Found study: Buprenorphine binding affinity vs naltrexone
Its a topic thats been brought up millions of times, but I just wanted to post a link to a study I just found today while researching it,,,,again. Its for science and improvig or creating new drugs that can help recovering addicts of opiates (like myself, 6years on smack, currently 3 off). Im thinking that, if buprenorphine really does have a higher affinity for receptors than naltrexone (and naloxone as well, allthough this study is only on naltrexone), a new drug should be in development that can use the binding affinity properties of bup, and some of the "anti-addictive" (anti-dopamenergic, TLR4 antagonsitic) properties of, say (+)-naloxone?--which has no affinity for any opiate receptors, but can, in laymans terms, through the actions discribed above (anti-dopamenergic, TLR4 antagonistic), reduce the "euphoric and addictive properties of opiod analgesics" but keep the painkilling aspec of them. While I am a skeptic, and never thought it possible to create an opiate drug that relieves pain effectively, yet creates no euphoria or addictive potential, I came across buprenorphine about twenty years ago and that blew my mind.
Anyways, two different topics going here at the same time 1- for you users out there stuck on Vivitrol or any other forms of naltrexone, yes, I personally do belive that any dose in any roa of buprenorphine will activate the opiate receptors and will have a higher affinity than naltrexone..............and 2. any thoughts on a combo buprenorphine and (+)-naloxone (dextro-naloxone)??
here is the link to the study--Essentially, they put long term methadone users into withdrawl using naltrexone, then "rescued them" (their words, not mine) using bupe, and they felt better. Hence, the conclusion that bupe has a higher affinity than naltrexone, and probably any other opiate or opiate peptide known to man at this point,,,yes??? haha
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719550/
Its a topic thats been brought up millions of times, but I just wanted to post a link to a study I just found today while researching it,,,,again. Its for science and improvig or creating new drugs that can help recovering addicts of opiates (like myself, 6years on smack, currently 3 off). Im thinking that, if buprenorphine really does have a higher affinity for receptors than naltrexone (and naloxone as well, allthough this study is only on naltrexone), a new drug should be in development that can use the binding affinity properties of bup, and some of the "anti-addictive" (anti-dopamenergic, TLR4 antagonsitic) properties of, say (+)-naloxone?--which has no affinity for any opiate receptors, but can, in laymans terms, through the actions discribed above (anti-dopamenergic, TLR4 antagonistic), reduce the "euphoric and addictive properties of opiod analgesics" but keep the painkilling aspec of them. While I am a skeptic, and never thought it possible to create an opiate drug that relieves pain effectively, yet creates no euphoria or addictive potential, I came across buprenorphine about twenty years ago and that blew my mind.
Anyways, two different topics going here at the same time 1- for you users out there stuck on Vivitrol or any other forms of naltrexone, yes, I personally do belive that any dose in any roa of buprenorphine will activate the opiate receptors and will have a higher affinity than naltrexone..............and 2. any thoughts on a combo buprenorphine and (+)-naloxone (dextro-naloxone)??
here is the link to the study--Essentially, they put long term methadone users into withdrawl using naltrexone, then "rescued them" (their words, not mine) using bupe, and they felt better. Hence, the conclusion that bupe has a higher affinity than naltrexone, and probably any other opiate or opiate peptide known to man at this point,,,yes??? haha
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719550/
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