Bravoncius Roxford
Bluelighter
- Joined
- Feb 1, 2017
- Messages
- 105
Once again you link the cancer cell line study and now a liver cell study, you're not showing any appreciable apoptosis in neuronal cell lines, much less that this has meaningful in vivo implications
The title of one paper you linked
"Sertraline, an Antidepressant, Induces Apoptosis in Hepatic CellsThrough the Mitogen-Activated Protein Kinase Pathway"
I just posted evidence that TCAs actually lead to decreased risk of neurodegenerative disease earlier, so I don't know why you're claiming TCAs are worse. Also, anticholinergics are not causing their deleterious effects on the brain through NMDA antagonism/olney's lesions, and olney's lesions are very unlikely to occur in humans.
The issue at hand for you is not whether or not SSRIs lead to apoptosis of neurons in vivo, but rather whether they can cause adverse effects (why would you limit the adverse effects of psychiatric meds to apoptosis?)
The other issue is the actual pathology of depression and neuropsychiatric disease from which you suffer - don't tunnel vision on apoptosis. Especially not SSRI induced apoptosis in cancer/hepatic/yeast cell lines.
Also, the burden of proof is not on me here, you're the one making the truth claim (that SSRIs cause appreciable apoptosis)
Rumination is a big part of depression that is both a symptom and a causal factor. Try mindfulness to stay in the present, learn mindfulness through an app like Headspace.
Several of the papers I posted dfiscussed that SSRIs induce apoptosis in *neuroblastomas*. Yes, those are cancerous cells, but nerve ones. Also, what does it matter if it is hepatic cells, or heart cells or any other kind of cell? All cells work the same. They all have mitochondria and they are all succeptible to the same toxicicity. Poisons are toxic to pretty much all cells in the body. Alcohol, for instance, poisons brain cells and hepatic cells and all other kinds of cells. I don't understand why you bring this up. The studies I posted clearly indicate an increase in inflammation in *healthy nerve tissue*. The apioptic markers were weaker than in cancerous cells, granted, but the SSRIs do increase markers of apoptosis in healthy nerve tissue as well.
As for why I don't focus on other adverse effects, it is because obviously destruction of brain tissue is a much more serious side effect than any other except for maybe serotonin syndrome which can be fatal.This is why I focus on apoptosis.
Also, my original claim is that the SSRIs *probably* are neurotoxic. I posted evidence of increased inflammatory markers in healthy brain tissue as evidence that they potentially harm the brain. You, conversely, flat out stated that these drugs are 100% safew to the brain in therapeutic doses. Well, what evidence do you have? You still haven't posted *one* study where the SSRIs are proven to be hamrless to human nerve cells in therapeutic doses.