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Alcohol Help me get more drunk

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Biovail

Biovail

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Getting really drunk without drinking much

Hey guys,

so I'm not usually a heavy drinker, simply because of how bad it is for you. Tonight though, I want to get plastered. In the interest of harm-reduction, I'd like to get as drunk as possible while consuming as little alcohol as possible (since the metabolites of alcohol are even more damaging than the alcohol itself). Is there anything I can eat, drink, or otherwise consume that will potentiate the effect of alcohol over the course of the night?
 
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There is one obvious answer, but since this is a harm reduction forum, I'm not sure if the mods would be happy with me posting a potentially lethal combo.


Otherwise, don't eat anything before/during drinking.
 
^I assume he is talking about taking some other drugs with the alcohol, which is not potentiating the effects of alcohol and for the interest of HR is very dangerous, especially with an inexperienced drinker. The only way to get more drunk is to drink more alcohol. You can drink on an empty stomach, but that means you will just absorb more of the alcohol you drank and at a faster rate. If you want to help reduce the damage from alcohol then take a B vitamin supplement and maybe a magnesium supplement. This will help replenish the heavy loss of B vitamins that alcohol causes and therefore helps reduce harm to the liver. And of course prehydrate so you don't dehydrate and drink water through out the night.
 
To clarify, I'm not looking for drugs to take per say. I know I can mix opiates (and other drugs) with alcohol. I'm more interested in something available legally that I can buy that might lessen the amount I have to drink.

I'm not an inexperienced drinker though lol. And I know it's possible to do what I'm interested in doing.

It's common knowledge that when taking opiates you can eat foods (grapefruit) that inhibit a specific enzyme in your liver, causing you to feel more of an effect from (ie potentiate) the drugs. The same idea should apply to alcohol.
 
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Biovail said:
Hey guys,

so I'm not usually a heavy drinker, simply because of how bad it is for you. Tonight though, I want to get plastered. In the interest of harm-reduction, I'd like to get as drunk as possible while consuming as little alcohol as possible (since the metabolites of alcohol are even more damaging than the alcohol itself). Is there anything I can eat, drink, or otherwise consume that will potentiate the effect of alcohol over the course of the night?
Click to expand...

Drink (around) 5-6 shots of vodka. You'll be really drunk then. Once you're at that point. Do only two more shots, no more the rest of the night. You'll be extremely wasted, falling over yourself, probably start puking your guts up, etc. You won't die, but when you wake you'll wish you had.
 
drinking quicker works very well. drinking on little sleep or an empty stomach, too.

one thing i find to hugely impact my tolerance actually is drinking something you're not used to... you a beer drinker? get two bottles of wine. every 6 or 7 months i switch up my primary drink and my tolerance bottoms out.
 
Don't eat anything before and during and donate blood on the same day. That's the best you can do without mixing with other drugs.
 
This, but this is clearly very dangerous if done without causion... I would suggest that you dont try this with high doses and start very slowly.

By the way this work is not mine, Ive picked it up from another forum and im not the author.

P450 ENZYMES

CYP1A2

SPECIAL NOTES ON COFFEE
Coffee induces and inhibits CYP1A2. Inhibition is the initial effect, followed later by induction. Therefore coffee should NOT be used as a CYP1A2 inhibitor. Because coffee both inhibits and induces CYP1A2, it’s very difficult to categorize it in this fact sheet. It’s been shown in my own tests that using coffee at the onset and during the peak of the effects from allylbenzenes can greatly boost the effects. Why it does this is not known. It’s also been shown that drinking too much coffee throughout the day prior to using allylbenzenes seems to have a detrimental effect on the allylbenzenes. It’s assumed that this from CYP1A2 induction, but this is only a theory.
POTENT CYP1A2 INHIBITORS

Apigenin (from Parsley leaf, German chamomile flowers, but not the EO)
Capsaicin (found in cayenne pepper, habanero peppers, etc.)
Cayenne pepper: 500-800 mg
Chrysin (from Passiflora caerulea)
Echinacea purpurea
Galangin
German chamomile EO: 5-10 drops
German chamomile flowers: 5-10 grams
Kaempferol
Parsley leaf: possibly 200-500 mg (this needs to be confirmed)
Quercetin
Rutaecarpine (from Evodia rutaecarpa)
Salvia miltiorrhiza (danshen)
Starfruit juice
Tangeretin
CYP2A6

POTENT CYP2A6 INHIBITORS

Almond extract: 1/2 teaspoon
Anisaldehyde
Benzaldehyde (found in almond extract, and bitter almond essential oil)
Bergamot EO
Cassia EO
Cinnamaldehyde (found in cinnamon essential oil)
Cinnamon
Cinnamon EO: 5-10 drops
Lemon EO
Lime EO
Limonene
Neroli EO
Nootkatone (found in grape fruit oil)
Orange EO
Petitgrain EO
Safrole (found in sassafras and nutmeg)
Starfruit juice
Tangerine EO
MODERATE CYP2A6 INHIBITORS

Alpha-thujone
Lemongrass EO
Quercetin
Undecylic aldehyde
WEAK CYP2A6 INHIBITORS

Coumarin
CYP2A6 INHIBITORS (Unknown potency)

Acai berry oil
Bergamottin
Black pepper
caffeic acid
Cannabidiol
Grape Seed Extract
Naringin
Nicotine
Peppermint oil
White Grapefruit
CYP2C9

POTENT CYP2C9 INHIBITORS

5-hydroxyeugenol
Apigenin
Black pepper: 5 grams
Capsaicin (found in cayenne pepper, habanero peppers, etc.)
Cayenne pepper: 500-800 mg
Cinnamon
Cinnamon EO: 5-10 drops
Curcumin: 250 mg
Ginger
ginkgo biloba (high dose)
ginkgo biloba (low dose)
kava
pomegranate
Pummelo
Quercetin: 250 mg
Saint John’s Wort
Turmeric
White Grapefruit: 2 cups
MODERATE CYP2C9 INHIBITORS

Eugenol
Starfruit juice
CYP2C9 INDUCERS

DHEA (dehydroepiandrosterone)
Folic acid
Glycyrrhizin
Hyperforin
Licorice
Limonene
Orange EO
Retinoic acid
Rifampin
Saint John’s Wort (low dose)
Valerian root
Valerian root EO: 2-5 drops
POSSIBLE CYP2C9 INDUCERS (These activate PXR and probably induce CYP2C9)

Artemisia scoparia
Artemisinin
Atractylodes macrocephala
Berberine hydrochloride
Cafestol
Chinese angelica
Coptis chinensis
Curcumin (inhibits strongly before induction)
Epimedium brevicornum
Eugenol (inhibits strongly before induction)
Gardenia fruit
Ginkgo biloba (inhibits strongly before induction)
Guggulsterone
Ligusticum chuanxiong
Ligustilide
Luteolin
Lycium chinense
Milk Thistle
Ophiopogon japonicus
Paeonia lactiflora
Polygonum multiflorum
Rehmannia root
Resveratrol
Schisandra chinensis
Schisantherin A
Trichosanthes kirilowii
Turmeric (inhibits strongly before induction)
CYP2D6

POTENT CYP2D6 INHIBITORS

Cannabidiol (from Cannabis)
Echinacea purpurea
Goldenseal
Pomegranate juice (Punica granatum): 1 cup
Pummelo
Saint John’s Wort (high dose)
Starfruit juice
White grapefruit juice: 2 cups
MODERATE CYP2D6 INHIBITORS

Black pepper: 5 grams (ingest the solids, it's an ineffective inhibitor as tea)
Calamus EO: 3 drops
Kava
Pi. cubeba
Quercetin
Zingiber aromaticum
WEAK CYP2D6 INHIBITORS

Alpha-asarone (found in Calamus EO)
Black cohosh
Capsaicin (found in cayenne pepper, habanero peppers, etc.)
Cayenne pepper
Common sage
Cryptotanshinone
Curcuma heyneana
Curcumin
German chamomile EO
Ginkgo biloba
Habanero pepper
Milk Thistle
Safrole
Tanshinone I
Turmeric
CYP2D6 INDUCERS

Valerian root
Valerian root EO: 2-5 drops
CYP2E1

POTENT CYP2E1 INHIBITORS

Bergamot EO
Capsaicin
Cayenne pepper: 500-800 mg
Cinnamaldehyde
Cinnamon
Cinnamon EO: 5-10 drops (NOTE: cinnamon oil inhibits CYP2A6 more than CYP2E1)
Grapefruit EO
Lemon EO
Lime EO
Neroli EO
Orange EO
Petitgrain EO
Starfruit juice
Tangerine EO
MODERATE CYP2E1 INHIBITORS

Garlic EO
Kava
Mandarin EO
Safrole
WEAK CYP2E1 INHIBITORS

Myricetin
Turmeric
CYP2E1 INHIBITORS (Potency Unknown)

Acai berry oil
Bergamottin
Citral (geranial/neral)
Dihidrocapsaicin
Dimethylsulfoxide (DMSO)
Ellagic Acid
Garlic
Lemongrass EO
Limonene
Naringin
o-methoxycinnamaldehyde
propylene glycol
Quercetin
Resveratrol
Saint John’s Wort (high dose)
Silymarin
Tannic acid
White Grapefruit
CYP3A4

POTENT CYP3A4 INHIBITORS

Black pepper: 5 grams
Catechin (Green Tea)
Clove EO
Dillapiole: 3-5 drops as dill oil CT dillapiole
Echinacea purpurea
Eugenol (from in clove EO)
Ginger
Glabridin (from licorice)
Goldenseal
Licorice
Milk Thistle
Piperine (from Black pepper)
Pomegranate
Quercetin: 250-500 mg
Silymarin (from Milk thistle)
White Grapefruit: 2 cups
MODERATE CYP3A4 INHIBITORS

5-hydroxyeugenol
Calamus oil: 3 drops
Cinnamon
Curcumin: 250 mg
Kava
Starfruit juice
Turmeric
WEAK CYP3A4 INHIBITORS

Alpha-asarone
Black cohosh
Capsaicin
Cayenne pepper
Common sage
Elemicin
Garlic EO
German chamomile EO
Ginkgo biloba
Green Tea Extract
Habanero pepper
Methoxyeugenol
Methyl eugenol
Myristicin
Protocatechuic aldehyde
Saint John’s Wort (high dose)
 
Might as well say what's on everyones minds - take 10mg diazepam before drinking.
 
I always heard that asprin thins your blood thereby making someone more susceptible to the affects of alcohol. In the interest of HR, I wouldn't recommend this, either. Why not just pace yourself, have a nice glass of ice water between drinks so you don't get hungover, and call it an evening?
 
If you are looking for something similar to what GFJ or tagamet does for opiates/benzos it isn't going to reduce the amount of metabolites. It just slows down the speed at which its metabolized, but it all happens eventually. It makes sense for opiates because they are expensive, but alcohol is cheap so might as well just drink more. Honestly the damage from one night of binge drinking is not much to worry about.

And adding a benzo to it is not potentiating, its getting fucked up on 2 things. Of course IME it works well to get a good buzz with a small dose of a benzo and 3-4 beers. In place of drinking 8 or so beers. That way you end up avoiding a hangover, too. But its most certainly a combo to be done in moderation.
 
Very helpful QUARE, thanks. According to http://pubs.niaaa.nih.gov/publications/AA72/AA72.htm you want to slow down the enzyme alcohol dehydrogenase (ADH), responsible for metabolizing ethanol into acetaldehyde (very toxic) without inhibiting aldehyde dehydrogenase (ALDH). Fast ADH or slow ALDH will cause buildup of acetaldehyde, which I'm trying to avoid.

It looks like alcohol is also broken down into reactive radical oxygen species. So antioxidants would be a wise thing to consume during and after binge drinking. Will pomegranate Juice work for this or is that a hoax?
 
RTrain said:
And adding a benzo to it is not potentiating, its getting fucked up on 2 things. Of course IME it works well to get a good buzz with a small dose of a benzo and 3-4 beers. In place of drinking 8 or so beers. That way you end up avoiding a hangover, too. But its most certainly a combo to be done in moderation.
Click to expand...

Yes and it goes against HR which this board should be about which is why I didn't say it immediately. But it is kinda the obvious choice here.
 
I'm living next to the biggest party town in the United States and this weekend (Halloween) is the biggest party weekend of the year. Everybody is getting obliterated. This is my last year at school here and I want to be completely smashed. But I have to study for a midterm tomorrow and want to avoid a hangover as much as possible. And I don't have access to many other drugs.
 
Maybe we can help you with the hangover part? Ephedrine is still legal in the US right? That always got rid of any hangover I ever got.
 
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