I'm not that surprised it was invented, out of necessity, but my main question is about cost and practicality. How is this ultimately going to benefit the average user if they can't afford it?

Interesting topic nonetheless.

It correctly responded to and reversed overdose in 24 out of 25 pigs.

Implantable device responds to opioid OD — Harvard Gazette

The iSOS monitors vital signs, delivering naloxone automatically and rapidly when it detects an overdose.

news.harvard.edu

Great idea, but I feel like a lot of people wouldn't wanted it in case it stopped them getting high or "high enough" or in case it sent them into precipitated withdrawal. People don't like not being in control. Like, I could have a free implant that automatically detects my blood sugar levels and administers insulin, but I don't want it because of the lack of control and because I'd get fat.

 

[someguyontheinternet]

Great idea, but I feel like a lot of people wouldn't wanted it in case it stopped them getting high or "high enough" or in case it sent them into precipitated withdrawal. People don't like not being in control. Like, I could have a free implant that automatically detects my blood sugar levels and administers insulin, but I don't want it because of the lack of control and because I'd get fat.

My family member was fat before he got his CGM. That shit was not stopping him. He just manually injected insane amounts of jnsulin after eating boatloads of sugar and not to mention I think he can adjust his CGM now

This implant detects when breathing and heart rate are dangerously low which doesn't happen unless you're in a dangerous situation. Someone addicted to opiates who suddenly slows to 1 breath per minute and 25 BPM heart rate isn't just "too high" they're likely about to die

 

[ChemicallyEnhanced]

My family member was fat before he got his CGM. That shit was not stopping him. He just manually injected insane amounts of jnsulin after eating boatloads of sugar and not to mention I think he can adjust his CGM now

This implant detects when breathing and heart rate are dangerously low which doesn't happen unless you're in a dangerous situation. Someone addicted to opiates who suddenly slows to 1 breath per minute and 25 BPM heart rate isn't just "too high" they're likely about to die

I know with the opioid stuff, I just mean, like, with the way some addicts think, THEY wouldn't want the implant for that reason, even if it's wrong. Sorry, am I making sense? I'm really high.

Well, yeah, if you eat a lot of calories (and then use insulin so that your body actually *absorbs* them), you'll get fat.
What type is he?

I'm generally very good with my insulin now, since I had DKA in December and felt so horribly ill it gave me the kick up the butt I needed to start using my insulin properly. I just find a...comfort, I guess...in knowing that if I DO gain weight, or overeat on a regular basis again, I can either not take insulin, or reduce the amount I take. I used to do it all the time, 'cause (not sure if it's the same with people who are type 2) if you omit the insulin, you can eat as much as you want of whatever you want and lose weight fairly rapidly.
Does terrible damage to your body, though, which is why I stopped.