Lysergamides Ergot pinning and mycelium

[red22]

Germinated sclerotium of Claviceps purpurea with ascomata.
Bailey, K. L., Gossen, B. D., Gugel, R. K., Morrall, R. A. A. Diseases of field crops in Canada. 2003. Canadian Phytopathological Society. ISBN 9780969162766. phytopath.ca/publications/5479-2


Microphotos:


Ergot fruiting bodies. Coloured scanning electron micrograph (SEM) of the fruiting bodies of the fungus ergot (Claviceps purpurea). Fruiting bodies are the sexual reproductive structure of fungi. This fungus infects cereal crops and grasses, causing a reduced yield. During infection ergot induces the plants' cells to divide and enlarge, resulting in a large mass (black), called the sclerotium, which allows the fungus to survive adverse conditions. Ingestion of ergot causes poisoning (ergotism) in animals and humans, which can be fatal. Symptoms can include vomiting, gangrene and hallucinations. A number of medical drugs, as well as LSD, are derived from ergot.
Eye of Science / Science Photo Library
sciencephoto.com/media/14094/view/ergot-fungus-sem
sciencephoto.com/media/14092/view/ergot-fungus-sem

 

[daturetard]

Damn they look like baby PEs kinda

 

[Esperighanto]

Working with this shit is so dangerous that lysergamide chemistry (specifically when LA needs to be acquired and not just purchased as a conveniently close ester) has recently become slightly more economical to synthesize from scratch compared to cultivating ergot. There's a non-trivial but not-too-crazy six step synth that just came out of Japan that would allow for super novel variants of LA that has me excited to see what sorts of novel lysergamides arise from it, I saw 14-chloro-LA come out of the initial paper which is pretty neat.

 

[red22]

Post the info.

 

[Esperighanto]

Post the info.

Here's a link to the DOI so you can sci-hub it, "Six-Step Synthesis of (±)-Lysergic Acid".