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Misc Going for Plateau Sigma (DXM)

Grigore

Grigore

Bluelighter
Joined
Jan 8, 2014
Messages
263
Location
Cemetery
I have cyp2d6 enzyme deficiency.
That means,I get way higher on dxm than most people and I'm not quite sure if this is some sort of a blessing,cuz I ended up in hospital from 800mg of dxm combined with 2 grapefruits (had a NDE actually)

What dosage should I use to reach plateau sigma?

I was thinking about:

200mg,3 hours later-200mg,3 hours later-400mg. (800mg total)

Is it relatively safe?

*I usually reach 2nd plateau with a 200mg dose.
 
Grigore said:
...Is it relatively safe...
Click to expand...

NO


Even for healthy people, sigma plateau is dangerous - for you it's VERY dangerous...

A CYP2D6 deficiency with DXM will actually mean you get less DXO, the active dissociative, and more DXM...the SSRI...

DXM is not a safe drug for you to use - for the record it will take MORE DXM to get you to the right plateau, not less...but your body will also not handle DXM very well...so for you, the higher plateaus are not only impossible to reach, but also super dangerous...sorry man DXM is not for you.
 
damn,I'm a bit confused now because,I just realized that most of my dxm experiences occur in the same plateau,even if I take different dosage.
Its not even a plateau described by other people,its just an unique fucked up high that lasts 4 days in my case.

So,what should I do? Take a lower dose and just stick with tripping 4 days and never reaching plateau sigma?
Are you sure that I cant reach it?
 
... How exactly do you know that you're 2D6 deficient?

And No Warn!ng's right, about everything. If indeed you are 2D6 deficient, and have medical confirmation...
 
well,this might not be the best proof,but,I'll mention it:
Im getting very high from doses as small as 100mg.
And I tripped waaay harder than a friend of mine,on the same dose. (both of us had no tolerance) (we tripped together and I was fucked up for 3 days,next day he was completely fine - 400mg was the dose)
 
Sigma plateau doesnt looks fun and is dangerous, why would you want to reach it...

Plateau Sigma: 2.5–7.5 mg/kg every three hours for 9–12 hours; occurs by prolonging dosage. Plateau sigma is marked by the presence of psychosis with visual and auditory hallucinations. Users have reported that inclinations manifest as auditory hallucinations; rather than simply feeling tired and sitting down, a user might hear a voice saying, "sit down now, you're tired," and feel inclined to obey. White says that of all the reports of Plateau Sigma experiences he received, over half were described as unpleasant.

Source: Wiki
 
Grigore said:
well,this might not be the best proof,but,I'll mention it:
Im getting very high from doses as small as 100mg.
And I tripped waaay harder than a friend of mine,on the same dose. (both of us had no tolerance) (we tripped together and I was fucked up for 3 days,next day he was completely fine - 400mg was the dose)
Click to expand...

That would be evidence that you are actually an ULTRA-RAPID metabolizer. As previously mentioned, DXM is really a pro-drug for DXO, at least for these purposes.
 
OP, I believe you 100% that you get effects from small doses - but if you have a CYP2D6 deficiency, You're just feeling DXM, not much DXO will be produced, and DXO is the main active ingredient in a DXM "plateau" experience.

So you probably are having more of a "ecstasy"-like experience than you're supposed to be having, because DXM is mainly a SSRI and not much of an NMDA antagonist.

DXM is also more dangerous than DXO, because at higher doses it can give you a seizure.

You probably do get very intoxicated from small amounts of DXM, but it's not the "right kind" of intoxication, if that makes sense.
 
Well,I was having a seizure when I've taken 800mg with 2 grapefruits.
Lorne said above that,maybe,I'm actually an ultra rapid metabolizer.

So,these 2 infos are quite contradictory I think,can I be an ultra rapid metabolizer and have a CYP2D6 deficiency in the same time? (The fact that I had a seizure from a relatively high dose might be proof that I have a CYP2D6 deficiency)
 
I'm not really saying you're an ultra-rapid M. My point is that, we don't know either way. The fact that you get "high" from low doses of DXM isn't proof either way.

You can argue you're deficient, and ergo get enhanced effects from a low dose, I can argue you get a double dose of DXO, therefore doubling the experience.

Don't take this the wrong way, but you can't simply read a wiki article, and then proclaim yourself a "poor" 2D6 metabolizer, it doesn't work that way.
 
Grigore said:
well,this might not be the best proof,but,I'll mention it:
Im getting very high from doses as small as 100mg.
And I tripped waaay harder than a friend of mine,on the same dose. (both of us had no tolerance) (we tripped together and I was fucked up for 3 days,next day he was completely fine - 400mg was the dose)
Click to expand...

As you can see, it is merely a guess. Hope this fucking guy doesn't plan on mixing amp and DXM...
 
N0 W4RN1NG said:
Did you receive Doctor's word that you have low CYP2D6 function? Or is it just a guess?
Click to expand...
just a guess,nothing is for sure,but there are some things that we should take consideration of.
I'll try to reach plateau sigma anyway,I hope I won't reach the hospital instead.
 
Ahh. I don't mean to be rude at all, but are you Asian, Grigorne? Because I know the Asians are understood to have a higher likelihood of low CYP2D6.

If not, you are actually probably a normal metabolizer of CYP2D6...

And yes as Lorne said, you should never mix amphetamines with a recreational dosage of DXM. Small amounts of DXM (30-60mg) are fine, I do that all the time and it helps with duration and tolerance, but "tripping" on DXM with amphetamines is a BIG no-no.
 
N0 W4RN1NG said:
Ahh. I don't mean to be rude at all, but are you Asian, Grigorne? Because I know the Asians are understood to have a higher likelihood of low CYP2D6.

If not, you are actually probably a normal metabolizer of CYP2D6...

And yes as Lorne said, you should never mix amphetamines with a recreational dosage of DXM. Small amounts of DXM (30-60mg) are fine, I do that all the time and it helps with duration and tolerance, but "tripping" on DXM with amphetamines is a BIG no-no.
Click to expand...

Well I hope you've never taken 400mg DXM and 125mg amp simultaneously!!! JK,JK
 
N0 W4RN1NG said:
Ahh. I don't mean to be rude at all, but are you Asian, Grigorne? Because I know the Asians are understood to have a higher likelihood of low CYP2D6.

If not, you are actually probably a normal metabolizer of CYP2D6...
Click to expand...
You weren't rude at all,BUT PLEASE SPELL MY NAME CORRECTLY :D
I'm not asian,my genes are mixed anyway and I can tell for sure that something is wrong with how I metabolize DXM because I definitely get much higher than normal people on the same doses.
 
If I've been declared as "allergic to Robotussin", could one infer that I might have one of these two health issues described above? I've had shocking effects from 60mg over 8 hours.
 
No, if you have an actual allergic reaction (histamine surge) then your liver, and therefore enzymes, probably have little to do with it.

@ Grigore: Sorry for typo :)
 
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