Naltrexone does reduce the cravings for alcohol - but doesn't have a direct effect on alcohol itself, so you will
still get just as drunk.
The only way to get less drunk is to drink less, and to reduce the hangover, the best things to drink are either
'neutral spirits' (Vodka rather then Whisky or Brandy), or to drink beer... Red wine is one of the worst things.
This is probably as Vodka has very few hangover-causing impurities, but is so concentrated you can get
easily dehydrated, whereas beer / lager has impurities / hangover-causing molecules in it, but it is so dilute
that the dehydration is much less than spirits. The best / least hangover-causing way is to drink Vodka mixed
with fruit juice or whatever, and then drink lots of water before going to sleep.
In the longer term, liver damage is a major concern. However, look up acute and chronic pancreatitis... this
makes liver disease look like a walk in the park in some ways. Another major problem with alcohol is
nerve damage - this can occur as the direct toxic / poisonous effect of alcohol (causing problems such as...
Alcoholic Neuropathy - loss of sensation to distant parts - usually toes and fingers, slowly travelling up the
legs; this is combined with problems with blood supply caused by other autonomic nerve damage, so your
toes etc can become deprived of blood, and painless, so become easily damaged, and can lead to
amputations.
Cerebellar damage - this is the balance organ in the brain, and can stop you walking properly, and make you
fall over all the time.
Alcoholic Dementia - this is when the alcohol literally kills cells in the brain and eventually you get an early,
incurabale dementia.
Wernicke's Encephalopathy - this is a very scary, but importantly a
TREATABLE problem. If you drink very large
amounts of alcohol, you tend to eat less food... so you get less vitamins. Thiamine is a nutrient in food that is
very important in processing sugar in your body to turn it into useable energy. In chronic alcoholism, you eat
less food, so have less Thiamine, and also your digestive system changes so that you absorb MUCH less thiamine
than usual (so even if you take thiamine tablets, most of it passes through without being absorbed).
If a chronic alcoholic does a detox suddenly, and reduces alcohol intake (hopefully taking Diazepam under prescription
from a Dr), then they will start eating more food. Your body (and especially brain) will have started running
on Alcohol rather than Sugar (literally)... The sugar goes to the brain, and it breaks down into a toxic acidic substance.
This is then broken down using THIAMINE to a harmless substance... as the Thiamine is deficient in chronic alcoholism,
instead the acidic substance builds up everywhere... in Wernicke's area of the brain, the cells are very sensitive, and
can be easily killed by this. The end result is something called 'Korsakoffs Psychosis' - which isn't psychosis, but is
a syndrome where you have NO ability to lay down memory any more. You can remember for the past 30 seconds,
and remember your life story up until the time you have *untreated* Wernicke's encephalopathy, but after that point,
you can never lay down any new memories. This is obviously completely disabling, and is incurable. To avoid this,
alcohol detoxification should always be under medical supervision, and with Thiamine given (via injections of some kind)
since it takes approx 6 weeks for digestive system to begin to re-absorb Thiamine properly - which is too late if you
are only taking Thiamine tablets!
A final comment - taking stimulants (speed, cocaine, etc) with Alcohol allows you to get more drunk and can stop
*some* of the 'drunk' effects (not all due to the fact that, as noted above, Alcohol is 'dirty' in that it has effects all
over the brain). Taking stimulants to drink more alcohol is a very dangerous thing to do though. You can easily become
lethally drunk, and then go to sleep... the stimulants wear off more quickly, and you end up going into a coma, and
(for example) inhaling your own vomit, or just stopping breathing. A friend of mine, who was a medical doctor, died
due to this - the stimulant was caffeine (about 20 cans of coca cola per day at least) and a single night of heavy drinking;
no other medications but he never woke up. He was about 25 at the time, and was just completing his second year working
as a doctor (was very caring, and very good in his medical care, especially emergency situations)
