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Esoteric GABA & Serotonin Agonist Coadministration

Esperighanto

Esperighanto

Moderator: PD, MDMA, DS
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Hey guys, just wanted to get a thread going to contain talks of GABA based hallucinogens being mixed with psychedelics.

I've mixed things like LSD & GHB, 2C-B & Etizolam, 5-MeO-DiPT & Soma, etc. and it usually rounds out the experience while dulling the visuals a little bit. Ambien and lorazepam have led to experiences with profundity comparable to heavyweights like ayahuasca on their own, in my personal experience. It seems like not everybody trips off Ativan, maybe 5% or less I'm guessing based on the studies' listed side effects.

Both Ambien and Soma have led to accidental potentiation of psychedelics in the past, and they had intense and profound effects resulting from their presence, where otherwise the trip would've been somewhat forgettable. On their own though they're just a nice high, what the fuck is that about? I must be scratching my head right now the same way the first panther in the Amazon did, when they realized that you chew the Banisteriopsis caapii BEFORE chewing the Psychotria viridis.

Soma and acid is the best feeling I've ever felt that isn't harmaline and acid. They're like yin and yang.

TLDR; Has anybody here ever explored these more hallucinatory GABA agents alongside traditional or RC psychedelics?
 
paranoid android said:
I took about 7 7.5mg zopiclone with a 1/8th of penis envy on the comedown once. I wet to sleep then woke up and ate a entire cake lol
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That's fucking awesome. Upon acquiring my first gram of crystal Etizolam I dosed 5mg with zero tolerance and blacked out, unconscious for 18 hours waking only to drink an entire gallon of milk in front of my boyfriend-at-the-time. I've no memory of it but there were even other witnesses who corroborated my now fiance as to the fact that I was only taking breaths as I needed to, like a small child desperately drinking water on a hot day and running out of air in his lungs.
 
lorazepam's low lipid solubility makes it relatively slowly absorbed by any route other than intravenously, but once injected, it will not get significantly redistributed beyond the vascular space. Therefore, lorazepam's anticonvulsant effects are more durable, thus reducing the need for repeated doses.

Something like liver only do lorazepam glocoronide and that low lipid means that it is not hold in fat cells like diazepam so meaning it's very soluble as we knoe there are number of pills global that works very fast sublingualy.

now what that means for trippy effects well, that I dont know but I also when was taking it felt always like something is in my peripheral side or that some part of unmoving objects are moving which wasnot bad

but also lorazepam is only benzo that gave me delusion of sobriety so be careful
 
I'm curious about the GABA/Serotonin thing, too, now, because (at a point, and you don't need to take that much) Gaaba basically washes Serotonin out of the brain. That's why benzo's or gabapentinoids can end up causing depression, and why you're not supposed to drink on SSRIs etc.
 
ĐmantuNJofra said:
lorazepam's low lipid solubility makes it relatively slowly absorbed by any route other than intravenously, but once injected, it will not get significantly redistributed beyond the vascular space. Therefore, lorazepam's anticonvulsant effects are more durable, thus reducing the need for repeated doses.

Something like liver only do lorazepam glocoronide and that low lipid means that it is not hold in fat cells like diazepam so meaning it's very soluble as we knoe there are number of pills global that works very fast sublingualy.

now what that means for trippy effects well, that I dont know but I also when was taking it felt always like something is in my peripheral side or that some part of unmoving objects are moving which wasnot bad

but also lorazepam is only benzo that gave me delusion of sobriety so be careful
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It's interesting you mention that, benzos with exposed hydroxyl groups (like oxazepam) also metabolize in weird pain in the ass ways. At this time I was dealing with a pretty intense amount of brain damage from surgeries (I was terminall ill for 3 years, way back when), and I was rx'd an arbitrary amount of lorazepam and hydromorphone, neither of which were good for my teenaged brain at that time. Nowadays that the brain damage has recovered, I'd be curious to see if lorazepam still fucks me up in that Ambien-like way. I've never experienced delusions of sobriety from any dose of a benzo that is even kind of noticeable relative to bodyweight, but I've taken possibly sub-threshold doses before and not noticed it, just to see where the threshold is. 300ug of etizolam, 300ug of bromazolam, 250ug of alprazolam, etc are the points where if I push higher I'll begin to notice it at least. Diazepam takes maybe 2-3mg for me to start feeling it, but I also weigh a hundred kilos (220 lbs).
ChemicallyEnhanced said:
The name made me lol xD
Is it called that because some mushrooms kinda look like micropenises?
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People who grow will notice that mushrooms vary a ton in size in the same bin, from the same variety. Often the smaller ones, "aborts", are the most potent by weight. I've had .5g of albino penis envies hit harder than 10g of golden teachers, just because the growing conditions of both varied so heavily that it impacted potency.
ChemicallyEnhanced said:
I'm curious about the GABA/Serotonin thing, too, now, because (at a point, and you don't need to take that much) Gaaba basically washes Serotonin out of the brain. That's why benzo's or gabapentinoids can end up causing depression, and why you're not supposed to drink on SSRIs etc.
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I've had a very difficult time finding peer reviewed literature as it pertains to the relationship of GABA and serotonin, do you have any sources on this? I've been able to avoid serotonin syndrome a couple times back in my ayahuasca days by drinking a fifth of liquor essentially with no stop from starting drinking to stopping drinking, after I'd made the mistake of crossing ayahuasca and hawaiian baby woodrose. The hypothesis that depression is rooted in a lack of depression is also true but it isn't always the root, sometimes for people depression is rooted in other causes. Currently we all use the word depression to refer to what is likely a variety of different things, and while some may be due to serotonin being too low, if SSRIs don't help somebody's depression, I'd be willing to bet they have whatever variety of depression isn't tied to serotonin. SSRIs don't do jack shit for me, I'm pretty sure my depression is rooted in issues with norep and dopamine though because bupropion zaps my depression away, but also makes me kind of bipolar-ish and my mood spirals way easier than when I'm not using bupropion in the last couple of days.

I suspect that the reason ERs administer benzos to people bugging out on psychedelics isn't because it undoes the psychedelic, it simply doesn't, I've watched this occur numerous times outside of clinical settings. It just makes them now also be on a benzo, and therefore less likely to freak out. My primary interest with this thread is exploring the possibility of therapeutic enhancement for psychedelics, carisoprodol not only amplifies LSD but also makes it a much more therapeutically applicable drug unless you hit a blackout point with the dose. ~1/3g of carisoprodol and 1-2 drops of acid is usually good for me and those around me.
 
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