Hey guys, my apologies if this becomes in the Other Drugs forum instead.
I've used MDMB-4en-PINACA, Δ8, Δ9, Δ10/Δ6, THC-H, THC-B, THC-P, THC-O, THC-PO, HHC, and HHC-O as far as I can recall. I've often eaten upwards of numerous grams of Δ9 THC and had a fantastic time, I don't believe that I have a capacity to get "too high". I am interested in exploring further synthetic/semi-synthetic cannabinoids, but it seems difficult to find adequate research when digging through academic literature on the matter, and the dizzying amount of synthetic cannabinoids doesn't help this research either. It's even further obscured by how they were often sold without the ingredients/dosages listed, so people were often just consuming mystery compounds (or mixes thereof).
Some common synthetic cannabinoids such as JWH-018 seem relatively non-toxic, however I found evidence of a single metabolite of it that's somewhat toxic. Some of these though, such as dexanabinol (also referred to as HU-211) are pharmacologically quite unique, being predominantly NMDA antagonist as opposed to just traditional CB1/CB2 agonism. There certainly appear to be unique synthetic (and semi-synthetic) cannabinoids out there, which if used sparingly and in highly controlled doses, could create fascinating experiences.
I wanted to cast an open question to BLers here about this, and see what people have enjoyed, found useful, and found the least damaging overall, whether through personal use or academic research. Thank you in advance for any information or personal experiences on the subject!
I've used MDMB-4en-PINACA, Δ8, Δ9, Δ10/Δ6, THC-H, THC-B, THC-P, THC-O, THC-PO, HHC, and HHC-O as far as I can recall. I've often eaten upwards of numerous grams of Δ9 THC and had a fantastic time, I don't believe that I have a capacity to get "too high". I am interested in exploring further synthetic/semi-synthetic cannabinoids, but it seems difficult to find adequate research when digging through academic literature on the matter, and the dizzying amount of synthetic cannabinoids doesn't help this research either. It's even further obscured by how they were often sold without the ingredients/dosages listed, so people were often just consuming mystery compounds (or mixes thereof).
Some common synthetic cannabinoids such as JWH-018 seem relatively non-toxic, however I found evidence of a single metabolite of it that's somewhat toxic. Some of these though, such as dexanabinol (also referred to as HU-211) are pharmacologically quite unique, being predominantly NMDA antagonist as opposed to just traditional CB1/CB2 agonism. There certainly appear to be unique synthetic (and semi-synthetic) cannabinoids out there, which if used sparingly and in highly controlled doses, could create fascinating experiences.
I wanted to cast an open question to BLers here about this, and see what people have enjoyed, found useful, and found the least damaging overall, whether through personal use or academic research. Thank you in advance for any information or personal experiences on the subject!
