Stimulants I did meth for 4 days,Am I gonna be depressed now?

[kilo777]

I did meth for the last 4 days, but I got sleep every night, i'd wake up and i'd smoke a hit every couple hours....

I've done meth before but only once prior to this....

Did I screw up my dopamine/serotonin receptors or anything like that? Am I gonna have to go week's feeling like crap? Did I cause brain damage that will make me unhappy for awhile?

Im not gonna do meth again... For the come down I have Gabapentin (which is one of the drugs used in the expensive 'Prometa' detox program).

I just dont want this 4 day meth smoking to destroy my happiness and make me nonsocial or anything like that....

 

[x719]

bro shouldnt you look all this up before using meth in a binge? its best to know what ur using before you use it.. not oh shit am i okay? after using.. just food for thought.. i dont know much about meth but someone will chime in soon.

 

[dokomo]

Methamphetamine (at recreational doses) is neurotoxic to dopaminergic neurons in the brain. When its abused, these neurons become damaged and die off or fail to function correctly.

Its difficult to quantify this damage in practical terms, but suffice it to say you're a little closer to parkinsons disease every time you abuse methamphetamine. This is because it is neurotoxic to dopaminergic neurons in the substantia nigra.

 

[kilo777]

Methamphetamine (at recreational doses) is neurotoxic to dopaminergic neurons in the brain. When its abused, these neurons become damaged and die off or fail to function correctly.

Its difficult to quantify this damage in practical terms, but suffice it to say you're a little closer to parkinsons disease every time you abuse methamphetamine. This is because it is neurotoxic to dopaminergic neurons in the substantia nigra.

I'm aware of that, but wouldn't it take a little bit of abusing meth, or using it a good few time's or for a long period of time for it damage your neurons....

I did it for 3 days and slept every night, just was high during the day time...

I'm pretty sure I didn't do any damage because now, im feeling fantastic... Almost like the meth refreshed me and reminded me of the goals I want to accomplish

 

[hydrochron]

Your fine. You might feel a little slow and tired. But shouldn't fall into a deep depression. Usually after the come downs over and you get a good sleep you'll feel great being off the shit. Almost like another come up but a natural one aha.

 

[dokomo]

I'm aware of that, but wouldn't it take a little bit of abusing meth, or using it a good few time's or for a long period of time for it damage your neurons....

I did it for 3 days and slept every night, just was high during the day time...

I'm pretty sure I didn't do any damage because now, im feeling fantastic... Almost like the meth refreshed me and reminded me of the goals I want to accomplish

It damages/destroys neurons every time you use it. It just takes repeated use before this damage accumulates to the point where you actually manifest outward physical symptoms. How you subjectively 'feel' at the moment doesn't have much to do with the type of damage it does in the brain

I previously mentioned the substantia nigra - it is an area of the brain containing a large concentration of dopaminergic neurons, and is involved in movement, addiction, reward, etc. Individuals with parkinson's disease experience a spontaneous death of large amounts of these neurons, eventually resulting in outward physical symptoms.

We naturally lose 0.5-1% of these neurons each year we age, and it takes approximately an 80% loss to exhibit parkinsonian symptoms. When you take methamphetamine (or other neurotoxic stimulants, such as methcathinone) you accelerate the loss of these neurons dramatically. This is just one area in the brain/body where dopaminergic neurons are damaged when methamphetamine is abused.

 

[Pharmokinetictal]

So. I'm not discounting anyone's points here. They're all valid. They just depend on the way the drug was administered, for how long, and at what dose. Methamphetamine is not, innately, a bad drug, per se. At least not much more than Adderal (d/l amphetamine). MDMA has similar effects to the serotonergic and dopaminergic neurons in that it downregulates the transporter enzymes in the synaptic cleft...eventually leading to lower transmission of the essential neurotransmitters that your brain relies on to learn, form memories etc.

Dokomo is correct that the use of amphetamines DOES damage neurons. This is because of the unique nature of amphetamines (ritalin, dexedrine, vyvnase, adderal, meth) in how they not only increase the amounts of serotonin, dopamine, and norepinephrine in the synaptic cleft by inhibiting their respective transporters, but by also reversing transport of these 'monoamines' from the pre-synaptic neuron to the the post synaptic neuron. Casually speaking, it 'shreds' these neurons and its still unclear as to whether these neurons can recover. There's substantial evidence that they do to some extent with the help of natural peptides like BDNF and NGF in our brains. It's a myth that brain cells do not recover, even if we lose them with age.

That's more scientific. I agree with Dokomo, although I believe the Ventral Tegmental Area is more involved with the mesolimbic reward pathway in terms of the concentration of dopamine activity but that is irrelevant.

The point is...if you've done it for 3 days and you used it relatively responsibly (I would avoid IV or smoking)...you shouldn't experience any symptoms other than minor fatigue and more vivid dreams. Maybe a slightly slump in energy. I don't recommend amphetamines to anyone because of their unique properties but if you feel you need them, I would seek a psychiatrist. Meth is too strong. Adderal will not necessarily give you the same high but it will achieve the same sense of determination you seem to be looking for. Get a prescription and DO NOT abuse it. Amphetamines are dangerous in the long run.

 

[dokomo]

Dokomo is correct that the use of amphetamines DOES damage neurons. This is because of the unique nature of amphetamines (ritalin, dexedrine, vyvnase, adderal, meth) in how they not only increase the amounts of serotonin, dopamine, and norepinephrine in the synaptic cleft by inhibiting their respective transporters, but by also reversing transport of these 'monoamines' from the pre-synaptic neuron to the the post synaptic neuron. Casually speaking, it 'shreds' these neurons and its still unclear as to whether these neurons can recover. There's substantial evidence that they do to some extent with the help of natural peptides like BDNF and NGF in our brains. It's a myth that brain cells do not recover, even if we lose them with age.

That's more scientific. I agree with Dokomo, although I believe the Ventral Tegmental Area is more involved with the mesolimbic reward pathway in terms of the concentration of dopamine activity but that is irrelevant.

Not all amphetamines are neurotoxic, and some are CERTAINLY more neurotoxic than others. Methamphetamine, for example, is far more readily neurotoxic than amphetamine. Methylphenidate (as you listed) has been repeatedly tested and shown not to cause neurotoxicity.

Some neurons can be regenerated, but this is highly dependent upon the structure and area. Relevant to my points, the current body of research suggests that neurons in the substantia nigra do not regenerate. Only one study (to my knowledge) has displayed evidence that these particular neurons regenerate, and even in this study it was at a rate of 20 cells per day.

This is a PET scan showing the extent of damage that use can cause. Note that when these scans were taken, the methamphetamine user had been completely off of the drug for 3 years, as had the methcathinone user. To the far right is an individual newly diagnosed with parkinsons disease.

 

[rbeardedone]

I think you were probably a little tweaked when you posted this. If it does ever happen again stop worrying and enjoy your buzz, what's done is done, you've already paid the price might as well not ruin it. Although I wouldn't suggerst doing this and after awhile for me anyway it got to where I had to have a couple miligrams of xanax just to enjoy meth and it escalated from there. It's not a pretty road I'll go a head and let you know.

 

[shadowkid717]

So. I'm not discounting anyone's points here. They're all valid. They just depend on the way the drug was administered, for how long, and at what dose. Methamphetamine is not, innately, a bad drug, per se. At least not much more than Adderal (d/l amphetamine). MDMA has similar effects to the serotonergic and dopaminergic neurons in that it downregulates the transporter enzymes in the synaptic cleft...eventually leading to lower transmission of the essential neurotransmitters that your brain relies on to learn, form memories etc.

Dokomo is correct that the use of amphetamines DOES damage neurons. This is because of the unique nature of amphetamines (ritalin, dexedrine, vyvnase, adderal, meth) in how they not only increase the amounts of serotonin, dopamine, and norepinephrine in the synaptic cleft by inhibiting their respective transporters, but by also reversing transport of these 'monoamines' from the pre-synaptic neuron to the the post synaptic neuron. Casually speaking, it 'shreds' these neurons and its still unclear as to whether these neurons can recover. There's substantial evidence that they do to some extent with the help of natural peptides like BDNF and NGF in our brains. It's a myth that brain cells do not recover, even if we lose them with age.

That's more scientific. I agree with Dokomo, although I believe the Ventral Tegmental Area is more involved with the mesolimbic reward pathway in terms of the concentration of dopamine activity but that is irrelevant.

The point is...if you've done it for 3 days and you used it relatively responsibly (I would avoid IV or smoking)...you shouldn't experience any symptoms other than minor fatigue and more vivid dreams. Maybe a slightly slump in energy. I don't recommend amphetamines to anyone because of their unique properties but if you feel you need them, I would seek a psychiatrist. Meth is too strong. Adderal will not necessarily give you the same high but it will achieve the same sense of determination you seem to be looking for. Get a prescription and DO NOT abuse it. Amphetamines are dangerous in the long run.

I used to be a heavy tweaker and i agree with you on this one.

I was one of the few who learned to sleep eat and function on meth (Tina, ice crystal, whatever youd like to call the bitch).

I was a smoker, and its very orally fixating. I still miss it greatly, i dont miss snorting it really at all, its all about the "pipe ritual".

Anyways, youll be okay, i just wouldnt recommend doing it ever again. Its easy to get hooked on especially if you do smoke it.

But everyones different, i have been clean for 6 months from tina (meth) and i wish i was still using. I miss it greatly, but its not in this area anymore and im not totally devastated its gone.

It all depends on the person, and how much that person likes a certain substance and how it was administered and how frequently it was used.

 

[Lopez]

hell i get suicidal after ONE day of ADDERALL. varies from person to person, i'm more susceptible to crashes. you may or may not crash is all i can say...

 

[orange floyd]

hell i get suicidal after ONE day of ADDERALL. varies from person to person, i'm more susceptible to crashes. you may or may not crash is all i can say...

I've noticed that before i ever really rolled, i could speed out days in a row (always sleeping a few hours) to little ill effect. After a six month period of rolling anywhere between 3 times a week to every 3 weeks, i tried to eat adderall months after i wasn't feeling too e-tarded anymore. Now it feels more like a roll than speed, and i crash out HORRIBLE the next day, even off 20mg. Worse day after effects than i even get from rolling, or when i'd do high doses of amp for days on end. Could MDMA have effected my dopamine or serotonin system in a way making amphetamine no longer as pleasurable permanently? I no longer use MDMA and i'm pretty sure adderall still has this negative effect, dexedrine doesn't treat me too bad tho.

 

[Captain.Heroin]

Methamphetamine (at recreational doses) is neurotoxic to dopaminergic neurons in the brain. When its abused, these neurons become damaged and die off or fail to function correctly.

Damaged neurons can recover, however; it is an outdated idea that all damaged neurons die or will never recover.

To the OP's question, I would expect to feel a little shitty or tired for at least a day. If you don't feel the best that day, try to stay positive, because you'll start feeling better in no time.

The biggest factors for recovering are: eating food and drinking water, sleeping, and exercising.

Also, brush your teeth, and try to avoid harmful drugs like tobacco and alcohol as I am pretty sure these exacerbate methamphetamine comedowns.

 

[OpiYum]

not necessarily.

^agree with C.H. brush ur teeth, floss, shower, drink lots of water, eat green vegetables, sleep, take a walk.

u should be fine. a 2 week bender I'd be more concerned about.

 

[dokomo]

Damaged neurons can recover, however; it is an outdated idea that all damaged neurons die or will never recover.

If you'll read all of my posts in the thread, I say very clearly that I am referring to the dopaminergic neurons in the substantia nigra, not making a blanket statement about all neurons.

Many times, damaged neurons are repaired and continue to function, but function less efficiently. By and large, though, neurogenesis happens on a small scale and only in certain areas of the brain.

 

[Captain.Heroin]

If you'll read all of my posts in the thread, I say very clearly that I am referring to the dopaminergic neurons in the substantia nigra, not making a blanket statement about all neurons.

Many times, damaged neurons are repaired and continue to function, but function less efficiently. By and large, though, neurogenesis happens on a small scale and only in certain areas of the brain.

Yes, I have noticed that you weren't referring to all neurons, that's correct.

However, we are learning more and more about the brain and how it recovers, and I would say that neurogenesis does happen more than we have realized in the past.

I could expand upon this but I'm going to find out if I can find some material to demonstrate.

 

[dokomo]

Yes, I have noticed that you weren't referring to all neurons, that's correct.

However, we are learning more and more about the brain and how it recovers, and I would say that neurogenesis does happen more than we have realized in the past.

I could expand upon this but I'm going to find out if I can find some material to demonstrate.

I'd like to think that it does occur widely, but right now the research simply doesn't bear that out. The subventricular region responsible for generating new olfactory cells is one example where this occurs, and the subgranular region of the dentate gyrus in the hippocampus (involved in memory formation) are the two main areas where neurogenesis occurs to a significant degree.

There are individual studies that point to some measure of activity in other areas, but the data are shaky at best, as it can be difficult to differentiate neurons from glia.

It could occur more than this, but its really just speculation. The data simply do not reflect widespread neurogenesis.

 

[nuke]

I never really felt hugely depressed after serotonergic neurotoxin administration -- just weird and dissociated for a few weeks. Like I'm not myself, or something. Then after a few months it was always back to normal.

 

[sniperhavoc]

Get some L-tryptophan or 5-htp which are precursors to serotonin. That way you can replenish the lost Serotonin in your receptors from binging. Works for MDMA binges as well. Otherwise, you will crash since the laws of physics will apply. Anything that goes up, must come down. Therefore your body will feel the "comedown" since the serotonin receptors in your brain have been depleted from methamphetamine pushing out all its resevoirs through the synaptic cleft giving you that euphoria, energy and alertness associated with methamphetamine use. Talking from experience and a degree in O chem and neuroscience.

Some damage neurons can recover due to brain plasticity and some regeneration. But we have to talk about the insular cortex which is the brain addiciton center and how the hippocampus will modulate the reward center in the brains nuclues accumbens. Which is the reason for that insidious methamphetamine addiction since actual morphologic changes occur in a physiological level. Rewiring the brains neurons and causing dependence, tolerance and addiction. As in the picture shown, the brains serotonin receptors will downregulate due to the same plasticity after chronic methamphetamine administation.

mod note: please edit your previous post if you want to add something right after posting as opposed to posting again.