friend took 6 10/650's thinking they were 6 325's. I have a bunch of oral acetylcysteine and he is about a 15min drive. he just called me and took the pills about 15-20min ago. I am going to rush over there. I know he isn't gonna die of have perm liver damage but he is scared and it will calm him down. can anyone give me/him a time frame for oral NAC for liver protection properties? I will check this thread when I get there. THANK YOU BL!
Opioids HELP! oral NAC after 4g apap.
- Thread starter jeah
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sekio
Bluelight Crew
4 grams of APAP is not something you need to worry about, unless you're doing it on the regular. The FDA limit actually used to be higher, it's really a worst-case-scenario minimum limit.
NAC, anecdotally, tastes like shit and can upset the stomach, so ironically it may not be a good idea to pump your friend full of NAC unless he has acute symptoms that clearly suggest liver failure/APAP overdose (10+ gms ingested, painful stomach cramps, pallor, unremittant nausea, jaundice).
Though for reference: the time frame for NAC for apap poisoning is: the sooner the better. Within hours of ingestion is ideal, after 24 hours you are probably wasting your time.
But again, like I said, 4 gms of APAP is not a toxic dose in about 98% of the population, & there is not really a need to panic unless there is clear evidence that your friend is in trouble.
Just tell your friend to calm down and drink a glass of milk or something. Unless he is a chronic daily alcoholic or takes multigram doses of APAP every day, there will likely be no long term or acute effects.
NAC, anecdotally, tastes like shit and can upset the stomach, so ironically it may not be a good idea to pump your friend full of NAC unless he has acute symptoms that clearly suggest liver failure/APAP overdose (10+ gms ingested, painful stomach cramps, pallor, unremittant nausea, jaundice).
Though for reference: the time frame for NAC for apap poisoning is: the sooner the better. Within hours of ingestion is ideal, after 24 hours you are probably wasting your time.
But again, like I said, 4 gms of APAP is not a toxic dose in about 98% of the population, & there is not really a need to panic unless there is clear evidence that your friend is in trouble.
Just tell your friend to calm down and drink a glass of milk or something. Unless he is a chronic daily alcoholic or takes multigram doses of APAP every day, there will likely be no long term or acute effects.
update. dude is more of an acquaintance. he freaked out, didnt pill ID. he still had 4. they are just norcos but white. m367. i gave him 1200mg NAC and he wants to know (hell, me too) if it will affect the high? im gonna just leave i thought he was in decent danger. any help/advice etc about NAC, if it effects an opiate high and does it actually work orally? thanks guys, you can take the HELP out of the title.
edit: thank you Seiko, have always appreciated your knowledge. so he just took 1950mg. but I did give him two 600mg NAC's.
does it do anything to lessen the opiate high? also, hypothetically, if you took 10g apap then had a hospital administer IV NAC would it prevent liver damage? what about 40g APAP. have always been curious about NAC and tend to take it after EVERY 1.5g-2.5g Tylenol dosage. is this safe? stupid? any harm in this? I'm just very curious about acetylcysteine. thank you.
edit: thank you Seiko, have always appreciated your knowledge. so he just took 1950mg. but I did give him two 600mg NAC's.
does it do anything to lessen the opiate high? also, hypothetically, if you took 10g apap then had a hospital administer IV NAC would it prevent liver damage? what about 40g APAP. have always been curious about NAC and tend to take it after EVERY 1.5g-2.5g Tylenol dosage. is this safe? stupid? any harm in this? I'm just very curious about acetylcysteine. thank you.
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sekio
Bluelight Crew
No, it shouldn't
Depending on dose and how quickly you had it administered, sure. If you got to a doc within an hour or so I think you could probably survive 100 gms... but there'd be activated charcoal involved too
Honestly, if you eat any sort of healthy balanced diet, you don't need to take NAC after APAP... With a BA of 6-10% orally you are not going to do anything worthwhile. Oral dosing would work, but you need humongous quantities, hence why it'as admin IV and why it upsets the stomach orally. (imagine eating 50 grams of bitter nasty taskting alkaloid)
brutus
Bluelight Crew
I'm going to close this since sekio nailed it.
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