I've been using methadone most days of the week last week, today is my first day with none of it in my system (didn't take any yesterday but woke up somewhat high still) and I feel like SHIT. drank a little last night, but not enough for this to be a hangover. pounding headache, nausea, and my sinuses feel off. threw up yesterday morning too. was wondering if this illness is withdrawl or something else
Similar thing happened to me the first time i ate a 80MG OC oxy cut in half almost completely naïve to all but codeiene at the time, had a 10mg slow oxy maybe a hand full of times before. Woke up still high with a headache after a nod and a full sleep so yeah, your certainly going through something that a lot of us have gone through before, as for withdrawals the prior posts are technically correct, you are not going to be in withdrawal, however methadone is one hell of a hook and everyone's is different as to when or what dose will put them over the limit, this of course comes down to how long you have used, your current health and how you react to these things during and post experience. Drinking is never going to help seeing as methadone in your system especially if your not us to it is going to feel more toxic than say an equivalent MME of most other opioids.
Also very important notes to keep in mind, after 3 days of continual usage of any agent (methadone's half life being so long for stabilisation in use and less dosage ideally) *although many on the programs will disagree*, more on this at the end. I have also read many times over but not research enough to say with 100% certainly this is how it works however; note that methadone during its initial use stages are said to be closer to the strength of morphine but with build up in your system quickly can climb to 6-11x the strength of morphine, even if you have not felt like its climbed in strength there is a good chance your body and system is now us to a ever so slight build up and its POTENTIALLY POSSIBLE, you're experiencing the very tickling's of what a withdrawal can feel like, on methadone and Bupe, aka agonist/antagonist opioids medications are said to be and ime harder to reverse the OD of should you go to far, but more importantly to your current situation can throw you into precipitated withdrawal should any of the opiates your getting not really be methadone and there's very little chance you'd be able to tell without prior and vast experience of these opioids and having used them.
As for the continuation of the people disagreeing with these essentially scientifically based conversions, few take into account the idea that just because 1 drug gets you more fucked up or feeling better, stronger, etc, has little to no affect on pharmacological interactions and bio activity within the user. Heroin for example is heavily disputed as being up to 6x stronger than morphine pharmaceutically yet, at least as far as the NIH is concerned "Heroin hydrochloride is
approximately twice as potent as morphine sulfate, and acts slightly faster but for a shorter duration than morphine." Now many reasons this has been disputed, from users getting stepped on or cut to shit product and or stronger laced opioids as are only ever more common these days, or perhaps they think heroin was what gave them their first drug love experience, be it another drug they had or actually heroin to any level of purity, most users of any drug ime have a period of nothing ever again touching close to the original experience you fell in love with.
More info if you care to read on:
As to how you administer the substance of course will make a huge difference as for example heroin's oral bioavailability is horrible and IIRC. The reason heroin was able to be sold as a weaker less addictive alternative to morphine when first discovered, was I believe since oral usage does show heroin to give less pharmacological activity on the receptors for a shorter period of time and less affinity for when orally consumed, at least based on the times research and evidence (not saying it was all above board and honest) but yet there is as i will cite below as a reference, research showing today that oral consumption of may still yield higher morphine uptake and conversion in the body, than regular morphine. For a final and related but different drug class example would be, Ativan otherwise known as Lorazepam. *a benzodiazepine is equipotent to Xanax, Aka Alprazolam. Now with benzos there is in a sense more to take into account, while pain reliving opiates can run their magic through different opioid receptor channels and so fourth such as the Mor, Dor, Kor, and NOP receptors (Mu, Delta, Kappa and Nociceptin, Opioid Receptors, your methadone for example is primarily a MOR opioid Agonist, and tramadol/tapentadol like drugs work on nerve pain to a degree and serotonin in the case of tramadol where a classic opioid does not provide this. Back to the benzos, Lorazepam 1-1 for Alprazolam for anxiolytic effects however you would gain greater anti convulsive effects from the lorazepam more so than even diazepam IIRC, the gold standard for such benzos go to if not temazepam for sleep, the good old Diazepam or Valium. To further complicate this, temazepam turns into oxazepam at least if my research and memory serve me here, the as they say "day" version of temazepam as iv heard some doctors refer to it. Just another example of how complicated this all can really get when you play with these level of drugs. (This may be edited later for correction, or errors this was posted in slight haste while i finish up my work night.
Reference:
Edited: Removed Methadone as a Partial Agonist/Antagonist
Noted from Senor Moreno: Methadone is more potent than morphine even in the initial exposure period.
(As far as i could research about 5mg of methadone at first is equipotent to around 7.5mg morphine, while quoting its relative potency to be 5-10 times that of morphine.)
Reference to above edit:
https://www.ncbi.nlm.nih.gov/books/...A single 5 mg dose,than the range given above.
