Opioids Help w/ PWD High dose lope to Subs

[beautyitalian27]

I've been on Subutex for about 13 years. Every once in a while I go on high dose lope to get me through until my next appointment due to being on the wrong dose. I have gone through horrifying PWD countless times going from high dose lope to my subs. If tried Burmese method, I've tried taper, I've tried going on a shorter acting opiate for a few days between, etc. No matter what I've tried I've always had to go through the most insanely painful PWD's for about 2 days then about 3-4 more days with some physical withdrawal and mental. I just need some advice to ease some of the physical and mental to get me through at least the first 2 days. I've got some passion flower extract to help with some of the mental, 3 tramadol left over from tooth extraction, and tons of 100mg gabapentin. I've tried the gabapentin and it leaves me with horrible cotton mouth and this really awful taste but a little bit of relief. Any advice to help. I'm jumping from 92 pills a day. I was wondering if possibly doing about .15 sub and 12-16 lopes might make it tolerable. Any advice will be helpful.

 

[Jen X]

Are you trying the bermese method again? It worked for me when I got off methadone and fentanyl. Just go slowly. I started with 0.5mg subs and went up every second day and when I reached 4mg of subs I stopped methadone and fentanyl(I wasn't doing much fentanyl though and my methadone dose was around 40-60 )

Maybe taper a bit more before trying the method. I don't know about loperamide but it may be something that if tapered a little would make the transition easier.

 

[Jen X]

92 2mg pills a day is high and it has a long half life.
A doctor told me for taper do 10% drops until you reach 1/3rd of your habit then drop by 5%. But do what feels best for you

With the long half life I would taper once a week.

 

[beautyitalian27]

Yeah, I started at 60 pills and slowly went up because w/ lope your body quickly builds up tolerance. I don't have time to do the Burmese method again. I just have to jump off. Usually when I jump off I start with about a .25 MG dose of sub and it's still really bad. Problem with lope is that it's lipid soluble like fent. That's why the PWD are so very drawn out. I got California poppy extract and passion flower extract which are both good GABA stimulants. I'm just looking to ease a bit of the horror I go through for 2 days. I've never really found anything that helps. Thanks for the response. It's much appreciated

 

[fairnymph]

Have you tried the basics like diphenhydramine, chlorpheniramine, pseudoephedrine, clonidine and benzos, ideally diazepam? These can help make withdrawal symptoms more tolerable, but it would help to know which ones you’re struggling with the most. For example, I find the aching legs to be the worst effect and diazepam helps with that the most. Gabapentin seems very helpful for the restless legs. Pseudoephedrine is great for drying my nose out and reducing the urge to pee so badly. Chlorpheniramine helps with the running eyes. Taking baths with a few pounds of Epsom salts or magnesium chloride makes me feel a lot better too. I haven’t use clonidine myself because I have borderline low blood pressure but many find it good at reducing multiple withdrawal symptoms.

 

[beautyitalian27]

So, by far the tension of my muscles and the body temperature fluctuations are far and away the worst part for me. I have tried some of the basics. I've gone through the lope PWD's about 5 times in the 13 years I've been "sober". I'm hyping myself up for tomorrow and anticipating the worse possible scenario. Reaching out to ppl who understand definitely feels comforting to me. I think it's just all about prepping my brain to think that the first 2 days are the worse and I just need to get through it. I really appreciate the suggestions. I can't take clonidine due to a stroke I had giving birth and deep vein thrombosis of the brain after my stroke. I wish those were options for me. I've never actually been able to try them. Thanks again so much!

 

[fairnymph]

So, by far the tension of my muscles and the body temperature fluctuations are far and away the worst part for me. I have tried some of the basics. I've gone through the lope PWD's about 5 times in the 13 years I've been "sober". I'm hyping myself up for tomorrow and anticipating the worse possible scenario. Reaching out to ppl who understand definitely feels comforting to me. I think it's just all about prepping my brain to think that the first 2 days are the worse and I just need to get through it. I really appreciate the suggestions. I can't take clonidine due to a stroke I had giving birth and deep vein thrombosis of the brain after my stroke. I wish those were options for me. I've never actually been able to try them. Thanks again so much!

Diazepam would definitely be your best bet then, but if you can’t get that I would stick with the gabapentin if you can tolerate it because I do find it helps somewhat, and you noted that yourself. But how is it leaving a bad taste in your mouth since it comes in capsules usually? Definitely try the Epsom salt/magnesium chloride bath. I haven’t found anything better for the symptoms that you find most intolerable. Magnesium (Epsom salt is simply magnesium sulphate so you’ll get plenty of magnesium in your system either way) is really fantastic for muscle tension.

You should also make sure you’re getting plenty of electrolytes. Trace Minerals makes a product ConcenTrace which makes water much more hydrating helps with muscle cramping and headache headaches and makes water taste delicious too. You could also make your own electrolyte solution out of magnesium chloride, table salt - I recommended pink Himalayan salt, and potassium citrate in a 6:2:1 ratio. But be very careful about adding it to your water because it will make your stools softer. When going through withdrawal, it’s better to just use salt and potassium in your water and get your magnesium topically from frequent baths.

I have to go through withdrawal a several times a year to keep my tolerance down so you have my sympathies! It sucks, but you will get through it! I find distracting myself with music and media works quite well. Oh, and ketamine can be super useful, although you’ll need to redose frequently. Make a concentrated solution of 2g/ml and start with 20 units. Put the liquid under your tongue and hold it there for at least five minutes, up to 20 minutes if you can. Being able to shut down sensation in your body for a brief time can be very relieving.

 

[HealingEnergy14]

What helps me get through withdrawal the most is Phenobarbital or Zolpidem to calmdown and sleep (a bit), then deschloroketamine to zone out/dissociate somewhat and be able to engage with a TV show or movie.

Like fairnymph suggested, magnesium baths are also very good. You can relax (somewhat...) atleast for 30mins.

 

[helpingout]

Dude

Are you trying to die?

Loperamide is so fucking dangerous. So totally fucking dangerous.

Your electrolytes are probably completely fucked.

Stop taking lope.

Try calculating the half-life elimination period for your lope dosage. I remember when I was fucking around with that shit I wouldn’t feel withdrawals for eight days. I can calculate it for you. Ok I will

For 92 pills a day 184 mg assuming an 18hour half life you’ll need to abstain from loperamide for 12 days before your plasma concentration will dip below sub milligram levels.

You can’t take any loperamide for 8-12 days without going into pwd id bet.

do your Bernese and get off that shit

Once your off please start eating 10 bananas a day or at least like three bananas and a medium potato.

Your potassium levels are going to be so fucked up.

So many cardiac conditions evolve from
An imbalance of sodium and potassium.

You’re going to need to see a doctor and get your blood checked for your electrolyte levels and I’d bet that you’re going to need medical intervention to correct them.

Please don’t just scroll by my comment.

Take me serious.

I hold your wellbeing in high regard.

 

[Jen X]

Can you get clonidine?? That's my favorite detox drug. Calms the skin crawling and helps with anxiety

 

[beautyitalian27]

Dude

Are you trying to die?

Loperamide is so fucking dangerous. So totally fucking dangerous.

Your electrolytes are probably completely fucked.

Stop taking lope.

Try calculating the half-life elimination period for your lope dosage. I remember when I was fucking around with that shit I wouldn’t feel withdrawals for eight days. I can calculate it for you. Ok I will

For 92 pills a day 184 mg assuming an 18hour half life you’ll need to abstain from loperamide for 12 days before your plasma concentration will dip below sub milligram levels.

You can’t take any loperamide for 8-12 days without going into pwd id bet.

do your Bernese and get off that shit

Once your off please start eating 10 bananas a day or at least like three bananas and a medium potato.

Your potassium levels are going to be so fucked up.

So many cardiac conditions evolve from
An imbalance of sodium and potassium.

You’re going to need to see a doctor and get your blood checked for your electrolyte levels and I’d bet that you’re going to need medical intervention to correct them.

Please don’t just scroll by my comment.

Take me serious.

I hold your wellbeing in high regard.

I've never claimed that what I was doing was good, healthy, nor the best option. I know the risks involved. My actual intake doesn't come close to the amount people are taking to actually get high off it. Most ppl are on 200 plus pills a day. First I only just upped to 92 pills. You build a tolerance very quickly on these. I've only been on the 92 for about 3 days. I started at 56 pills. None of this makes it good or safer. I went to my doctor and they oked the clonidine. My precipitated withdrawals usually last about 6 days with the first day being the most unbearable. I feel withdrawals right away with these so, saying it'll take 12 days to feel anything isn't exactly accurate for me. Everyone is different and one of the biggest reasons I run out of meds every once in a blue moon is because I metabolize medicine at a very high rate. I'm jumping off tomorrow with just the clonidine and getting myself out of this nightmare. Hopefully the Precipitated withdrawals are bearable with the clonidine and if not I can only blame myself. I won't look back though.

 

[Smyth2]

I found a supplier who was offering 1000 x loperamide 2mg for £34.16.

I was going to ask is 10 tablets is a good starting dosage but you are stating an amount far in excess of this.

I read that loperamide works best when it is combined with cimetidine or any other cytochrome P450 inhibitor such as grapefruit juice.

I might be able to get fresh grapefruits at the local market stall but the nearest place to buy grapefruit juice you have to take a bus or drive.

 

[Smyth2]

Fluperamide and loperamide are structurally related compounds, both acting as opioid receptor agonists. However, their ability to cross the blood-brain barrier (BBB) differs significantly due to their interaction with P-glycoprotein (P-gp), an efflux transporter that limits drug penetration into the brain.

Loperamide is a substrate for P-gp, which actively pumps it out of the brain, preventing central nervous system (CNS) effects. This is why loperamide, despite being an opioid, is used as an anti-diarrheal without causing typical opioid-related CNS effects.

Fluperamide, on the other hand, is less efficiently excluded by P-gp, allowing it to cross the BBB more readily. This difference in permeability makes fluperamide more likely to exert CNS effects compared to loperamide3.

 

[daturetard]

Can you get clonidine?? That's my favorite detox drug. Calms the skin crawling and helps with anxiety

What type of dose you take? I've got these weak Indian 100 mcg and even 2 barely does anything unless I'm on a bunch of stronger shit like opiates, what i mean is: it's only good for a potentiator imo. Mine might just be shit though cause they're in a blister pack that says "arkamin" or something but the pills are unmarked...

 

[daturetard]

I found a supplier who was offering 1000 x loperamide 2mg for £34.16.

I was going to ask is 10 tablets is a good starting dosage but you are stating an amount far in excess of this.

I read that loperamide works best when it is combined with cimetidine or any other cytochrome P450 inhibitor such as grapefruit juice.

I might be able to get fresh grapefruits at the local market stall but the nearest place to buy grapefruit juice you have to take a bus or drive.

You were planning to take them to get high? How did it workout?

 

[Smyth2]

i get shits from when i take orlistat capsules but i've cut down on it now i have lost most of the weight i need to.

I was reading into some of the posters on this site and it seems like a bad idea to take them to get high because of the cardiotoxicity.

Although the 1000 tablets arrived on Friday I have only taken 2 of them so far.

 

[Jen X]

What type of dose you take? I've got these weak Indian 100 mcg and even 2 barely does anything unless I'm on a bunch of stronger shit like opiates, what i mean is: it's only good for a potentiator imo. Mine might just be shit though cause they're in a blister pack that says "arkamin" or something but the pills are unmarked...

I usually took 2-3 but they came from a pharmacy

 

[Quasimoto]

My actual intake doesn't come close to the amount people are taking to actually get high off it.

Cardiotoxicity starts as low as 60mg, or 30 pills, and deaths have been reported in medical literature at this amount. Be careful not to lull yourself into a false sense of safety just because you don't use as much as others.

 

[Jen X]

I found a supplier who was offering 1000 x loperamide 2mg for £34.16.

I was going to ask is 10 tablets is a good starting dosage but you are stating an amount far in excess of this.

I read that loperamide works best when it is combined with cimetidine or any other cytochrome P450 inhibitor such as grapefruit juice.

I might be able to get fresh grapefruits at the local market stall but the nearest place to buy grapefruit juice you have to take a bus or drive.

Why are you taking such a high dose?

 

[Smyth2]

I remember talking to a bl poster on irc ages ago called thetripdoctor.

Search results for query: loperamide

www.bluelight.org

He was explaining at the time how they sell 1000 count bottles of loperamide on amazon and he had taken them to get high.

The chemical structure is similar to desmethylmoramide. I've never tried a high dose of loperamide personally.