Hallucinogens could unlock mystery of the brain

gloggawogga

Bluelighter
Joined
Dec 29, 2002
Messages
3,065
Location
Houston, TX
HALLUCINOGENS COULD UNLOCK MYSTERY OF THE BRAIN

Some Debate Practical Uses Of Ancient Practice

Long before Timothy Leary and Ken Kesey and the counterculture generation discovered hallucinogenic drugs, the Indians of western Mexico were using peyote to commune with their gods.

Anthropologist Peter T. Furst, who spent 30 years among the Huichol people, says that Indian shamans have been using hallucinogenic plants as a doorway to the divine for thousands of years, likely following a tradition carried by their ancestors over the Bering Strait.

And now, some U.S. scientists are exploring how these substances might be used by doctors to battle anxiety, mental illness and alcoholism.

"These compounds hold tremendous potential for helping us understand how the brain functions, and they have untapped potential for healing," said Charles Grob, a psychiatry professor at UCLA Medical School.

Some early studies suggest that LSD can ease the sense of dread that people feel when they are dying. "There were some very interesting and promising results," said Grob. He recently secured approval from the Food and Drug Administration to continue this line of inquiry using the milder drug psilocybin, the active ingredient in hallucinogenic mushrooms.

"We're really on the threshold of a new era of formal and very tightly controlled sanctioned studies with hallucinogens to study their safety and efficacy," Grob said.

An ancient practice

In Philadelphia, a new show on peyote-inspired Huichol art opened this month at the University of Pennsylvania Museum of Anthropology and Archaeology. Furst, curator of the exhibition, said these are religious images, created with the ritual use of the cactus plant.

"There's a difference in nature between people who use this for religion and those who are part of our counterculture," said Furst, 81. A German-born Jew, he moved to England and then the United States in the 1930s. A vaguely European accent gives him a serious, professorial air.

After writing for Stars and Stripes during World War II, Furst worked as a journalist for United Press before studying cultural anthropology. He made a specialty of studying shamanistic peoples and wrote numerous books, including "Hallucinogens and Culture."

He maintains that nearly all hunter-gatherer societies practiced shamanistic religions, which often used hallucinogens or other mind-altering techniques to see gods, the underworld, the meaning of life.

Though he left the Penn museum a few years ago to live in Santa Fe, Furst returned this month for the opening of the exhibit, "Mythic Visions," a display of a Huichol artform known as yarn painting. In depicting complex arrays of dancing deer, snakes and other figures, the artist tries to evoke the visions he experiences with peyote.

Small bands of Huichol travel for 300 miles to a desolate spot deep in the Chihuahuan desert to hunt for the squat, round peyote cactus. Furst said he participated in Huichol peyote hunts and ceremonies and found the plant extraordinarily unpalatable.

Archaeological finds in Texas show remnants of peyote that date back around 7,000 years. Even earlier finds show a hallucinogenic seed associated with remains of giant mastodons and other Pleistocene animals that go back at least 10,000 years.

Furst said he believed it was likely the Huichol and other tribes brought a tradition of hallucinogen use from Siberia before they entered the Americas more than 15,000 years ago.

'Divine inspiration'

Others see evidence for shamanism in early Europe. "Shamanism emerged at least 40,000 years ago and is reflected in Paleolithic rock art," said Michael Winkelman, an anthropologist from Arizona State University. "Not all societies depended on hallucinogenic plants but where they found them, people built up institutions around these substances," he said. "They are seen as a source of divine inspiration."

On Good Friday 1962, some researchers at Harvard gave a small group of divinity students either psilocybin or a placebo. Psilocybin, then legal, works much like peyote. "Eight of the nine people who got the drug reported they had had the most profound spiritual experiences of their lives," Winkelman said.

Hallucinogens act on receptors in the frontal cortex, sometimes called the executive part of the brain because it's used for higher reasoning, he said. They also act on a part of the brain called the thalamus, Nichols said, which works to help us distinguish what's novel and important. That may explain why people on LSD can become mesmerized by a flower or by their own hand.

Effect on alcoholism

John Halpern, associate director of substance abuse research at Harvard University and McLean Hospital, is investigating the possibility that peyote prevents alcoholism in American Indians.

In a study he plans to publish within the next several months, he compared cognitive and psychological health measures among Indians who were alcoholics, those who regularly used peyote, and those who used no drugs or alcohol.

Halpern said he can't reveal his study's results yet, but he will say he sees no evidence that peyote damages the brain. "There's no history of it being addictive, or trafficked or abused," he said. Peyote can be dangerous if people use it to get stoned and then do stupid things, he said, but that's not what happens in religious ceremonies.

Others, such as David Murray of the Office of National Drug Control Policy in Washington, see more serious risk. Working among the Navajo, he said, he found long-term peyote use was "counterproductive to education and social mobility."

Because the peyote comes from a natural plant, he said, "you're taking in a powerful chemical stew," with some toxins in addition to the psychoactive ingredient. "It is, without question, a risky undertaking."

From http://www.sunherald.com/mld/sunherald/news/world/7572566.htm
Also archived at: http://www.mapinc.org/drugnews/v03/n1993/a04.html?397

Posted on Fri, Dec. 26, 2003
 
Last edited by a moderator:
Because the peyote comes from a natural plant, he said, "you're taking in a powerful chemical stew," with some toxins in addition to the psychoactive ingredient. "It is, without question, a risky undertaking.
----

Ok, then I'll choose some pure mescaline... but oh wait, it seems you have made this choice rather illegal... all part of the big plan I guess?

You all know the big plan right... protect the alcohol and tobacco industries... wouldn't want any competition from other drugs, ya know, the ones which may be "counterproductive to education and social mobility."

oh wait, I thought that WAS alcohol and tobacco..

some nice typical BS from the Office of National Drug Control Policy...

But hey, that is the only BS in this article. Accurate information, good writing with a nice breakdown of the background and medical uses. The author even throws in the good friday experiment for good measure.
 
Very interesting stuff. I'm going to move this bad boy over to the Front Page :)
 
gloggawogga said:
Peyote can be dangerous if people use it to get stoned and then do stupid things, he said, but that's not what happens in religious ceremonies.

well said and argees 110% ..... its not a party thing or something to do all the time........its a powerful plant. But I can tell you its a amazing experience in your own comfortable surroundings.

Because the peyote comes from a natural plant, he said, "you're taking in a powerful chemical stew," with some toxins in addition to the psychoactive ingredient. "It is, without question, a risky undertaking.".

lol yeah..... according to this site

There have been over sixty alkaloids discovered in this plant which has been described as a " little green chemical factory ". This Cactus is known to contain 56 nitrogen containing compounds derived from a tyrosine base, as well as 20 tyramine-like alkaloids. Mescaline content usually ranges from about 3 - 6%, by dry weight, averaging around 4%, but is highly variable. Most of the alkaloids present can be classified as B-phenethylamines like mescaline or tetrahydroisoquinolines like hordenine. These chemicals differ in structure from LSD in that they don't have a complete indole ring. Mescaline content of fresh, undried cactus is reported at 0.4 %.



Contains: N-acetyl-3-methoxy-4,5-dimethoxyphenethylamine, alanine, anhalamine, anhalidine, anhalinine, anhalonidine (14% of the total alkaloids), anhalonine, anhalotine, 3,4-dihydroxy-5-methoxyphenethylamine, epinine, dopamine, 3,4-dimethoxyphenethylamine, N-acetylanhalamine, N-acetylanhalonine, N-formylanhalamine, N-formylanhalinine, N-formylanhalonidine, N-formylanhalonine, N-formyl-O-methylanhalonidine, N-formyl-3-methoxy-4,5-dimethoxyphenethylamine, glycine (8% of the total alkaloids), hordenine, 3-hydroxy-4,5-dimethoxyphenethylamine (1 to 5% of the total alkaloids), isoanhalamine, isoanhalonidine, 3-hydroxy-4,5-dimethoxy-N-methylphenethylamine, isoanhalidine, isopellotine, lophophorine (5% of the total alkaloids), 3-hydroxy-4,5-dimethoxy-N,N-dimethoxyphenethylamine, lophorine, lophotine iodide, mescaline (30% of the total alkaloids), mescaline citrimide, mescaline malaimide, mescaline maleimide, mescaline succinimide, isocitrimide lactone mescaline , N-acetylmescaline, N-formylmescaline, N-methylmescaline, mescalotam, 3-methoxytyramine, 3-methoxy-N-methyltyramine, 3-methoxy-N,N-dimethyltyramine, O-methylanhalonidine, O-methylpeyoxylic acid, O-methylpeyoruvic acid, N-methyltyramine, pellotine (17% of the total alkaloids), peyoglunal, peyoglutam, peyonine, peyophorine, peyouvic acid, peyotine iodide, peyoxylic acid, tyramine.

I love my Lophobora williamsii's chemical factories...... I think my avatar explains enough =D
 
So... ummm... how are they supposed to unlock the mystery of the brain?

They mentioned some stuff about the frontal cortex and where lsd is active, but the mystery of the brain?

My brain tells me that it is a formalized system incapable of understanding itself.

But, hey it is a positive article, so why complain? :\
 
gloggawogga said:

Some early studies suggest that LSD can ease the sense of dread that people feel when they are dying. "There were some very interesting and promising results," said Grob. He recently secured approval from the Food and Drug Administration to continue this line of inquiry using the milder drug psilocybin, the active ingredient in hallucinogenic mushrooms.

Right.... because psilocybin and lsd are... the same........

"There's a difference in nature between people who use this for religion and those who are part of our counterculture," said Furst, 81. A German-born Jew, he moved to England and then the United States in the 1930s. A vaguely European accent gives him a serious, professorial air.

and this difference would be what exactly?

Small bands of Huichol travel for 300 miles to a desolate spot deep in the Chihuahuan desert to hunt for the squat, round peyote cactus. Furst said he participated in Huichol peyote hunts and ceremonies and found the plant extraordinarily unpalatable.

so it didn't taste good? So much so that you couldn't eat it? I see...

On Good Friday 1962, some researchers at Harvard gave a small group of divinity students either psilocybin or a placebo. Psilocybin, then legal, works much like peyote. "Eight of the nine people who got the drug reported they had had the most profound spiritual experiences of their lives," Winkelman said.

am I the only one who, given the strength and obviousness of the drug, thinks the control group is useless in this situation?



I didn't like this article. I give it props for saying that hallucinogens have value, but otherwise I didn't like it.
 
the next thousand years should be an interesting time for psychedelics.

the genie IS out of the bottle now, and somone's going to have to put the bit in it's mouth. why not big brother?

oh, but im being paranoid.

Anyway, good reading glog! big ups!

-j.
 
This article is almost an exact replica of one i posted about a year ago. Are you sure we dont allready have this in the archives? I looked but couldnt find, but im damned sure this article was previously posted. Its a good one, allthough its written so that the misinformed and uninformed can understand it.

...using the milder drug psilocybin...

above lies the understatement of the year :\

Psilocybin, then legal, works much like peyote

uhm... no? no comment...

Food for thought: if these wonderful gifts from mother nature are such a blessing to society, why are they illegal?
 
Whats so new about this? There have been numerous studies on psychedelics before. I wish there more studies of course, but it seems like this article is trying to say that this somehow a new area of research. Maybe I read it wrong...

Either way, whatever study they will complete, any positive results from it will lead to the government saying that it is wrong. I just can't see how this is anything new, and what exactly are they planning to even research? It seems kind of ambiguous.
 
THE WOOD said:
above lies the understatement of the year :\


well psilocybin is less potent than LSD ... LSD is active in humans, in micrograms (as im sure you know)
 
A very nice article, hopefully more research and development lies ahead of us.

THE WOOD said:
Food for thought: if these wonderful gifts from mother nature are such a blessing to society, why are they illegal?

They are probably illegal 'cause they are the key to understanding parts of our mysterical brain. Something feared by politicians and other unscientific orientated folks.

Originally posted by kbee
well psilocybin is less potent than LSD ... LSD is active in humans, in micrograms (as im sure you know)

heheh ;)
 
I think that the government shouldnt interfere with ppl trying to find insight into theyre own psyche. its our brain, why cant we decide what we put in it.

and there are definately many, many possibilities of potential treatments that hallucinogens could bring about. theres a reason ppl have been using it since the dawn of humanity.

ever think about what seperates us from the other animals? the mind. ever since our earliest ancestors decided to expand their minds, and climb out f the trees, or rub two sticks together our kind has been thinking. and what can help us to think? how about looking at things from a different state of mind. perhaps under the influence of a chemical amine?
 
Top