Misc GHB & Prolactin

[Defy]

Hey guys i've been reading up on GHB about the Growth Hormone Rise but recently came to learn about the prolactin rise (which is to counteract the GH rise true?). Well prolactin is somthing I really don't want to rise (and apparently it is a big increase of up to 5x). I'm wondering a few things, how long is prolactin elevated for. I think GHB has a half life of about 1 hour does this mean prolactin is only elevated for an hour or does it rise or remain elevated after?

Second question, would it be wise to look into using a somthing that helps stop prolactin such as vitamin B6 or L-Dopa before? I know a sure way would be to use dostinex or bromo or somthing but I don't think I'm willing to use those.

Thanks

 

[Swimmingdancer]

Hey guys i've been reading up on GHB about the Growth Hormone Rise but recently came to learn about the prolactin rise (which is to counteract the GH rise true?)

What do you mean "counteract"? Growth hormone and prolactin are similar in structure. Growth hormone-secreting cells and prolactin-secreting cells develop from a common progenitor cell. In certain situations when one of these two hormones is oversecreted the second hormone is too. Prolactin does not counteract growth hormone to my knowledge, (maybe you were thinking of the fact that prolactin inhibits gonadotropin-releasing hormone secretion?)

Well prolactin is somthing I really don't want to rise (and apparently it is a big increase of up to 5x). I'm wondering a few things, how long is prolactin elevated for. I think GHB has a half life of about 1 hour does this mean prolactin is only elevated for an hour or does it rise or remain elevated after?

I think this will be very hard to find out, the best study I could find on the topic didn't say how long prolactin was increased for.

GHB having a half-life of around 1 hr just means that half the GHB should be eliminated by that time, not that it's out of your system or no longer affecting you after 1 hr. If you consider 5 half-lives as the elimination time, that would be around 5 hrs for it to be eliminated. But unfortunately that still doesn't tell us how long prolactin levels are raised for. It's possible it could elevate prolactin longer than it's even in your system.

Second question, would it be wise to look into using a somthing that helps stop prolactin such as vitamin B6 or L-Dopa before? I know a sure way would be to use dostinex or bromo or somthing but I don't think I'm willing to use those.

Well, I can't say whether or not that would be wise - are you taking GHB frequently?

I read this about B6 on another forum:

Spoiler: Vitamin B6 Prolactin Inhibition

Vitamin B6

Vitamin B6 is a surprisingly effective prolactin inhibitor that is extremely cheap and safe: One human study showed a single 300mg dosage of B6 exerts ‘a hypothalamic dopaminergic effect’ which causes a ‘significant decrease of plasma prolactin’.

Side effects:
High doses of B6 taken for many months can cause nerve problems such as tingling in the fingers and numbness in the toes (peripheral neuropathy); B6 can also worsen sleep quality in some people and cause vivid dreams.
Fortunately, these problems completely resolve once B6 supplementation is stopped and, since it is water soluble, this won’t take too long.

Ways around these side effects:
One way to avoid the ‘finger tingling’ that high dose B6 can cause is to take the activated form of B6 called Pyridoxal-5-Phosphate (P5P) - the activated form of B6 does not cause these nerve issues.
In fact, the reason that high dose B6 causes nerve problems is that the body can’t always process very high B6 doses properly and this creates a deficiency of the active form of B6, P5P.

Recommended dosage:
To lower prolactin levels I would recommend you take 50 to 200mg of P5P a day, in divided doses. If you want to take regular B6, which as I've mentioned can sometimes cause minor side effects, take 300 to 1000 mg per day in divided doses.
Read the label before you buy B6 because the Pyridoxine Hydrochloride type of B6 (in most supplements) has been shown to be a prolactin inhibitor but Pyridoxal hydrochloride has been shown to be ineffective at lowering prolactin (6) – make sure you buy the right type!

 

[pasha]

Hey guys i've been reading up on GHB about the Growth Hormone Rise but recently came to learn about the prolactin rise (which is to counteract the GH rise true?). Well prolactin is somthing I really don't want to rise (and apparently it is a big increase of up to 5x). I'm wondering a few things, how long is prolactin elevated for. I think GHB has a half life of about 1 hour does this mean prolactin is only elevated for an hour or does it rise or remain elevated after?

Second question, would it be wise to look into using a somthing that helps stop prolactin such as vitamin B6 or L-Dopa before? I know a sure way would be to use dostinex or bromo or somthing but I don't think I'm willing to use those.

Thanks

Well, there is some truth to what you're saying. GHB causes significant secretion in prolactin due to its hypothesized activity at the hypothalamus gland more specifically the pituitary gland, or its activity at 5-ht. High levels of prolactin (hyperprolactinemia) have shown to inhibit testosterone levels, a growth hormone in itself. I think this is the concern you speak of in regards to body builders.

 

[Swimmingdancer]

^I wouldn't call testosterone a "growth hormone" (even though it plays a role in growing muscle and bone etc), I think the term "growth hormone" is only used to mean the growth hormone (GH). Maybe the term "human growth hormone" (HGH) would be clearer. GHB increases HGH and prolactin. I think that's what the OP was talking about when referring to "growth hormone rise". But yeah, high levels of prolactin would be unwanted for a number of reasons

 

[pasha]

You're right, it isn't in the traditional sense of the word (somatropin).

"A hormone responsible for growth" would have been clearer wording on my part. Thanks for pointing that out.