If me/cfs is a channelopathy, how to treat?

[copium7777]

 

[Jabberwocky]

links with no accompanying information or introduction aren't really useful and i personally wouldn't other clicking on something someone didn't even bother to explain to me. would you like to say what the thread/discussion you were hoping to start is about?

 

[copium7777]

Sorry for not elaborating, I thought the post I linked to was p thorough and I've been tired and away from service for awhile. This is a strong claim that me/cfs is a channelopathy, a disease that has something to do with dysfunction of ion channels in cells specifically. I guess this kind of dysfunction would make sense for a metabolic disorder that has heart symptoms, like pots, bc if would cause issues with cellular stress and also electrical conduction issues in the heart.

The specific claim seems to be that me/cfs involves trpm3 antagonism, which is causing low intracellular calcium. This interests me bc based in other aspects of its pharmacology I thought xenon might be helpful in me/cfs, since it lowers glutamate and has neuroprotective effects, but it is a trpm3 antagonist which based on this theory could make me/cfs worse. And which would be a big waste of money lol ....

 

[copium7777]

My main thought is that trpm3 is probably somewhat downstream of the main cause of me/cfs