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Misc Etizolam + Tramadol

Bahamut

Bahamut

Bluelighter
Joined
Jan 25, 2012
Messages
119
Location
Can'-Ka No Rey
I would like to find out about the safety of combing these two medications.

From what I understand they both have effects on the serotonin system, but I have heard it mentioned in other threads that people have combined them successfully without any complications. But other than those personal reports, I would like to hear a more scientific explanation about why or why not these two drugs can be mixed with one another. I'm very interested in combing these two medications if I could do so safely, any feedback you have relating to this topic would be greatly appreciated.

L<3Ve & Lite

~Bahamut
 
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Etizolam doesn't affect serotonin afaik.
Etizolam is very similar to benzos, and tramadol is very similar to opioids.
It's just like combining any depressants.
As long as you choose a proper dose, you'll be fine.
 
This quote from wikipedia has me worried.

"In EEG tests of healthy volunteers, etizolam showed some characteristics of tricyclic antidepressants"

And a poster on another forum said:

"Etizolam is also claimed to increase intra-synaptic concentrations of both serotonin (5-HT) and norepinephrine (NE) through dual blockade of neuronal reuptake of these neurotransmitters"

This is the reason for my concern, I don't want to run the risk of getting serotonin syndrome.
 
I call bullshit on that statement, they also said etiz has reverse tolerance but any etiz user will tell you that's bullshit as well. First off let me say that this is my go-to combo for withdrawal and if anything the etiz smooths out the SSRI effects while acting as an anticonvulsant, never noticed any problems whatsoever. I made a similar thread here [ http://www.bluelight.org/vb/threads...-REALLY-have-tricyclic-antidepressant-effects], I had the same worries as you but now I feel I have enough experience to call BS. I've taken etiz after HEAVY serotonergics, some with MAOI properties and have had no problems (aMT, MDMA, MDA, MXE, 5/6-APB etc...), it always acted like any other benzo and would bring my HR back to normal and bting me back to earth. If it really had these type of effects I would've run into some trouble by now. I'm not able to provide the satisfying scientific reasons how that claim was even brought to light but I can say that you won't run into any serious problems when combining etiz with drugs that act on 5-ht.
 
Thank you brother, That is exactly what I wanted to hear.

And your thread that you created contains all the information that I needed. I'd wish I found it earlier this morning and I would have started staggering my tramadol doses after my breakfast, lol. I'm really looking forward to seeing this combination's synergy. I have always enjoyed both drugs very much and think today should be very enjoyable. I'd like to thank you once again and hope you have a wonderful day.

Take it easy :)
 
Let's assume that etizolam has SNRI properties. Tramadol is an SNRI too. SNRIs alone CANNOT cause serotonin syndrome. You don't have to worry about SS.
 
^ Also true, SS is almost always caused by mixing some sort of MAOI with an SSRI or monoamine releaser. I know someone who is irresponsibly prescribed focalin, an SSRI, and tramadol and hasn't had any problems as well as another friend who is on two SSRI's.
 
I popped just to say that I'm more than sure articles on wikipedia are edited by vendors selling "research chemicals" to present their products more appealing. This doesn't have to be the case here as I myself see no profits in having a benzodiazepine acting as 5-HT reuptake inhibitor, but let's keep in mind most vendors are just businessmen with little to no knowledge about pharmacology (there are numbers of chemicals released, because their structure just looks nice or they act at some sites popular drugs do). Plain inhibition of serotonin transporter and/or noradrenaline transporter doesn't have much potential to produce pleasurable feeling, most recreationally used SRIs/NRIs/SNRIs have additional properties that are responsible for those compounds being pleasurable (and possibly addictive).
 
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Actually most of these claims come from pubmed studies, if anything labeling your pseudo benzo as an SSRI or SNRI will do to opposite of attract customers as alot of the UK etiz users take them for coming down off empathogen/stim binges which would in theory only cause more room for complications. I think these claims have no backbone, the "Etizolam is also claimed" supports the idea that this is only a mere assumption. How this assumption was made I don't know.
 
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