my exp and routine is to use ~25-30mg, as anything more doesn't seem to do anything more, and generally a dose is good for 3-4 hours. i'm ~5'9" and 140lb with a fairly high metabolism and tolerance having used opiates daily for the last 6-7 years and occasionally before (I was in a bad car wreck). Hydrocodone is a great painkiller and mood lifter but not a "hard" opiate IMHO. But a friend can't take 10mg without getting sick (no tolerance at all) and he'd be sick all night. a big guy too. IMHO its great if its all you got but ideally I'd use it to potentiate something else. Like taking 10mg with a usual pod tea dose greatly augments it. My doc told me a couple advil also potentiates it greatly (and always writes an 800mg ibuprofen with any hydrocodone/APAP)