Misc How much Quercetin is safe to take at a time without causing kidney damage?

[Drag2019]

I was reading on that 1000mg or more daily can potentially damage the kidneys but I got a bottle of Now Brand Quercetin which is 400mg tablets which they tell you to take 2 capsules twice daily which I'm wondering if it may be a typo/imprint gone wrong or something cuz it used to only be 800mg a total of 2 capsules recommended daily.

Is it safe to take a high dose like 800mg at once too though?

 

[negrogesic]

Not sure, but I feel like i've seen quercetin sold in 1000mg per dose formulations.

I wouldn't be too worried. But many antioxidants can act as pro-oxidants at much higher doses. Personally I found quercetin to make me feel anxious. Not surprisingly since its a negative allosteric modulator of GABAA (but my GABAA system is shot).

 

[Drag2019]

Oh shit I asked this very question lol and my GABA system is shot too btw so I know I noticed an increase in anxiety when I first started using it but I've been using it for so long for various reasons I don't remember what it's like before I started taking quercetin daily.


Ironically I was about to make a post about my whether or not my daily low dose of benzos I've weaned down to is causing inter-dose withdrawal/rebound systems or not.

 

[negrogesic]

Yeah I'd definitely drop the quercetin completely if you are tapering benzos or have a fried GABA-A system from past benzo use.

Just take a gram/day of vitamin c if you want a decent enough antioxidant.

 

[Skorpio]

Honestly, flavonoid like quercetin are horribly non-bioavailable (quercetin has a reported bioavailability of less than 1% and a short half life).

Flavonoids tend to show some pretty impressive effects when applied to cells in a Petri dish, but once they contend with oxidative enzymes in the gut and the liver, there really isn’t much left to do anything for you aside from making expensive piss.

 

[Drag2019]

Well I already got a huge bottle left of it, how can I make sure it's causing me problems and that I don't need take a 3rd dose of my benzos I'm on 5mg nitrazepam in morning and 0.25mg clonazepam at night?

Oh and for the record 1 of the many reasons I use Quercetin is that it's supposedly a strong CYP3A4 inhibitor and P-Glyco Protein inhibitor thus potentially increasing absorption of medication and or supplements. But it seems any type of cyp3a4 inhibitor I've found has some type of negative side-effect that makes it so I can't use it frequently. Like for example certain antibiotics but they also will mess up the gut bacteria or w/e. I don't even like taking antibiotics for as long as Doctors recommend and I feel most times it aint necessary. BTW I'm just pointing this out as something I've noticed.

 

[Drag2019]

I read that Quercetin in food has a better absorption but I'm not so sure about that and I assume that any anxiety that a Quercetin supplement will cause is only for a few hours after taking a dose of it or am I wrong about that?


Also the supplement brand of Quercetin I take is mixed with Bromelain (found in pineapples) that supposedly helps increase the absorption and I take vitamin C with it which is supposed to help also. I know it can have as little as 1% can absorb but I've read it can be up to 17% also if I remember correctly and I think claims of food sources being able to be like 25-50% absorption rate and an onion which has the most from I'm aware of is like 100mg Querrcetin I think for an average onion.

 

[Drag2019]

Does anyone know if cooking food destroys any of the Quercetin at all? I always eat my onions fried and never raw as I don't like the "spicy" feel it has when raw but I was wondering if that matters regarding the Quercetin amount in it?