Oh yeah, bring back that para-methylated serotonin goodness! It's a shame that 4,4'-DMAR had to take such a death toll just because of reckless capitalist vendors. This stuff was indeed amazing! At 25-50mg I was like 10 days constantly rolling, even when each one was slightly less intense than the before, I guess with MDMA that's unthinkable. Never ever had a full traditional roll yet so can't compare really, but my experiences from 4,4'-DMAR (very clear headed) and 4-MMC (pretty trippy and somewhat dirty at higher doses, enjoyable at lower ones though) come pretty close to what I'd expect from MDMA, just staying somewhere in the middle in terms of clearness.
It's something which I plan to catch up on in future but I fear a bit that prolonged venlafaxine (+ low dose DXM for quite some time when summed up) use might have left me with a permanently altered serotonin system. Also my hunch is that SSRIs underlie the same tolerance and receptor downregulation rules as all drugs and thus people being new on a SSRI with most of their transporter blocked won't feel much of a roll but maybe more of headache (but that's a strange one; e.g. paroxetine gives me bad headaches while venlafaxine and fluoxetine don't. A doc told me it was because of the potency and that 'too much serotonin' caused headache but well then why doesn't MDMA induce such, also with reuptake inhibitors the net increase in serotonin is limited due to autoreceptors; so maybe that doc didn't know everything, as usual.
Well and then as months pass and the brain re-regulates, there will eventually be more free SERT to be inversed by MDMA. Correct me if I'm wrong, somehow I have the lingering memory that once somebody here told me that the theory of inversed transporters about releasers was outdated, but maybe that only applies to amphetamine being a TAAR agonist. At least methylphenidate and cocaine have been shown to actually inverse agonize the DAT, and probably also SERT for cocaine.
Some chem I was always curious about is 4-MAR. Must be a cross between 4,4'-DMAR and meth; some rare experience reports make a good impression, never ever read anything bad about it other than the long duration which DMAR shared (I could sleep well on it though, it had a pretty sudden comedown after maybe 9-10h which sometimes brought me tears for some minutes but then it was over. Redosing a tiny amount also helped.) With DMAR it's remarkable that we have a SNDRA and MAO-A inhibitor packed into one single molecule, what sounds like serotonin syndrome and hypertension is actually pretty good, guess it must be either a low strength MAOI and/or a reversible one. A cautious experiment involving moclobemide and a tiny amount of amphetamine heavily increased my blood pressure and felt just tensious, no euphoria or focus at all, but that might be explainable by low-threshold dose amph being selectively norepinephrinergic and DMAR was more balanced, I'd say 5-HT < DA < NE and MAO-A inhibition. Might be completely wrong though.
Yeah, psychedelics on SSRI won't cause harm unless one is heavily predisposed to serotonin syndrome, I myself combined recklessly and know of others who also got no or only mild symptoms. It can become uncomfortable though, I remember me redosing shrooms when I was put freshly on a SSRI and thought they were bunk because of no effects. Ended up with heavy speediness and scattered thoughts, but also at that time I knew little about drugs and that psychedelics can't kill or maybe even harm you as long as it's not synthetic 5ht2a full agonists. Serotonin toxicity is not to joke though and always better to be safe than sorry. They should give cyproheptadine (seems to be the serotonin antagonist of choice) nasal spray to psychonauts in the same fashion as people can get naloxone kits.
