Enantiomer Studies Coming

[indigoaura]

I found this very interesting:

MDMA Drug Developers Reprioritize Following Lykos Rejection in PTSD

After the FDA declined to approve Lykos Therapeutics’ MDMA-assisted therapy for post-traumatic stress disorder, companies are pivoting away from or delaying similar therapeutics targeting the psychiatric disease.

www.biospace.com

Meanwhile, with EMP-01, atai is hoping to improve the safety of MDMA by focusing on one of its two enantiomers.

MDMA is an equal mixture of both (S)-MDMA and (R)-MDMA. The (S) enantiomer is very much like a stimulant, Rao explained, with so-called entactogenic properties that induce the external, social effects of MDMA. (R)-MDMA, on the other hand, has more exergonic activity thought to contribute to the psychedelic effects, he said. With the stimulant effects of the (S) enantiomer posing potential cardiovascular risks for PTSD patients, atai used only (R)-MDMA in its candidate to potentially improve the therapeutic index of traditional MDMA.

“What we found is that the compound was very different than anticipated, and in a good way,” Rao said. In a traditional MDMA trial, a common dose would be 150 mg, which would include 75 mg of (R)-MDMA and 75 mg of (S)-MDMA. Atai’s molecule comprises 225 mg of (R)-MDMA. In a Phase I trial, it elicited psychedelic effects beyond hallucination, enabling introspection and affecting patients’ ability to see their lives differently, Rao said. EMP-01 was found to be well-tolerated in healthy volunteers.

I wonder if this may mean we will see the enantiomers of MDMA become more readily available as conversations surrounding differing effects profiles further develop.

 

[G_Chem]

Interesting that they used 150mg racemic too.. I’m wondering if that’s more commonly used in studies these days then the old 100-125mg?

-GC

 

[Didgital]

I wonder if this may mean we will see the enantiomers of MDMA become more readily available as conversations surrounding differing effects profiles further develop.

Maybe...

I have seen S-MDA, but only from very private circles and always small amounts.

 

[A9254DF]

In actually messing around with this at the moment - resolving a racemic mix into the r enantiomer.
It’d an interesting area of study with most psychedelic with chiral centre’s actually. I’d be interested in splitting the enantiomers of MDA, TMA and a couple others.