Hello guys, this Is me again.
Some of u probaly remember the thread about Buprenorphine being not only opioid...this thread switched into exchange of personal ideas some of them more legit than others...about H1 ANTAGONISTS, being gaga-ergic or somohew related to our CNS "breaks" system, baised on (but not ONLY) on gaba.
I realised, one thing and i do not want to downgrade or humulliate anybody but i found out on personal research as an epileptic pacient, opioid and benzo addict, in connection with psychiatrists, neurologists, algeziologistst...basicly, those is it and it Is definitive :
1. Opioid, opiates, partial mu - agonists, all of them lower your gaba levels (said simple so everybody can understand)
1,a.
Tramadol, oxycodone, tapentadol, buprenorphine,and basically everything almost every opioid do the opposite of things that benzodiazepines do. They all make our seizure treshold low.
(I wasn't seraching about fentanyl and Its derivatives). Most safe in this sense, Is good old morphine, heroin, hydromorphone, dihydrocodeine, hydrocodone and maybe even codeine. ( this does not mean they are the most fun, just most chill out opiates / opioids which lower seizure treshold too but much less than buprenorphine, tapentadol, tramadol, oxycodone and less casual ones (for example lovorphan ).
I have experienced seizures from opioids, opiates if i took them without antiepileptic medication and/or benzodiazepines.
2. Modafinil Is histamine agonist. But research resulted in surpsing anticonvulsant properties.
3. H1 ANTAGONISTS, from high dose cetirizine, normal and high dose diphenhydramine and many potent antipsychotic medications ( quetiapine, chlorprothexine etc) , they lower seizure treshold. But if u take something against seizures (seizure prevention) they are great sedatives for as needed use. Less , better said much lesa addictive than benzodiazepines which i can't even feel properly after years on them. But without them, i won't seize on other meds for epilepsy but i will be edgy and sleep-deprived ( for sleep pregabalin Is much better but be careful, high doses can trigger seizures.).
That's it. Feel free to ask or add anything, nobody would be bullied or somohew downgraded. But this Is really, fact.
Maybe one more thing to say, if u use and i hlave to use benzos, it also lowers analgetic effects of my opioids.
This theme Is quite complicated and user experiences and new research, supply us with new information but this Is some basic information, which can be useful or appreciated.
Thanks and have a nice day.
Some of u probaly remember the thread about Buprenorphine being not only opioid...this thread switched into exchange of personal ideas some of them more legit than others...about H1 ANTAGONISTS, being gaga-ergic or somohew related to our CNS "breaks" system, baised on (but not ONLY) on gaba.
I realised, one thing and i do not want to downgrade or humulliate anybody but i found out on personal research as an epileptic pacient, opioid and benzo addict, in connection with psychiatrists, neurologists, algeziologistst...basicly, those is it and it Is definitive :
1. Opioid, opiates, partial mu - agonists, all of them lower your gaba levels (said simple so everybody can understand)
1,a.
Tramadol, oxycodone, tapentadol, buprenorphine,and basically everything almost every opioid do the opposite of things that benzodiazepines do. They all make our seizure treshold low.
(I wasn't seraching about fentanyl and Its derivatives). Most safe in this sense, Is good old morphine, heroin, hydromorphone, dihydrocodeine, hydrocodone and maybe even codeine. ( this does not mean they are the most fun, just most chill out opiates / opioids which lower seizure treshold too but much less than buprenorphine, tapentadol, tramadol, oxycodone and less casual ones (for example lovorphan ).
I have experienced seizures from opioids, opiates if i took them without antiepileptic medication and/or benzodiazepines.
2. Modafinil Is histamine agonist. But research resulted in surpsing anticonvulsant properties.
3. H1 ANTAGONISTS, from high dose cetirizine, normal and high dose diphenhydramine and many potent antipsychotic medications ( quetiapine, chlorprothexine etc) , they lower seizure treshold. But if u take something against seizures (seizure prevention) they are great sedatives for as needed use. Less , better said much lesa addictive than benzodiazepines which i can't even feel properly after years on them. But without them, i won't seize on other meds for epilepsy but i will be edgy and sleep-deprived ( for sleep pregabalin Is much better but be careful, high doses can trigger seizures.).
That's it. Feel free to ask or add anything, nobody would be bullied or somohew downgraded. But this Is really, fact.
Maybe one more thing to say, if u use and i hlave to use benzos, it also lowers analgetic effects of my opioids.
This theme Is quite complicated and user experiences and new research, supply us with new information but this Is some basic information, which can be useful or appreciated.
Thanks and have a nice day.
