no just wds, take it when you feel like complete and total shit, ive made the mistake of thinking ok im sick enough and being sick, runny nose, rls, cravings, ect ect and take a bupe and i would precipitate the WDand have it get wrose before it got better. yea id say 48 to like 50 hoursand it doesnt really matter how much of the bupe you take, even a little will precipitate WD its so strong.