I've found a link with Toll Like Receptors that creates the chemicals that in turn are causing your chronic fatigue symptoms. These chemicals called proinflammatory cytokines have an affinity for your opioid receptors. Most people think you only have opioid receptors in your brain (mu and ku) well
actually they are found throughout the body.
Drugs like Naltrexone also have a higher affinity for these receptors then the cytokines thus causing relief (among a host of other things) by blocking these chemicals from binding to the opioid receptors throughout your body..
However these are all just band-aids. Wouldn't it be better if you simply stopped your body from making these cytokines. But wait a minute don't we need these cytokines? What are they for you ask? Well they're used to fight infections. White blood cells signal the Toll Like Receptors when they find bacteria and such in your body. Whilst its also been found that stress hormones can also activate the Toll Like Receptors, especially in individuals primed from birth. Which is someone like you. Your next question is something like, how on earth did you get primed at birth.
Well when you were a fetus and soon after you were born, whilst your brain was still goo, forming, and your mother was subjected to stressful situations like your dad beating the shit out of her, or running out of money/living in poverty, or being abused or bullied, or just yelled at she produced stress hormones. I haven't found research yet that explains how but they've found that stress hormones change certain structures in the brain like the glia.
My thesis is that stress hormones prime your brain into thinking its constantly under attack. It doesn't understand these attacks aren't bacterial but fires off primitive functions that are no longer necessary, that flood the body with toxic chemicals that are essentially are scorched earth policy the body has i.e. it would rather burn and destroy the tissue before letting the bacteria take it over and use it to replicate.
So your body is full of these chronic fatigue causing chemicals. Obvious the levels will vary at different levels (and there are like a dozen of these different cytokines), and they break down of course. They also cause a host of different reactions in different individuals which is entirely dependent on the level of stress they were and are subjected to. The key thing to understand is that these cytokines are responsible for a fuck ton of problems
- anxiety
- depression
- fever
- tissue damage
- joint pain
- nausea, vomiting
- diarrhea
- fatigue
So with that understanding anti-depressants, anti-inflammatories, and even painkillers like opiates are ultimately band-aids. Worse there is clear research that suggests anything that makes it through the blood brain barrier that the brain thinks is "foreign" can trigger inflammation responses courtesy of TLR4. Hence why most drugs cause "withdrawals" (hang on a little bit longer and you can understand why i put that word in ""). And some of those substances I described like o
piates such as morphine and heroin actually have metabolites that activate the Toll Like Receptors (TLR) directly hence why after chronic heroin use the cytokines have built up (hence tolerance) and the moment your heroin wears off your body is flooded with these toxic chemicals that love nothing else then binding to your opioid receptors all over your body.
A maelstrom of symptoms that we call "withdrawals"
So the obvious solution. Stop the TLR from activating, specifically TLR4.
There is a drug called ibudilast and the reddit forums on nootropics forum that can teach you more. The reports on people using ibudilast is impressive. I love how the medical world are so quiet on this drug when is the the mother of all anti-inflammatory agents seeing it stops inflammation cytokines from being made full stop. Technically if it was made available (and its incredibly safe) you would destroy the paracetamol, ibuprofen and black market drug trade in opiates, amphetamines and legal drug markets like alcohol because basically it cures addiction. It would end the war on drugs. It would end the trillion plus spent on cops, prisons and judges across the planet in the most useless conflict ever devised by man. It would stop destroy big pharma as they
peddle useless anti-depressants that try to treat depression and anxiety that are directly caused by things like TNF-A (a cytokine).
It would destroy the black market in drugs because no one would need a gram a day addictions. You wouldn't be addicted to met. Whilst the big brewers would collapse as the scale of economies would no longer stack up as alcoholic stop their their litre a day addictions.
And the god damn fucking drug addiction treatment sector. The biggest peddlers of false hope would be utterly destroyed. 12 fucking steps, private clinics, Ultrarapid Opiate Detox "cures" and so on.
See when your on a break from your addictions and you've been clean for a few months and your getting waves of anxiety, depression, aches and pains, fatigue and all the rest of it, and your thinking its PAWS (Post-acute-withdrawal syndrome) and all you want to do is slide a needle into your arm, a slug a whisky into you stomach, or smoke your meth pipe you have to understand that your environment, plus the fact your a sensitive/primed from birth individual, is causing your TLR4 to activate and in turn pumping you with these fucking asshole cytokines.
Hence why ibudilast will stop that shit from ever building up. Will stop you from feeling sick in the first place. Will get rid of the PAWS and stop people from relapsing.
